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- Suh, Pann-Ghill
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Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase
- Author(s)
- Chang, Young-Tae, Choi, Gildon, Bae, Yoe-Sik, Burdett, Matthew, Moon, Ho-Sang, Lee, Jae Wook, Gray, Nathanael S., Schultz, Peter G., Meijer, Laurent, Chung, Sung-Kee, Choi, Kwan Yong, Suh, Pann-Ghill, Ryu, Sung Ho
- Issued Date
- 2002-09
- Citation
- CHEMBIOCHEM, v.3, no.9, pp.897 - +
- Abstract
- Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 muM). This new IP3K inhibitor 1 increased Ca2+ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C
- Publisher
- WILEY-V C H VERLAG GMBH
- ISSN
- 1439-4227
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