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Myung, Kyungjae (명경재)

Department
Department of Biomedical Engineering(바이오메디컬공학과)
Website
http://cgi.ibs.re.kr/html/cgi_en
Lab
Center for Genomic Integrity (분자세포생물학실험실)
Research Keywords
유전자 가위, 합성치사이용 항암제 개발, DNA 손상복구, DNA 재조합 복구, DNA 복제, DNA 손상 신호 전달, 암, 노화, Synthetic lethality, DNA Repair, DNA Recombination, ATAD5, PCNA, CRISPR, CRISPR Cas9, DNA Replication, DNA Damage Response, cancer, Aging
Research Interests
DNA is the building block for the genome and provides the blueprint for almost every aspect of life. DNA can be damaged by endogenous assaults such as replication errors, oxidative stress or by exogenous challenges such as radiation or toxic chemicals. Failure to repair such damage results in cell death or the accumulation of changes in DNA that can cause genetic diseases including cancers or can lead to premature aging.Research at the IBS Center for Genomic Integrity is concerned with the many DNA damage response and repair pathways that can sense and repair damaged DNA and signal to cells that there is an urgent problem to be addressed. We also study the link of these pathways to other parts of cellular metabolism, including DNA replication, cell cycle regulation or transcription.Our research spans many disciplines and techniques, including molecular, cell, chemical and structural biology, genetics, biochemistry and the use of animal models. Finally, we are interested in leveraging our research to develop small molecule modulators of DNA repair pathways as probes and to exploit vulnerabilities of tumors in therapeutic settings.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2023-11PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin IIIKim, Hye Yun; Lee, Jieun; Kim, Hyun-Jin, et alARTICLE279 PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III
2023-10GABAergic-like dopamine synapses in the brainKim, Hyun-Jin; Hwang, Byungjae; Reva, Maria, et alARTICLE276 GABAergic-like dopamine synapses in the brain
2023-10Enrichment of Deleterious Mutated Genes Involved in Ciliary Function and Histone Modification in Brain Cancer Patient-Derived Xenograft ModelsJeong, Hyeongsun; Moon, Hyo Eun; Yun, Seongmin, et alARTICLE22 Enrichment of Deleterious Mutated Genes Involved in Ciliary Function and Histone Modification in Brain Cancer Patient-Derived Xenograft Models
2023-09Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumorsWie, Minwoo; Khim, Keon Woo; Groehler Iv, Arnold S, et alARTICLE403 Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors
2023-09Short-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombinationPark, Su Hyung; Kim, Namwoo; Kang, Nalae, et alARTICLE264 Short-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombination
2023-08Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagyJang, Hyun-Jun; Lee, Yo Han; Tam, Dao, et alARTICLE1083 Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy
2023-06MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1Oh, Jung-Min; Kang, Yujin; Park, Jumi, et alARTICLE1120 MSH2-MSH3 promotes DNA end resection during homologous recombination and blocks polymerase theta-mediated end-joining through interaction with SMARCAD1 and EXO1
2023-05A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafishShin, Unbeom; Choi, Yeonsong; Ko, Hwa Soo, et alARTICLE488 A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish
2023-05PCNA Ser46-Leu47 residues are crucial in preserving genomic integrityKim, Sangin; Kim, Yeongjae; Kim, Youyoung, et alARTICLE21 PCNA Ser46-Leu47 residues are crucial in preserving genomic integrity
2023-04Isolation and identification of extracellular matrix proteins from oil-based CASPERized mouse brains for matrisomal analysisHa, Byung Geun; Jang, Yu-Jin; Lee, EunSoo, et alARTICLE60 Isolation and identification of extracellular matrix proteins from oil-based CASPERized mouse brains for matrisomal analysis
2023-01ZNF212 promotes genomic integrity through direct interaction with TRAIPChung, Hee Jin; Lee, Joo Rak; Kim, Tae Moon, et alARTICLE1257 ZNF212 promotes genomic integrity through direct interaction with TRAIP
2022-12TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11Jeong, Hyeongsun; Wie, Minwoo; Baek, In-Joon, et alARTICLE727 TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11
2022-12PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repairHo, Yen-Chih; Ku, Chen-Syun; Tsai, Siang-Sheng, et alARTICLE217 PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair
2022-11Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemiaPark, Kibeom; Yoo, Hee-Seop; Oh, Chang-Kyu, et alARTICLE1132 Reciprocal interactions among Cobll1, PACSIN2, and SH3BP1 regulate drug resistance in chronic myeloid leukemia
2022-11Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1Chung, Scisung; Kang, Mi-Sun; Alimbetov, Dauren S., et alARTICLE535 Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1
2022-08GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary baseJang, Dong Gil; Kwon, Keun Yeong; Kweon, Yeong Cheon, et alARTICLE790 GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base
2022-07PWWP2B promotes DNA end resection and homologous recombinationJu, Min Kyung; Lee, Joo Rak; Choi, Yeonsong, et alARTICLE1154 PWWP2B promotes DNA end resection and homologous recombination
2022-06Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expressionByun, Seongjun; Lee, Chan Hyeong; Jeong, Hyumgmin, et alARTICLE626 Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression
2022-06Distinct Motifs in ATAD5 C-Terminal Domain Modulate PCNA Unloading ProcessRyu, Eunjin; Ha, Na Young; Jung, Woojae, et alARTICLE218 Distinct Motifs in ATAD5 C-Terminal Domain Modulate PCNA Unloading Process
2022-05O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucineKim, Kibum; Yoo, Hee Chan; Kim, Byung Gyu, et alARTICLE340 O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine

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