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Lee, Semin (이세민)

Department
Department of Biomedical Engineering(바이오메디컬공학과)
Website
http://compbio.unist.ac.kr
Lab
Computational Biology Lab. (계산생물학 실험실)
Research Keywords
구조생명정보학, 기계학습, 정밀의학, 암유전체학, 단일세포오믹스, Cancer genomics, single-cell omics, structural bioinformatics, machine learning, precision medicine
Research Interests
We analyze a large number of cancer genomes using multiple omics approaches to characterize various kinds of germline/somatic alterations in many different  human cancer types. In order to understand somatic mosaicism, heterogeneity, and evolution in cancer, we also use single-cell genomics approaches.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2021-03An integrated mRNA-microRNA regulatory network identified INHBA and has-miR-135a-5p as predictors of gastric cancer recurrenceSohn, Sung-Hwa; Sul, Hee Jung; Choi, Yeonsong, et alARTICLE29 An integrated mRNA-microRNA regulatory network identified INHBA and has-miR-135a-5p as predictors of gastric cancer recurrence
2021-02Welfare Genome Project: A Participatory Korean Personal Genome Project With Free Health Check-Up and Genetic Report Followed by CounselingJeon, Yeonsu; Jeon, Sungwon; Blazyte, Asta, et alARTICLE37 Welfare Genome Project: A Participatory Korean Personal Genome Project With Free Health Check-Up and Genetic Report Followed by Counseling
2021-02Polygenic risk score validation using Korean genomes of 265 early-onset acute myocardial infarction patients and 636 healthy controlsBhak, Youngjune; Jeon, Yeonsu; Jeon, Sungwon, et alARTICLE14 Polygenic risk score validation using Korean genomes of 265 early-onset acute myocardial infarction patients and 636 healthy controls
2020-12Delineation of the genetic and clinical spectrum, including candidate genes, of monogenic diabetes: a multicenter study in South KoreaCheon, Chong Kun; Lee, Yeoun Joo; Yoo, Sukdong, et alARTICLE50 Delineation of the genetic and clinical spectrum, including candidate genes, of monogenic diabetes: a multicenter study in South Korea
2020-11Treatment strategy for papillary renal cell carcinoma type 2: a case series of seven patients treated based on next generation sequencing dataKim, Ji-Yeon; Jeong, Hyoung-Oh; Heo, Dae Seog, et alARTICLE59 Treatment strategy for papillary renal cell carcinoma type 2: a case series of seven patients treated based on next generation sequencing data
2020-11Prediction of Chronic Periodontitis Severity Using Machine Learning Models Based On Salivary Bacterial Copy NumberKim, Eun-Hye; Kim, Seunghoon; Kim, Hyun-Joo, et alARTICLE55 Prediction of Chronic Periodontitis Severity Using Machine Learning Models Based On Salivary Bacterial Copy Number
2020-09Defining the mutation signatures of DNA polymerase θ in cancer genomesHwang, Taejoo; Reh, Shelley; Dunbayev, Yerkin, et alARTICLE43 Defining the mutation signatures of DNA polymerase θ in cancer genomes
2020-08The whale shark genome reveals how genomic and physiological properties scale with body sizeWeber, Jessica A.; Park, Seung Gu; Luria, Victor, et alARTICLE75 The whale shark genome reveals how genomic and physiological properties scale with body size
2020-07ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication forkKim, Sangin; Kang, Nalae; Park, Su Hyung, et alARTICLE123 ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork
2020-06Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasisChoi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et alARTICLE274 Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-05Korean Genome Project: 1,094 Korean personal genomes with clinical informationJeon, Sungwon; Bhak, Youngjune; Choi, Yeonsong, et alARTICLE520 Korean Genome Project: 1,094 Korean personal genomes with clinical information
2020-05Decoding a highly mixed Kazakh genomeSeidualy, Madina; Blazyte, Asta; Jeon, Sungwon, et alARTICLE202 Decoding a highly mixed Kazakh genome
2020-04A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLCLim, Minji; Park, Juhee; Lowe, Alarice C., et alARTICLE291 A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC
2020-02Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancerLee, Yu Geon; Nam, Yeji; Shin, Kyeong Jin, et alARTICLE312 Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer
2019-12Chromosome-scale assembly comparison of the Korean Reference Genome KOREF from PromethION and PacBio with Hi-C mapping informationKim, Hui-Su; Jeon, Sungwon; Kim, Changjae, et alARTICLE216 Chromosome-scale assembly comparison of the Korean Reference Genome KOREF from PromethION and PacBio with Hi-C mapping information
2019-11CPEM: Accurate cancer type classification based on somatic alterations using an ensemble of a random forest and a deep neural networkLee, Kanggeun; Jeong, Hyoung-oh; Lee, Semin, et alARTICLE271 CPEM: Accurate cancer type classification based on somatic alterations using an ensemble of a random forest and a deep neural network
2019-10Depression and suicide risk prediction models using blood-derived multi-omics dataBhak, Youngjune; Jeong, Hyoung-oh; Cho, Yun Sung, et alARTICLE608 Depression and suicide risk prediction models using blood-derived multi-omics data
2019-10Global impact of somatic structural variation on the DNA methylome of human cancersZhang, Yiqun; Yang, Lixing; Kucherlapati, Melanie, et alARTICLE201 Global impact of somatic structural variation on the DNA methylome of human cancers
2019-08An enhanced genetic model of colorectal cancer progression historyYang, Lixing; Wang, Su; Lee, Jake June-Koo, et alARTICLE236 An enhanced genetic model of colorectal cancer progression history
2018-09Potential involvement of Drosophila flightless-1 in carbohydrate metabolismPark, Jung-Eun; Jang, Jinho; Lee, Eun Ji, et alARTICLE332 Potential involvement of Drosophila flightless-1 in carbohydrate metabolism

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