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Lee, Semin (이세민)

Department
Department of Biomedical Engineering(바이오메디컬공학과)
Website
http://compbio.unist.ac.kr
Lab
Computational Biology Lab. (계산생물학 실험실)
Research Keywords
구조생명정보학, 기계학습, 정밀의학, 암유전체학, 단일세포오믹스, Cancer genomics, single-cell omics, structural bioinformatics, machine learning, precision medicine
Research Interests
We analyze a large number of cancer genomes using multiple omics approaches to characterize various kinds of germline/somatic alterations in many different  human cancer types. In order to understand somatic mosaicism, heterogeneity, and evolution in cancer, we also use single-cell genomics approaches.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2020-08The whale shark genome reveals how genomic and physiological properties scale with body sizeWeber, Jessica A.; Park, Seung Gu; Luria, Victor, et alARTICLE28 The whale shark genome reveals how genomic and physiological properties scale with body size
2020-07ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication forkKim, Sangin; Kang, Nalae; Park, Su Hyung, et alARTICLE29 ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork
2020-06Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasisChoi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et alARTICLE168 Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-05Korean Genome Project: 1,094 Korean personal genomes with clinical informationJeon, Sungwon; Bhak, Youngjune; Choi, Yeonsong, et alARTICLE423 Korean Genome Project: 1,094 Korean personal genomes with clinical information
2020-04A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLCLim, Minji; Park, Juhee; Lowe, Alarice C., et alARTICLE167 A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC
2020-02Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancerLee, Yu Geon; Nam, Yeji; Shin, Kyeong Jin, et alARTICLE208 Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer
2020-02Decoding a highly mixed Kazakh genomeSeidualy, Madina; Blazyte, Asta; Jeon, Sungwon, et alARTICLE120 Decoding a highly mixed Kazakh genome
2019-12Chromosome-scale assembly comparison of the Korean Reference Genome KOREF from PromethION and PacBio with Hi-C mapping informationKim, Hui-Su; Jeon, Sungwon; Kim, Changjae, et alARTICLE161 Chromosome-scale assembly comparison of the Korean Reference Genome KOREF from PromethION and PacBio with Hi-C mapping information
2019-11CPEM: Accurate cancer type classification based on somatic alterations using an ensemble of a random forest and a deep neural networkLee, Kanggeun; Jeong, Hyoung-oh; Lee, Semin, et alARTICLE201 CPEM: Accurate cancer type classification based on somatic alterations using an ensemble of a random forest and a deep neural network
2019-10Depression and suicide risk prediction models using blood-derived multi-omics dataBhak, Youngjune; Jeong, Hyoung-oh; Cho, Yun Sung, et alARTICLE521 Depression and suicide risk prediction models using blood-derived multi-omics data
2019-10Global impact of somatic structural variation on the DNA methylome of human cancersZhang, Yiqun; Yang, Lixing; Kucherlapati, Melanie, et alARTICLE141 Global impact of somatic structural variation on the DNA methylome of human cancers
2019-08An enhanced genetic model of colorectal cancer progression historyYang, Lixing; Wang, Su; Lee, Jake June-Koo, et alARTICLE186 An enhanced genetic model of colorectal cancer progression history
2018-09Potential involvement of Drosophila flightless-1 in carbohydrate metabolismPark, Jung-Eun; Jang, Jinho; Lee, Eun Ji, et alARTICLE286 Potential involvement of Drosophila flightless-1 in carbohydrate metabolism
2018-07A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 CasesZhang, Yiqun; Yang, Lixing; Kucherlapati, Melanie, et alARTICLE310 A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases
2018-06Genomic analysis reveals secondary glioblastoma after radiotherapy in a subset of recurrent medulloblastomasPhi, Ji Hoon; Park, Ae Kyung; Lee, Semin, et alARTICLE619 Genomic analysis reveals secondary glioblastoma after radiotherapy in a subset of recurrent medulloblastomas
2018-06Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq dataFan, Jean; Lee, Hae-Ock; Lee, Soohyun, et alARTICLE276 Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data
2018-04KoVariome: Korean National Standard Reference Variome database of whole genomes with comprehensive SNV, indel, CNV, and SV analysesKim, Jungeun; Weber, Jessica A.; Jho, Sungwoong, et alARTICLE494 KoVariome: Korean National Standard Reference Variome database of whole genomes with comprehensive SNV, indel, CNV, and SV analyses
2017-08Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal MelanomaRobertson, A. Gordon; Shih, Juliann; Yau, Christina, et alARTICLE372 Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
2017-06A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway AlterationsZhang, Yiqun; Ng, Patrick Kwok-Shing; Kucherlapati, Melanie, et alARTICLE504 A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
2017-03Integrated genomic and molecular characterization of cervical cancerThe Cancer Genome Atlas Research Network; Lee, SeminARTICLE628 Integrated genomic and molecular characterization of cervical cancer

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