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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

Cited 33 times inthomson ciCited 31 times inthomson ci
Title
Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase
Author
Chang, Young-TaeChoi, GildonBae, Yoe-SikBurdett, MatthewMoon, Ho-SangLee, Jae WookGray, Nathanael S.Schultz, Peter G.Meijer, LaurentChung, Sung-KeeChoi, Kwan YongSuh, Pann-GhillRyu, Sung Ho
Issue Date
2002-09
Publisher
WILEY-V C H VERLAG GMBH
Citation
CHEMBIOCHEM, v.3, no.9, pp.897 - +
Abstract
Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 muM). This new IP3K inhibitor 1 increased Ca2+ ion release as a result of IP3 accumulation in HL60 cells but did not affect any other metabolic enzymes, such as inositol 1,4,5-trisphosphate 5-phosphatase or phospholipase C
URI
https://scholarworks.unist.ac.kr/handle/201301/16445
URL
http://onlinelibrary.wiley.com/doi/10.1002/1439-7633(20020902)3:9%3C897::AID-CBIC897%3E3.0.CO;2-B/abstract
DOI
10.1002/1439-7633(20020902)3:9<897::AID-CBIC897>3.0.CO;2-B
ISSN
1439-4227
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BIO_Journal Papers
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