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Myung, Kyungjae (명경재)

Department
Department of Biomedical Engineering(바이오메디컬공학과)
Website
http://cgi.ibs.re.kr/html/cgi_en
Lab
Center for Genomic Integrity (분자세포생물학실험실)
Research Keywords
유전자 가위, 합성치사이용 항암제 개발, DNA 손상복구, DNA 재조합 복구, DNA 복제, DNA 손상 신호 전달, 암, 노화, Synthetic lethality, DNA Repair, DNA Recombination, ATAD5, PCNA, CRISPR, CRISPR Cas9, DNA Replication, DNA Damage Response, cancer, Aging
Research Interests
DNA is the building block for the genome and provides the blueprint for almost every aspect of life. DNA can be damaged by endogenous assaults such as replication errors, oxidative stress or by exogenous challenges such as radiation or toxic chemicals. Failure to repair such damage results in cell death or the accumulation of changes in DNA that can cause genetic diseases including cancers or can lead to premature aging.Research at the IBS Center for Genomic Integrity is concerned with the many DNA damage response and repair pathways that can sense and repair damaged DNA and signal to cells that there is an urgent problem to be addressed. We also study the link of these pathways to other parts of cellular metabolism, including DNA replication, cell cycle regulation or transcription.Our research spans many disciplines and techniques, including molecular, cell, chemical and structural biology, genetics, biochemistry and the use of animal models. Finally, we are interested in leveraging our research to develop small molecule modulators of DNA repair pathways as probes and to exploit vulnerabilities of tumors in therapeutic settings.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2020-11O-GlcNAcylation regulates dopamine neuron function, survival, and degeneration in Parkinson diseaseLee, Byeong Eun; Kim, Hye Yun; Kim, Hyun-Jin, et alARTICLE47 O-GlcNAcylation regulates dopamine neuron function, survival, and degeneration in Parkinson disease
2020-10Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatinLee, Seon-gyeong; Kim, Namwoo; Kim, Su-min, et alARTICLE11 Ewing sarcoma protein promotes dissociation of poly(ADP-ribose) polymerase 1 from chromatin
2020-09Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophoreChaudhary, Narendra; Nho, Si-Hyeong; Cho, Hayoon, et alARTICLE30 Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophore
2020-07ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication forkKim, Sangin; Kang, Nalae; Park, Su Hyung, et alARTICLE26 ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork
2020-06Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasisChoi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et alARTICLE164 Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-01Simple Method To Characterize the Ciliary Proteome of Multiciliated CellsSim, Hyo Jung; Yun, Seongmin; Kim, Ha Eun, et alARTICLE177 Simple Method To Characterize the Ciliary Proteome of Multiciliated Cells
2019-12GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemiaHan, Seung Hun; Korm, Sovannarith; Han, Ye Gi, et alARTICLE276 GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia
2019-12PCNA Unloading Is Negatively Regulated by BET ProteinsKang, Mi-Sun; Kim, Jinwoo; Ryu, Eunjin, et alARTICLE157 PCNA Unloading Is Negatively Regulated by BET Proteins
2019-12ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stressPark, Su Hyung; Kang, Nalae; Song, Eunho, et alARTICLE226 ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress
2019-09CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaksHwang, Soon Young; Kang, Mi Ae; Baik, Chul Joon, et alARTICLE255 CTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks
2019-09TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1Kang, Hyun Je; Park, Hyun; Yoo, Eun Jin, et alARTICLE210 TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
2019-07The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordinationPark, Jumi; Lee, Song-Yi; Jeong, Hanbin, et alARTICLE333 The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordination
2019-06Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexesKang, Mi-Sun; Ryu, Eunjin; Lee, Seung-Won, et alARTICLE274 Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
2019-06Chemoselective Trifluoroethylation Reactions of Quinazolinones and Identification of PhotostabilityMaiti, Saikat; Kim, Jaeshin; Park, Jae-Heon, et alARTICLE343 Chemoselective Trifluoroethylation Reactions of Quinazolinones and Identification of Photostability
2019-03Hypomorphic Mutations in TONSL Cause SPONASTRIME DysplasiaChang, Hae Ryung; Cho, Sung Yoon; Lee, Jae Hoon, et alARTICLE157 Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia
2019-02Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasisLee, Jun Ho; Suh, Jae Hee; Choi, Soo Youn, et alARTICLE422 Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis
2018-10ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis.Song, Eun Kyung; Jeon, Jimin; Jang, Dong Gil, et alARTICLE462 ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis.
2018-10The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gammaLee, Jae Min; Choi, Sun Sil; Lee, Yo Han, et alARTICLE518 The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gamma
2018-10TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCCKim, Dong Hyun; Han, Joo Seok; Ly, Peter, et alARTICLE289 TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC
2018-05Eukaryotic DNA replication: Orchestrated action of multi-subunit protein complexesKang, Sukhyun; Kang, Mi-Sun; Ryu, Eunjin, et alARTICLE328 Eukaryotic DNA replication: Orchestrated action of multi-subunit protein complexes

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