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박성호
Park, Sung Ho

박성호

Department of Biological Sciences(생명과학과)

  • Laboratory of Molecular Immunology
Research Interests
Cytokine Imprints;Plasticity in Macrophages;Innate Immune Memory;Autoimmune Diseases;Leukemia;Bioinfomatics;사이토카인;생물정보학;백혈병;면역
Lab Description
We study the immunologic aspects of a very broad range of human diseases, encompassing investigations in the fields of autoimmune diseases, inflammatory diseases, and hematopoiesis such as rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis and leukemia. We are interested in how cytokines and inflammatory factors regulate the activation and function of innate immune and stromal cells, with a focus on macrophages, monocytes and fibroblasts. We are currently studying how cytokines such as IFNs, TNF and IL1 reprogram macrophage responses to the environment by altering transcription factor networks, chromatin states, cell metabolism, and the epigenomic landscape of enhancers. Such reprogramming results in macrophages that are hyper-responsive (primed) or desensitized (tolerized) to inflammatory challenges. To understand of underlying mechanisms, we integrate basic science investigation of signaling and epigenetic mechanisms with translational research using disease models and analysis of human disease samples with genome wide approaches such as single cell RNA-seq, ChIP-seq, and ATAC-seq. We are incorporating a precision medicine approach to identify disease mechanisms and the best therapies for individual patients. Our long-term research goals are to identify signaling and epigenetic mechanisms that can be targeted by new therapies for inflammatory diseases, including biological approaches to enhancing clinical outcomes.
Researcher ID Research Gate ORCiD Scopus Google Scholar
Previous
Protein cage nanoparticle-based NK cell-engaging nanodrones (NKeNDs) effectively recruit NK cells to target tumor sites and suppress tumor growth File

Park, Seong Guk , Kim, Hyo Jeong , Lee, Hyun Bin , Eom, Soomin , Jun, Heejin , Jang, Yeongim , Park, Sung Ho , Kang, Sebyung

Article Issue Date2024-02 View10
High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity File

Oh, Jiyoung , Park, Chanho , Kim, Sahee , Kim, Min , Kim, Chu-Sook , Jo, Woobeen , Park, Sung Ho , Yi, Gwan-Su , Park, Jiyoung

Article Issue Date2023-08 View14
Macrophage transcription factor TonEBP promotes systemic lupus erythematosus and kidney injury via damage-induced signaling pathways File File

Yoo, Eun Jin , Oh, Kook-Hwan , Piao, Honglin , Kang, Hyun Je , Jeong, Gyu Won , Park, Hyun , Lee, Chang Jun , Ryu, Hyunjin , Yang, Seung Hee , Kim, Myung-Gyu , et al

Article Issue Date2023-07 View16
RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts File

Bae, Seyeon , Kim, Kibyeong , Kang, Keunsoo , Kim, Haemin , Lee, Minjoon , Oh, Brian , Kaneko, Kaichi , Ma, Sungkook , Choi, Jae Hoon , Kwak, Hojoong , et al

Article Issue Date2023-01 View10
Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth File File

Choi, Hyukjun , Yeo, Mirae , Kang, Yujin , Kim, Hyo Jeong , Park, Seong Guk , Jang, Eunjung , Park, Sung Ho , Kim, Eunhee , Kang, Sebyung

Article Issue Date2023-01 View7
2 '-5 ' oligoadenylate synthetase-like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability File File

Kim, Tae Kyeong , Jeon, Sejin , Park, Seonjun , Sonn, Seong-Keun , Seo, Seungwoon , Suh, Joowon , Jin, Jing , Kweon, Hyae Yon , Kim, Sinai , Moon, Shin Hye , et al

Article Issue Date2022-11 View9
The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke File

Kim, Sinai , Lee, Wonhyo , Jo, Huiju , Sonn, Seong-Keun , Jeong, Se-Jin , Seo, Seungwoon , Suh, Joowon , Jin, Jing , Kweon, Hyae Yon , Kim, Tae Kyeong , et al

Article Issue Date2022-08 View15
Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression File File

Byun, Seongjun , Lee, Chan Hyeong , Jeong, Hyumgmin , Kim, Hyejin , Kwon, Hyug Moo , Park, Sung Ho , Myung, Kyungjae , An, Jungeun , Ko, Myunggon

Article Issue Date2022-06 View10
Pharmacological Rescue with SR8278, a Circadian Nuclear Receptor REV-ERBα Antagonist as a Therapy for Mood Disorders in Parkinson’s Disease File File

Kim, Jeongah , Park, Inah , Jang, Sangwon , Choi, Mijung , Kim, Doyeon , Sun, Woong , Choe, Youngshik , Choi, Ji-Woong , Moon, Cheil , Park, Sung Ho , et al

Article Issue Date2022-03 View13
Comparison of 3-month cytogenetic and molecular assays for early assessment of long-term clinical impact after BCR-ABL1 tyrosine kinase inhibitor treatment in chronic myeloid leukemia File

Kee, Kyung-Mi , Kim, Soo-Hyun , Yang, Seon-Young , Shin, Jeong-U , Nam, Yoon-Won , Jang, Eun-Jung , Kim, Hongtae , Lee, Semin , Park, Sung Ho , Kim, Dong-Wook

Article Issue Date2022-01 View12
B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction File File

Oh, Younseo , Park, Robin , Kim, So Yeon , Park, Sung-ho , Jo, Sungsin , Kim, Tae-Hwan , Ji, Jong Dae

Article Issue Date2021-10 View6
Regulation of Macrophage Activation and Differentiation in Atherosclerosis File File

Park, Sung Ho

Article Issue Date2021-09 View17
Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets File File

Lee, Jeong Seok , Koh, June-Young , Yi, Kijong , Kim, Young-Il , Park, Su-Jin , Kim, Eun-Ha , Kim, Se-Mi , Park, Sung Ho , Ju, Young Seok , Choi, Young Ki , et al

Article Issue Date2021-07 View13
An Impaired Inflammatory and Innate Immune Response in COVID-19 File

Park, Sung Ho

Article Issue Date2021-06 View7
Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis File

Jeon, Sejin , Kim, Tae Kyeong , Jeong, Se-Jin , Jung, In-Hyuk , Kim, Nayoung , Lee, Mi-Ni , Sonn, Seong-Keun , Seo, Seungwoon , Jin, Jing , Kweon, Hyae Yon , et al

Article Issue Date2020-11 View10
Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19 File File

Lee, Jeong Seok , Park, Seongwan , Jeong, Hye Won , Ahn, Jin Young , Choi, Seong Jin , Lee, Hoyoung , Choi, Baekgyu , Nam, Su Kyung , Sa, Moa , Kwon, Ji-Soo , et al

Article Issue Date2020-07 View12
VEGF-A drives TOX-dependent T cell exhaustion in anti-PD-1-resistant microsatellite stable colorectal cancers File

Kim, Chang Gon , Jang, Mi , Kim, Youngun , Leem, Galam , Kim, Kyung Hwan , Lee, Hoyoung , Kim, Tae-Shin , Choi, Seong Jin , Kim, Hyung-Don , Han, Ji Won , et al

Article Issue Date2019-11 View8
TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis File

Roh, Christopher , Park, Sung Ho , Lee, Angela , Yuan, Ruoxi , Ivashkiv, Lionel B , Kalliolias, George D

Article Issue Date2019-09 View5
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair File

Kusnadi, Anthony , Park, Sung Ho , Yuan, Ruoxi , Pannellini, Tania , Giannopoulou, Eugenia , Oliver, David , Lu, Theresa , Park-Min, Kyung-Hyun , Ivashkiv, Lionel B.

Article Issue Date2019-08 View8
IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation File

Kang, Kyuho , Bachu, Mahesh , Park, Sung Ho , Kang, Keunsoo , Bae, Seyeon , Park-Min, Kyung-Hyun , Ivashkiv, Lionel B.

Article Issue Date2019-07 View9
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