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Kim, Jae-Ick (김재익)

Department
Department of Biological Sciences(생명과학과)
Lab
Neural Circuit and Neurodegenerative Disease Lab. (신경회로 및 퇴행성뇌질환 연구실)
Research Keywords
파킨슨병, 알츠하이머병, 퇴행성뇌질환, 기저핵 미세회로, 조절성 신경세포, 도파민 신경세포, 신경전달물질 동시전달, 정상 및 병적 노화, Modulatory neurons, Dopamine neurons, Neurotransmitter co-transmission, Normal and pathological ageing, Parkinson's disease, Alzheimer's disease, Neurodegenerative diseases, Basal ganglia microcircuits
Research Interests
Basal ganglia are a group of subcortical nuclei including striatum, globus pallidus, and substantia nigra. The major function of this system is to integrate both sensory and motor information, eventually leading to motor coordination, action selection, and reward-related learning, most of which are severely impaired in Parkinson’s disease. Our long-term goal is to identify the essential modification of basal ganglia circuitry contributing to the development of neurodegenerative diseases. Taking advantage of multi-disciplinary approaches including whole-cell patch clamp, single-unit recording, two-photon laser microscopy, super-resolution imaging, optogenetics, and behavioral assays, we also aim to identify pre-symptomatic physiological markers for Parkinson’s disease.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2020-11O-GlcNAcylation regulates dopamine neuron function, survival, and degeneration in Parkinson diseaseLee, Byeong Eun; Kim, Hye Yun; Kim, Hyun-Jin, et alARTICLE58 O-GlcNAcylation regulates dopamine neuron function, survival, and degeneration in Parkinson disease
2020-09The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammationLee, Hyun-ju; Woo, Hanwoong; Lee, Ha-Eun, et alARTICLE31 The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation
2020-06Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury modelLee, Hyunah; Lee, Hye Yeong; Lee, Byeong Eun, et alARTICLE99 Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model
2020-03Direct-write printing for producing biomimetic patterns with self-aligned neuritesNoh, Sujin; Kim, Kyungha; Kim, Jae-Ick, et alARTICLE217 Direct-write printing for producing biomimetic patterns with self-aligned neurites
2020-03Transient cAMP elevation during systems consolidation enhances remote contextual fear memoryLee, Jaehyun; Lee, Hye-Ryeon; Kim, Jae-Ick, et alARTICLE119 Transient cAMP elevation during systems consolidation enhances remote contextual fear memory
2019-11Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged miceKim, Hye Yun; Yang, Yong Ryoul; Hwang, Hongik, et alARTICLE262 Deletion of PLCγ1 in GABAergic neurons increases seizure susceptibility in aged mice
2018-09The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron SurvivalMaeder, Celine I.; Kim, Jae-Ick; Liang, Xing, et alARTICLE226 The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival
2018-07β-Adrenergic signaling is required for the induction of a labile state during memory reconsolidationLim, Chae-Seok; Kim, Jae-Ick; Kwak, Chuljung, et alARTICLE479 β-Adrenergic signaling is required for the induction of a labile state during memory reconsolidation
2016-12TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal LearningLuo, Sarah X.; Timbang, Leah; Kim, Jae-Ick, et alARTICLE605 TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning
2016-08The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and MemorySim, Su-Eon; Lim, Chae-Seok; Kim, Jae-Ick, et alARTICLE552 The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and Memory
2016-02Impaired learning and memory in CD38 null mutant miceKim, Somi; Kim, TaeHyun; Lee, Hye-Ryeon, et alARTICLE539 Impaired learning and memory in CD38 null mutant mice
2015-10Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neuronsKim, Jae-Ick; Ganesan, Subhashree; Luo, Sarah X., et alARTICLE493 Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons
2015-09Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson's diseaseGuo, Lili; Xiong, Huan; Kim, Jae-Ick, et alARTICLE386 Dynamic rewiring of neural circuits in the motor cortex in mouse models of Parkinson's disease
2015-01Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the StriatumWu, Yu-Wei; Kim, Jae-Ick; Tawfik, Vivianne L., et alARTICLE481 Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum
2013-02Elevated RalA activity in the hippocampus of PI3K gamma knock-out mice lacking NMDAR-dependent long-term depressionSim, Su-Eon; Lee, Hye-Ryeon; Kim, Jae-Ick, et alARTICLE365 Elevated RalA activity in the hippocampus of PI3K gamma knock-out mice lacking NMDAR-dependent long-term depression
2013-01Functional roles of neurotransmitters and neuromodulators in the dorsal striatumDo, Jeehaeh; Kim, Jae-Ick; Bakes, Joseph, et alARTICLE432 Functional roles of neurotransmitters and neuromodulators in the dorsal striatum
2012-06Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor functionWon, Hyejung; Lee, Hye-Ryeon; Gee, Heon Yung, et alARTICLE613 Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
2011-12Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-gamma (PI3Kg)Lee, Bolam; Descalzi, Giannina; Baek, Jinhee, et alARTICLE429 Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-gamma (PI3Kg)
2011-11PI3K gamma is required for NMDA receptor-dependent long-term depression and behavioral flexibilityKim, Jae-Ick; Lee, Hye-Ryeon; Sim, Su-eon, et alARTICLE410 PI3K gamma is required for NMDA receptor-dependent long-term depression and behavioral flexibility
2011-08Impairment of long-term potentiation in the hippocampus of alcohol-treated OLETF ratsMin, Jung-Ah; Lee, Hye-Ryeon; Kim, Jae-Ick, et alARTICLE363 Impairment of long-term potentiation in the hippocampus of alcohol-treated OLETF rats

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