사진

Kim, Hongtae (김홍태)

Department
Department of Biological Sciences(생명과학과)
Website
https://faculty.unist.ac.kr/khtlab/
Lab
Cancer/DNA damage Lab. (암/유전자 손상 반응 실험실)
Research Keywords
암, DNA 복구, DNA 손상 반응, 만성골수성백혈병, 백혈병, Cancer, DNA damage response, DDR, CML, Chronic myelogenous leukemia
Research Interests
My lab focuses on studying the DNA damage response pathway and development/progression of chronic myeloid leukemia (CML). DNA damage responses are important in maintaining genetic stability in eukaryotic cells. Because many tumor suppressor proteins including ATM, ATR, MDC1, RNF8, RNF168, RAP80, BRCA1, and BRCA2 are involved in the DNA damage pathway, the complete understanding of this pathway is important in preventing neoplastic transformation. So, our laboratory’s goal is to understand the inherent genetic stability and molecular mechanisms of tumorigenesis by studying DNA damage signaling pathways. CML study is the second project in my Lab. My Lab has focused on identifying genes that are resistant to the tyrosine kinase inhibitor of CML. In addition, we are studying the molecular mechanisms of the discovered genes and applying them to CML patients. The aim of this research project is to ultimately contribute to the treatment and diagnosis of chronic myelogenous leukemia.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2021-01TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolutionKang, Hyun Je; Cheon, Na Young; Park, Hyun, et alARTICLE140 TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution
2019-12GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemiaHan, Seung Hun; Korm, Sovannarith; Han, Ye Gi, et alARTICLE344 GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia
2019-06TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathwaysHan, Ye Gi; Yun, Miyong; Choi, Minji, et alARTICLE195 TRAIP regulates Histone H2B monoubiquitination in DNA damage response pathways
2019-03Hypomorphic Mutations in TONSL Cause SPONASTRIME DysplasiaChang, Hae Ryung; Cho, Sung Yoon; Lee, Jae Hoon, et alARTICLE200 Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia
2019-03INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplificationSohn, Sung-Hwa; Kim, Bohyun; Sul, Hee Jung, et alARTICLE103 INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification
2018-01Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formationLee, Nam Soo; Chang, Hae Ryung; Kim, Soomi, et alARTICLE650 Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation
2017-10RAP80 binds p32 to preserve the functional integrity of mitochondriaChung, Hee Jin; Korm, Sovannarith; Lee, Se-In, et alARTICLE288 RAP80 binds p32 to preserve the functional integrity of mitochondria
2017-07Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemiaHan, SH; Kim, SH; Kim, HJ, et alARTICLE680 Cobll1 is linked to drug resistance and blastic transformation in chronic myeloid leukemia
2016-08Phosphorylation of Astrin Regulates Its Kinetochore FunctionChung, Hee Jin; Park, Ji Eun; Lee, Nam Soo, et alARTICLE293 Phosphorylation of Astrin Regulates Its Kinetochore Function
2016-07Factors forming the BRCA1-A complex orchestrate BRCA1 recruitment to the sites of DNA damageHer, Joonyoung; Lee, Nam Soo; Kim, Yonghwan, et alARTICLE307 Factors forming the BRCA1-A complex orchestrate BRCA1 recruitment to the sites of DNA damage
2016-03RAP80 regulates epithelial-mesenchymal transition related with metastasis and malignancy of cancerPark, Song Yi; Korm, Sovannarith; Chung, Hee Jin, et alARTICLE298 RAP80 regulates epithelial-mesenchymal transition related with metastasis and malignancy of cancer
2016-02SUMOylation regulates nuclear localization and stability of TRAIP/RNF206Park, I. Seul; Han, Ye Gi; Chung, Hee Jin, et alARTICLE298 SUMOylation regulates nuclear localization and stability of TRAIP/RNF206
2016-01TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damageLee, Nam Soo; Chung, Hee Jin; Kim, Hyoung-June, et alARTICLE785 TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage
2016-01Interactome Analysis Reveals that Heterochromatin Protein 1 gamma (HP1 gamma) Is Associated with the DNA Damage Response PathwayKim, Hongtae; Choi, Jae Duk; Kim, Byung-Gyu, et alARTICLE300 Interactome Analysis Reveals that Heterochromatin Protein 1 gamma (HP1 gamma) Is Associated with the DNA Damage Response Pathway
2015-09HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradationKim, Hak-June; Nagano, Yoshito; Choi, Su Jin, et alARTICLE304 HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation
2015-09dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitisLim, Sangho; Kim, Won-Ju; Kim, Yeon-Ho, et alARTICLE276 dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis
2015-08Dimerization of TRAF-interacting protein (TRAIP) regulates the mitotic progressionPark, I. Seul; Jo, Ku-Sung; Won, Hyung-Sik, et alARTICLE296 Dimerization of TRAF-interacting protein (TRAIP) regulates the mitotic progression
2015-07Micelle-templated dendritic gold nanoparticles for enhanced cellular delivery of siRNALee, Min Sang; Kim, Nak Won; Lee, Jung Eun, et alARTICLE256 Micelle-templated dendritic gold nanoparticles for enhanced cellular delivery of siRNA
2015-06In vitro development of canine somatic cell nuclear transfer embryos in different culture mediaKim, Dong-Hoon; No, Jin-Gu; Choi, Mi-Kyung, et alARTICLE226 In vitro development of canine somatic cell nuclear transfer embryos in different culture media
2015-03Pin1 Promotes Neuronal Death in Stroke by Stabilizing Notch Intracellular DomainBaik, Sang-Ha; Fane, Mitchell; Park, Joon Hyung, et alARTICLE318 Pin1 Promotes Neuronal Death in Stroke by Stabilizing Notch Intracellular Domain

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