사진

Park, Sung Ho (박성호)

Department
Department of Biological Sciences(생명과학과)
Website
http://immunology.unist.ac.kr/
Lab
Laboratory of Molecular Immunology (분자면역학 연구실)
Research Keywords
사이토카인, 생물정보학, 백혈병, 면역, Cytokine Imprints, Plasticity in Macrophages, Innate Immune Memory, Autoimmune Diseases, Leukemia, Bioinfomatics
Research Interests
We study the immunologic aspects of a very broad range of human diseases, encompassing investigations in the fields of autoimmune diseases, inflammatory diseases, and hematopoiesis such as rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis and leukemia. We are interested in how cytokines and inflammatory factors regulate the activation and function of innate immune and stromal cells, with a focus on macrophages, monocytes and fibroblasts. We are currently studying how cytokines such as IFNs, TNF and IL1 reprogram macrophage responses to the environment by altering transcription factor networks, chromatin states, cell metabolism, and the epigenomic landscape of enhancers. Such reprogramming results in macrophages that are hyper-responsive (primed) or desensitized (tolerized) to inflammatory challenges. To understand of underlying mechanisms, we integrate basic science investigation of signaling and epigenetic mechanisms with translational research using disease models and analysis of human disease samples with genome wide approaches such as single cell RNA-seq, ChIP-seq, and ATAC-seq. We are incorporating a precision medicine approach to identify disease mechanisms and the best therapies for individual patients. Our long-term research goals are to identify signaling and epigenetic mechanisms that can be targeted by new therapies for inflammatory diseases, including biological approaches to enhancing clinical outcomes.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2022-01Comparison of 3-month cytogenetic and molecular assays for early assessment of long-term clinical impact after BCR-ABL1 tyrosine kinase inhibitor treatment in chronic myeloid leukemiaKee, Kyung-Mi; Kim, Soo-Hyun; Yang, Seon-Young, et alARTICLE7 Comparison of 3-month cytogenetic and molecular assays for early assessment of long-term clinical impact after BCR-ABL1 tyrosine kinase inhibitor treatment in chronic myeloid leukemia
2021-10B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO inductionOh, Younseo; Park, Robin; Kim, So Yeon, et alARTICLE81 B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction
2021-09Regulation of Macrophage Activation and Differentiation in AtherosclerosisPark, Sung HoARTICLE56 Regulation of Macrophage Activation and Differentiation in Atherosclerosis
2021-07Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferretsLee, Jeong Seok; Koh, June-Young; Yi, Kijong, et alARTICLE121 Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets
2021-06An Impaired Inflammatory and Innate Immune Response in COVID-19Park, Sung HoARTICLE51 An Impaired Inflammatory and Innate Immune Response in COVID-19
2020-11Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate AtherosclerosisJeon, Sejin; Kim, Tae Kyeong; Jeong, Se-Jin, et alARTICLE161 Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis
2020-07Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19Lee, Jeong Seok; Park, Seongwan; Jeong, Hye Won, et alARTICLE436 Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
2019-11VEGF-A drives TOX-dependent T cell exhaustion in anti-PD-1-resistant microsatellite stable colorectal cancersKim, Chang Gon; Jang, Mi; Kim, Youngun, et alARTICLE382 VEGF-A drives TOX-dependent T cell exhaustion in anti-PD-1-resistant microsatellite stable colorectal cancers
2019-09TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysisRoh, Christopher; Park, Sung Ho; Lee, Angela, et alARTICLE349 TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis
2019-08The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue RepairKusnadi, Anthony; Park, Sung Ho; Yuan, Ruoxi, et alARTICLE303 The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
2019-07IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activationKang, Kyuho; Bachu, Mahesh; Park, Sung Ho, et alARTICLE254 IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
2019-06Insights into rheumatic diseases from next-generation sequencingDonlin, Laura T.; Park, Sung Ho; Giannopoulou, Eugenia, et alARTICLE280 Insights into rheumatic diseases from next-generation sequencing
2018-04Regulation of age-associated B cells by IRF5 in systemic autoimmunityManni, Michela; Gupta, Sanjay; Ricker, Edd, et alARTICLE345 Regulation of age-associated B cells by IRF5 in systemic autoimmunity
2018-02Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse modelsSokhi, Upneet K.; Liber, Mark P.; Frye, Laura, et alARTICLE325 Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
2017-10Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activationPark, Sung Ho; Kang, Kyuho; Giannopoulou, Eugenia, et alARTICLE326 Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
2017-08Interferon-gamma Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAFKang, Kyuho; Park, Sung Ho; Chen, Janice, et alARTICLE304 Interferon-gamma Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF
2017-07Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytesLoupasakis, Konstantinos; Kuo, David; Sokhi, Upneet K., et alARTICLE306 Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes
2016-08Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophagesHuynh, Linda; Kusnadi, Anthony; Park, Sung Ho, et alARTICLE391 Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages
2014-11Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulationPark-Min, Kyung-Hyun; Lim, Elisha; Lee, Min Joon, et alARTICLE329 Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation
2013-09Synergistic Activation of Inflammatory Cytokine Genes by Interferon-gamma-Induced Chromatin Remodeling and Toll-like Receptor SignalingQiao, Yu; Giannopoulou, Eugenia G.; Chan, Chun Hin, et alARTICLE296 Synergistic Activation of Inflammatory Cytokine Genes by Interferon-gamma-Induced Chromatin Remodeling and Toll-like Receptor Signaling

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