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박성호
Park, Sung Ho

박성호

생명과학과

  • Laboratory of Molecular Immunology
Research Interests
Cytokine Imprints;Plasticity in Macrophages;Innate Immune Memory;Autoimmune Diseases;Leukemia;Bioinfomatics;사이토카인;생물정보학;백혈병;면역
Lab Description
We study the immunologic aspects of a very broad range of human diseases, encompassing investigations in the fields of autoimmune diseases, inflammatory diseases, and hematopoiesis such as rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis and leukemia. We are interested in how cytokines and inflammatory factors regulate the activation and function of innate immune and stromal cells, with a focus on macrophages, monocytes and fibroblasts. We are currently studying how cytokines such as IFNs, TNF and IL1 reprogram macrophage responses to the environment by altering transcription factor networks, chromatin states, cell metabolism, and the epigenomic landscape of enhancers. Such reprogramming results in macrophages that are hyper-responsive (primed) or desensitized (tolerized) to inflammatory challenges. To understand of underlying mechanisms, we integrate basic science investigation of signaling and epigenetic mechanisms with translational research using disease models and analysis of human disease samples with genome wide approaches such as single cell RNA-seq, ChIP-seq, and ATAC-seq. We are incorporating a precision medicine approach to identify disease mechanisms and the best therapies for individual patients. Our long-term research goals are to identify signaling and epigenetic mechanisms that can be targeted by new therapies for inflammatory diseases, including biological approaches to enhancing clinical outcomes.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
PTP4A1 alleviates angiotensin II-induced aortic aneurysmal lesions by regulating immature mural neovascularisation File

Cho, Min Ji , Hwang, Byungtae , Lee, Joo Chan , Seo, Young Hoon , Park, Hye Rang , Lee, Jangwook , Lee, Nam-Kyung , Yang, Wonjun , Kang, Mi-Jung , Kim, Yeon-Gu , et al

Article Issue Date2025-11 View28
Piezo1-mediated mechanotransduction regulates the translational activity, function and lung pathogenicity of group 2 innate lymphoid cells File File

Lim, MinYeong , Park, Seonjun , Joo, Yoon Ha , Kim, Sung Eun , Ham, Min Hee , Kim, TaeSoo , Kwak, Kihyuck , Kim, Sung Joon , Lee, Jung Chan , Park, Sung Ho , et al

Article Issue Date2025-08 View49
CD7-Targeted Cytotoxic Potency of Diphtheria Toxin- and Ricin-Based Immunotoxins in Targeted Therapy for T-Cell Acute Lymphoblastic Leukemia File

Lee, Hyun Bin , Park, Seong Guk , Kim, Hyo Jeong , Jeon, Jun Pyo , Oh, SuHyeon , Lee, SangJoon , Park, Sung Ho , Kang, Sebyung

Article Issue Date2025-06 View178
Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease File File

Yoon Jae-Won , Kim Kyung Min , Cho Sookyung , Cho Min-Ji , Park Seonjun , Hwang Daehee , Kim Hye Ryun , Park, Sung Ho , Cho Jae-Ho , Jeong Hyobin , et al

Article Issue Date2025-02 View35
CD13-targeting and TRAIL-displaying protein nanoparticles effectively induce apoptotic cell death of acute myeloid leukemia, prolonging survival in mouse models File

Jun, Heejin , Yeo, Mirae , Jeon, Jun Pyo , Eom, Soomin , Kim, Hyo Jeong , Kim, Yunjung , Jang, Eunjung , Park, Sung Ho , Kim, Eunhee , Kang, Sebyung

Article Issue Date2024-12 View294
Longitudinal multiomic profiling and corticosteroid modulation of the immediate innate immune response to an adenovirus-vector vaccine File

Choi, Seong Jin , Lee, Wonhyo , Kim, Sang Cheol , Jo, Hye-Yeong , Park, Hyun-Young , Bin Kim, Hong , Park, Woong-Yang , Park, Sung Ho , Ko, Jae-Hoon , Lee, Jeong Seok

Article Issue Date2024-11 View128
NRF2 is a spatiotemporal metabolic hub essential for the polyfunctionality of Th2 cells File

Choi, Garam , Ju, Hye-Yeon , Bok, Jahyun , Choi, Jungseo , Shin, Jae Woo , Oh, Hansol , Jeon, Yeojin , Kim, Jiyeon , Kim, Daehong , Moon, Heesu , et al

Article Issue Date2024-07 View107
Protein cage nanoparticle-based NK cell-engaging nanodrones (NKeNDs) effectively recruit NK cells to target tumor sites and suppress tumor growth File

Park, Seong Guk , Kim, Hyo Jeong , Lee, Hyun Bin , Eom, Soomin , Jun, Heejin , Jang, Yeongim , Park, Sung Ho , Kang, Sebyung

Article Issue Date2024-02 View155
High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity File

Oh, Jiyoung , Park, Chanho , Kim, Sahee , Kim, Min , Kim, Chu-Sook , Jo, Woobeen , Park, Sung Ho , Yi, Gwan-Su , Park, Jiyoung

Article Issue Date2023-08 View150
Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways File File

Yoo, Eun Jin , Oh, Kook-Hwan , Piao, Honglin , Kang, Hyun Je , Jeong, Gyu Won , Park, Hyun , Lee, Chang Jun , Ryu, Hyunjin , Yang, Seung Hee , Kim, Myung-Gyu , et al

Article Issue Date2023-07 View182
Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth File File

Choi, Hyukjun , Yeo, Mirae , Kang, Yujin , Kim, Hyo Jeong , Park, Seong Guk , Jang, Eunjung , Park, Sung Ho , Kim, Eunhee , Kang, Sebyung

Article Issue Date2023-01 View198
RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts File

Bae, Seyeon , Kim, Kibyeong , Kang, Keunsoo , Kim, Haemin , Lee, Minjoon , Oh, Brian , Kaneko, Kaichi , Ma, Sungkook , Choi, Jae Hoon , Kwak, Hojoong , et al

Article Issue Date2023-01 View141
2 '-5 ' oligoadenylate synthetase-like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability File File

Kim, Tae Kyeong , Jeon, Sejin , Park, Seonjun , Sonn, Seong-Keun , Seo, Seungwoon , Suh, Joowon , Jin, Jing , Kweon, Hyae Yon , Kim, Sinai , Moon, Shin Hye , et al

Article Issue Date2022-11 View196
The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke File

Kim, Sinai , Lee, Wonhyo , Jo, Huiju , Sonn, Seong-Keun , Jeong, Se-Jin , Seo, Seungwoon , Suh, Joowon , Jin, Jing , Kweon, Hyae Yon , Kim, Tae Kyeong , et al

Article Issue Date2022-08 View127
Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression File File

Byun, Seongjun , Lee, Chan Hyeong , Jeong, Hyumgmin , Kim, Hyejin , Kwon, Hyug Moo , Park, Sung Ho , Myung, Kyungjae , An, Jungeun , Ko, Myunggon

Article Issue Date2022-06 View177
Pharmacological Rescue with SR8278, a Circadian Nuclear Receptor REV-ERBα Antagonist as a Therapy for Mood Disorders in Parkinson’s Disease File File

Kim, Jeongah , Park, Inah , Jang, Sangwon , Choi, Mijung , Kim, Doyeon , Sun, Woong , Choe, Youngshik , Choi, Ji-Woong , Moon, Cheil , Park, Sung Ho , et al

Article Issue Date2022-03 View155
Comparison of 3-month cytogenetic and molecular assays for early assessment of long-term clinical impact after BCR-ABL1 tyrosine kinase inhibitor treatment in chronic myeloid leukemia File

Kee, Kyung-Mi , Kim, Soo-Hyun , Yang, Seon-Young , Shin, Jeong-U , Nam, Yoon-Won , Jang, Eun-Jung , Kim, Hongtae , Lee, Semin , Park, Sung Ho , Kim, Dong-Wook

Article Issue Date2022-01 View164
B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction File File

Oh, Younseo , Park, Robin , Kim, So Yeon , Park, Sung-ho , Jo, Sungsin , Kim, Tae-Hwan , Ji, Jong Dae

Article Issue Date2021-10 View160
Regulation of Macrophage Activation and Differentiation in Atherosclerosis File File

Park, Sung Ho

Article Issue Date2021-09 View96
Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets File File

Lee, Jeong Seok , Koh, June-Young , Yi, Kijong , Kim, Young-Il , Park, Su-Jin , Kim, Eun-Ha , Kim, Se-Mi , Park, Sung Ho , Ju, Young Seok , Choi, Young Ki , et al

Article Issue Date2021-07 View156
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