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DC Field | Value | Language |
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dc.citation.endPage | 209 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 197 | - |
dc.citation.title | CANCER LETTERS | - |
dc.citation.volume | 324 | - |
dc.contributor.author | Yoon, Mi Jin | - |
dc.contributor.author | Kim, Eun Hee | - |
dc.contributor.author | Kwon, Taeg Kyu | - |
dc.contributor.author | Park, Sun Ah | - |
dc.contributor.author | Choi, Kyeong Sook | - |
dc.date.accessioned | 2023-12-22T04:37:39Z | - |
dc.date.available | 2023-12-22T04:37:39Z | - |
dc.date.created | 2016-08-02 | - |
dc.date.issued | 2012-11 | - |
dc.description.abstract | In this study, we investigated the role of Ca2+ in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondria! Ca2+ overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na+/Ca2+ exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca2+ overload and effectively induce paraptosis in malignant breast cancer cells. (C) 2012 Elsevier Ireland Ltd. All rights reserved | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, v.324, no.2, pp.197 - 209 | - |
dc.identifier.doi | 10.1016/j.canlet.2012.05.018 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.scopusid | 2-s2.0-84864390522 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/20172 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304383512003126 | - |
dc.identifier.wosid | 000307797000010 | - |
dc.language | 영어 | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Paraptosis | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | Mitochondrial Ca2+ | - |
dc.subject.keywordAuthor | Proteasomal inhibition | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRESS | - |
dc.subject.keywordPlus | CURCUMIN INDUCES APOPTOSIS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | MITOTIC CATASTROPHE | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | ACTIVATION | - |
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