사진

Park, Sung Ho (박성호)

Department
Department of Biological Sciences(생명과학과)
Website
http://immunology.unist.ac.kr/
Lab
Laboratory of Molecular Immunology (분자면역학 연구실)
Research Keywords
사이토카인, 생물정보학, 백혈병, 면역, Cytokine Imprints, Plasticity in Macrophages, Innate Immune Memory, Autoimmune Diseases, Leukemia, Bioinfomatics
Research Interests
We study the immunologic aspects of a very broad range of human diseases, encompassing investigations in the fields of autoimmune diseases, inflammatory diseases, and hematopoiesis such as rheumatoid arthritis, systemic lupus erythematosus, atherosclerosis and leukemia. We are interested in how cytokines and inflammatory factors regulate the activation and function of innate immune and stromal cells, with a focus on macrophages, monocytes and fibroblasts. We are currently studying how cytokines such as IFNs, TNF and IL1 reprogram macrophage responses to the environment by altering transcription factor networks, chromatin states, cell metabolism, and the epigenomic landscape of enhancers. Such reprogramming results in macrophages that are hyper-responsive (primed) or desensitized (tolerized) to inflammatory challenges. To understand of underlying mechanisms, we integrate basic science investigation of signaling and epigenetic mechanisms with translational research using disease models and analysis of human disease samples with genome wide approaches such as single cell RNA-seq, ChIP-seq, and ATAC-seq. We are incorporating a precision medicine approach to identify disease mechanisms and the best therapies for individual patients. Our long-term research goals are to identify signaling and epigenetic mechanisms that can be targeted by new therapies for inflammatory diseases, including biological approaches to enhancing clinical outcomes.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2020-07Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19Lee, Jeong Seok; Park, Seongwan; Jeong, Hye Won, et alARTICLE168 Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
2019-11VEGF-A drives TOX-dependent T cell exhaustion in anti-PD-1-resistant microsatellite stable colorectal cancersKim, Chang Gon; Jang, Mi; Kim, Youngun, et alARTICLE158 VEGF-A drives TOX-dependent T cell exhaustion in anti-PD-1-resistant microsatellite stable colorectal cancers
2019-09TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysisRoh, Christopher; Park, Sung Ho; Lee, Angela, et alARTICLE137 TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis
2019-08The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue RepairKusnadi, Anthony; Park, Sung Ho; Yuan, Ruoxi, et alARTICLE156 The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
2019-07IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activationKang, Kyuho; Bachu, Mahesh; Park, Sung Ho, et alARTICLE144 IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
2019-06Insights into rheumatic diseases from next-generation sequencingDonlin, Laura T.; Park, Sung Ho; Giannopoulou, Eugenia, et alARTICLE156 Insights into rheumatic diseases from next-generation sequencing
2018-04Regulation of age-associated B cells by IRF5 in systemic autoimmunityManni, Michela; Gupta, Sanjay; Ricker, Edd, et alARTICLE233 Regulation of age-associated B cells by IRF5 in systemic autoimmunity
2018-02Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse modelsSokhi, Upneet K.; Liber, Mark P.; Frye, Laura, et alARTICLE211 Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models
2017-10Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activationPark, Sung Ho; Kang, Kyuho; Giannopoulou, Eugenia, et alARTICLE213 Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
2017-08Interferon-gamma Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAFKang, Kyuho; Park, Sung Ho; Chen, Janice, et alARTICLE194 Interferon-gamma Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF
2017-07Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytesLoupasakis, Konstantinos; Kuo, David; Sokhi, Upneet K., et alARTICLE202 Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes
2016-08Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophagesHuynh, Linda; Kusnadi, Anthony; Park, Sung Ho, et alARTICLE207 Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages
2014-11Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulationPark-Min, Kyung-Hyun; Lim, Elisha; Lee, Min Joon, et alARTICLE229 Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation
2013-09Synergistic Activation of Inflammatory Cytokine Genes by Interferon-gamma-Induced Chromatin Remodeling and Toll-like Receptor SignalingQiao, Yu; Giannopoulou, Eugenia G.; Chan, Chun Hin, et alARTICLE180 Synergistic Activation of Inflammatory Cytokine Genes by Interferon-gamma-Induced Chromatin Remodeling and Toll-like Receptor Signaling
2013-04Tumor Necrosis Factor Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial FibroblastsLee, Angela; Qiao, Yu; Grigoriev, Galina, et alARTICLE241 Tumor Necrosis Factor Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts
2013-04Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulationChoe, Han Kyoung; Kim, Hee-Dae; Park, Sung Ho, et alARTICLE218 Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation
2011-07Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophagesPark, Sung Ho; Park-Min, Kyung-Hyun; Chen, Janice, et alARTICLE222 Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages
2010-11Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibodyCheong, Cheolho; Choi, Jae-Hoon; Vitale, Laura, et alARTICLE690 Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody
2008-02Generation and application of new rat monoclonal antibodies against synthetic FLAG and OLLAS tags for improved immunodetectionPark, Sung Ho; Cheong, Cheolho; Idoyaga, Juliana, et alARTICLE714 Generation and application of new rat monoclonal antibodies against synthetic FLAG and OLLAS tags for improved immunodetection
2008-01Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cellsDo, Yoonkyung; Park, Chae Gyu; Kang, Young-Sun, et alARTICLE701 Broad T cell immunity to the LcrV virulence protein is induced by targeted delivery to DEC-205/CD205-positive mouse dendritic cells

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