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Myung, Kyungjae (명경재)

Department
Department of Biomedical Engineering(바이오메디컬공학과)
Website
http://cgi.ibs.re.kr/html/cgi_en
Lab
Center for Genomic Integrity (분자세포생물학실험실)
Research Keywords
유전자 가위, 합성치사이용 항암제 개발, DNA 손상복구, DNA 재조합 복구, DNA 복제, DNA 손상 신호 전달, 암, 노화, Synthetic lethality, DNA Repair, DNA Recombination, ATAD5, PCNA, CRISPR, CRISPR Cas9, DNA Replication, DNA Damage Response, cancer, Aging
Research Interests
DNA is the building block for the genome and provides the blueprint for almost every aspect of life. DNA can be damaged by endogenous assaults such as replication errors, oxidative stress or by exogenous challenges such as radiation or toxic chemicals. Failure to repair such damage results in cell death or the accumulation of changes in DNA that can cause genetic diseases including cancers or can lead to premature aging.Research at the IBS Center for Genomic Integrity is concerned with the many DNA damage response and repair pathways that can sense and repair damaged DNA and signal to cells that there is an urgent problem to be addressed. We also study the link of these pathways to other parts of cellular metabolism, including DNA replication, cell cycle regulation or transcription.Our research spans many disciplines and techniques, including molecular, cell, chemical and structural biology, genetics, biochemistry and the use of animal models. Finally, we are interested in leveraging our research to develop small molecule modulators of DNA repair pathways as probes and to exploit vulnerabilities of tumors in therapeutic settings.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2021-05NSMF promotes the replication stress-induced DNA damage response for genome maintenanceJu, Min Kyung; Shin, Kyeong Jin; Lee, Joo Rak, et alARTICLE3 NSMF promotes the replication stress-induced DNA damage response for genome maintenance
2021-01TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolutionKang, Hyun Je; Cheon, Na Young; Park, Hyun, et alARTICLE144 TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution
2020-12O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson diseaseLee, Byeong Eun; Kim, Hye Yun; Kim, Hyun-Jin, et alARTICLE230 O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease
2020-12Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16hEspanola, Sophia G.; Song, Hyemin; Ryu, Eunjin, et alARTICLE77 Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h
2020-11Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatinLee, Seon-gyeong; Kim, Namwoo; Kim, Su-min, et alARTICLE75 Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatin
2020-11Exploring the Role of a Novel Peptide from Allomyrina dichotoma Larvae in Ameliorating Lipid Metabolism in ObesityBae, Sung Mun; Fan, Meiqi; Choi, Young-Jin, et alARTICLE48 Exploring the Role of a Novel Peptide from Allomyrina dichotoma Larvae in Ameliorating Lipid Metabolism in Obesity
2020-11AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferationKang, Ji Wan; Kim, Youngjoo; Lee, Yoonsung, et alARTICLE34 AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation
2020-09Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophoreChaudhary, Narendra; Nho, Si-Hyeong; Cho, Hayoon, et alARTICLE76 Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophore
2020-08ATAD5 suppresses centrosome over-duplication by regulating UAF1 and ID1Kim, Seong-jung; Wie, Minwoo; Park, Su Hyung, et alARTICLE96 ATAD5 suppresses centrosome over-duplication by regulating UAF1 and ID1
2020-08FAM213A is linked to prognostic significance in acute myeloid leukemia through regulation of oxidative stress and myelopoiesisOh, Chang-Kyu; Ha, Mihyang; Han, Myoung-Eun, et alARTICLE44 FAM213A is linked to prognostic significance in acute myeloid leukemia through regulation of oxidative stress and myelopoiesis
2020-07ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication forkKim, Sangin; Kang, Nalae; Park, Su Hyung, et alARTICLE123 ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork
2020-06Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasisChoi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et alARTICLE274 Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-05Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in ZebrafishOh, Chang-Kyu; Kang, Ji Wan; Lee, Yoonsung, et alARTICLE77 Role of kif2c, A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish
2020-01Simple Method To Characterize the Ciliary Proteome of Multiciliated CellsSim, Hyo Jung; Yun, Seongmin; Kim, Ha Eun, et alARTICLE247 Simple Method To Characterize the Ciliary Proteome of Multiciliated Cells
2019-12GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemiaHan, Seung Hun; Korm, Sovannarith; Han, Ye Gi, et alARTICLE345 GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia
2019-12PCNA Unloading Is Negatively Regulated by BET ProteinsKang, Mi-Sun; Kim, Jinwoo; Ryu, Eunjin, et alARTICLE224 PCNA Unloading Is Negatively Regulated by BET Proteins
2019-12ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stressPark, Su Hyung; Kang, Nalae; Song, Eunho, et alARTICLE313 ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
2019-09CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaksHwang, Soon Young; Kang, Mi Ae; Baik, Chul Joon, et alARTICLE321 CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks
2019-09TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1Kang, Hyun Je; Park, Hyun; Yoo, Eun Jin, et alARTICLE285 TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
2019-07The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordinationPark, Jumi; Lee, Song-Yi; Jeong, Hanbin, et alARTICLE415 The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordination

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