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Myung, Kyungjae (명경재)

Department
Department of Biomedical Engineering(바이오메디컬공학과)
Website
http://cgi.ibs.re.kr/html/cgi_en
Lab
Center for Genomic Integrity (분자세포생물학실험실)
Research Keywords
유전자 가위, 합성치사이용 항암제 개발, DNA 손상복구, DNA 재조합 복구, DNA 복제, DNA 손상 신호 전달, 암, 노화, Synthetic lethality, DNA Repair, DNA Recombination, ATAD5, PCNA, CRISPR, CRISPR Cas9, DNA Replication, DNA Damage Response, cancer, Aging
Research Interests
DNA is the building block for the genome and provides the blueprint for almost every aspect of life. DNA can be damaged by endogenous assaults such as replication errors, oxidative stress or by exogenous challenges such as radiation or toxic chemicals. Failure to repair such damage results in cell death or the accumulation of changes in DNA that can cause genetic diseases including cancers or can lead to premature aging.Research at the IBS Center for Genomic Integrity is concerned with the many DNA damage response and repair pathways that can sense and repair damaged DNA and signal to cells that there is an urgent problem to be addressed. We also study the link of these pathways to other parts of cellular metabolism, including DNA replication, cell cycle regulation or transcription.Our research spans many disciplines and techniques, including molecular, cell, chemical and structural biology, genetics, biochemistry and the use of animal models. Finally, we are interested in leveraging our research to develop small molecule modulators of DNA repair pathways as probes and to exploit vulnerabilities of tumors in therapeutic settings.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2022-08GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary baseJang, Dong Gil; Kwon, Keun Yeong; Kweon, Yeong Cheon, et alARTICLE43 GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base
2022-06Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expressionByun, Seongjun; Lee, Chan Hyeong; Jeong, Hyumgmin, et alARTICLE223 Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression
2022-06Distinct Motifs in ATAD5 C-Terminal Domain Modulate PCNA Unloading ProcessRyu, Eunjin; Ha, Na Young; Jung, Woojae, et alARTICLE12 Distinct Motifs in ATAD5 C-Terminal Domain Modulate PCNA Unloading Process
2022-05O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucineKim, Kibum; Yoo, Hee Chan; Kim, Byung Gyu, et alARTICLE25 O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine
2022-03Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9Kwon, Taejoon; Ra, Jae Sun; Lee, Soyoung, et alARTICLE433 Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9
2022-03Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemiaPark, Kibeom; Yoo, Hee-Seop; Oh, Chang-Kyu, et alARTICLE221 Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia
2022-02Synthesis of α,β-unsaturated ketones through nickel-catalysed aldehyde-free hydroacylation of alkynesRhlee, Joon Ho; Saikat, Maiti; Lee, Jeong Woo, et alARTICLE205 Synthesis of α,β-unsaturated ketones through nickel-catalysed aldehyde-free hydroacylation of alkynes
2022-01Tissue-specific DNA damage response in Mouse Whole-body irradiationLee, Seon-Gyeong; Kim, Namwoo; Park, In Bae, et alARTICLE173 Tissue-specific DNA damage response in Mouse Whole-body irradiation
2022-01Crosstalk between different DNA repair pathways for DNA double strand break repairsOh, Jung-Min; Myung, KyungjaeARTICLE9 Crosstalk between different DNA repair pathways for DNA double strand break repairs
2021-12Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding SiteYoon, Nam Gu; Lee, Hakbong; Kim, So-Yeon, et alARTICLE242 Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site
2021-11Characterization of subcellular localization of eukaryotic clamp loader/unloader and its regulatory mechanismPark, Su Hyung; Kim, Seong-jung; Myung, Kyungjae, et alARTICLE122 Characterization of subcellular localization of eukaryotic clamp loader/unloader and its regulatory mechanism
2021-11Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genesShin, Unbeom; Nakhro, Khriezhanuo; Oh, Chang-Kyu, et alARTICLE123 Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes
2021-11Timely termination of repair DNA synthesis by ATAD5 is important in oxidative DNA damage-induced single-strand break repairPark, Su Hyung; Kim, Youyoung; Ra, Jae Sun, et alARTICLE225 Timely termination of repair DNA synthesis by ATAD5 is important in oxidative DNA damage-induced single-strand break repair
2021-10Thrap3 promotes R-loop resolution via interaction with methylated DDX5Kang, Hyun Je; Eom, Hye-jin; Kim, Hongtae, et alARTICLE577 Thrap3 promotes R-loop resolution via interaction with methylated DDX5
2021-09SOCS3 is Related to Cell Proliferation in Neuronal Tissue: An Integrated Analysis of Bioinformatics and ExperimentsYu, Yeuni; Sung, Soon Ki; Lee, Chi Hyung, et alARTICLE123 SOCS3 is Related to Cell Proliferation in Neuronal Tissue: An Integrated Analysis of Bioinformatics and Experiments
2021-09Neuropeptide Y: a potential theranostic biomarker for diabetic peripheral neuropathy in patients with type-2 diabetesCho, Noo Ree; Yu, Yeuni; Oh, Chang-Kyu, et alARTICLE107 Neuropeptide Y: a potential theranostic biomarker for diabetic peripheral neuropathy in patients with type-2 diabetes
2021-06NSMF promotes the replication stress-induced DNA damage response for genome maintenanceJu, Min Kyung; Shin, Kyeong Jin; Lee, Joo Rak, et alARTICLE432 NSMF promotes the replication stress-induced DNA damage response for genome maintenance
2021-04AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferationKang, Ji Wan; Kim, Youngjoo; Lee, Yoonsung, et alARTICLE218 AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation
2021-01TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolutionKang, Hyun Je; Cheon, Na Young; Park, Hyun, et alARTICLE434 TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution
2021-01FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrityOh, Chang-Kyu; Ko, Yeji; Park, Jeong Jun, et alARTICLE100 FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity

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