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Ko, Myunggon (고명곤)

Department
Department of Biological Sciences(생명과학과)
Website
https://myunggonko.wixsite.com/mgko
Lab
Cancer Epigenetics Lab. (종양후생유전학 연구실)
Research Keywords
Leukemia, hematopoiesis, obesity, diabetes, metabolic disease, cancer therapy, cancer
Research Interests
How do alterations in epigenetic landscape disturb the barrier between normal and malignant states to cause cancers? How can we translate these cancer-related aberrations into more efficient cancer therapy? These are two overarching questions that our research is currently addressing. The intricate interplay between genetic and epigenetic pathways plays key roles in regulating normal and malignant cellular development.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2023-09Editorial for the Special Issue “Molecular Mechanism of Leukemia”An, Jungeun; Ko, MyunggonARTICLE126 Editorial for the Special Issue “Molecular Mechanism of Leukemia”
2023-07Pharmacological GLUT3 salvage augments the efficacy of vitamin C-induced TET2 restoration in acute myeloid leukemiaLiu, Jun; Min, Suji; Kim, Dongchan, et alARTICLE540 Pharmacological GLUT3 salvage augments the efficacy of vitamin C-induced TET2 restoration in acute myeloid leukemia
2023-03Highly selective and real-time detection of 5-hydroxymethylcytosine in genomic DNA using a carbon nitride-modified gold transducer-based electrochemical sensorImran, Habibulla; An, Jungeun; Jang, Kyumin, et alARTICLE1567 Highly selective and real-time detection of 5-hydroxymethylcytosine in genomic DNA using a carbon nitride-modified gold transducer-based electrochemical sensor
2023-02Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer TherapyJung, Inkyung; An, Jungeun; Ko, MyunggonARTICLE735 Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy
2023-01Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switchYuita, Hiroshi; Lopez-Moyado, Isaac; Jeong, Hyeongmin, et alARTICLE539 Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch
2023-01Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant TransformationKo, Myunggon; An, JungeunARTICLE619 Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant Transformation
2022-11BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cellsJeong, Jinguk; Jung, Inkyung; Kim, Ji-Hoon, et alARTICLE1018 BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells
2022-07A fast and label-free detection of hydroxymethylated DNA using a nozzle-jet printed AuNPs@Ti3C2 MXene-based electrochemical sensorBhat, Kiesar Sideeq; Byun, Seongjun; Alam, Asrar, et alARTICLE810 A fast and label-free detection of hydroxymethylated DNA using a nozzle-jet printed AuNPs@Ti3C2 MXene-based electrochemical sensor
2022-06Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expressionByun, Seongjun; Lee, Chan Hyeong; Jeong, Hyumgmin, et alARTICLE582 Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression
2021-11Rapid and Label-Free Detection of 5-Hydroxymethylcytosine in Genomic DNA Using an Au/ZnO Nanorods Hybrid Nanostructure-Based Electrochemical SensorBhat, Kiesar Sideeq; Kim, Hyejin; Alam, Asrar, et alARTICLE630 Rapid and Label-Free Detection of 5-Hydroxymethylcytosine in Genomic DNA Using an Au/ZnO Nanorods Hybrid Nanostructure-Based Electrochemical Sensor
2020-12Direct and rapid detection of 5-hydroxymethylcytosine, a novel cancer hallmark in DNA, using electrochemical reactionLee, Seo Yeon; Qi, Xu; Ko, Myunggon, et alARTICLE819 Direct and rapid detection of 5-hydroxymethylcytosine, a novel cancer hallmark in DNA, using electrochemical reaction
2020-06Decoding ribosomes to keep growing (in AML)An, Jungeun; Ko, MyunggonARTICLE590 Decoding ribosomes to keep growing (in AML)
2020-05Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restorationLiu, Jun; Hong, Junshik; Han, Heejoo, et alARTICLE675 Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration
2017-04TET family dioxygenases and DNA demethylation in stem cells and cancersAn, Jungeun; Rao, Anjana; Ko, MyunggonARTICLE1060 TET family dioxygenases and DNA demethylation in stem cells and cancers
2016-12DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA MethyltransferasesNair, Varun Sasidharan; Song, Mi Hye; Ko, Myunggon, et alARTICLE1043 DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases
2016-09DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cellsZhang, Xiaotian; Su, Jianzhong; Jeong, Mira, et alARTICLE1357 DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
2016-05TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic ActivitiesMontagner, Sara; Leoni, Cristina; Emming, Stefan, et alARTICLE1082 TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities
2015-12DNA methylation and hydroxymethylation in hematologic differentiation and transformationKo, Myunggon; An, Jungeun; Rao, AnjanaARTICLE1641 DNA methylation and hydroxymethylation in hematologic differentiation and transformation
2015-11Acute loss of TET function results in aggressive myeloid cancer in miceAn, Jungeun; Gonzalez-Avalos, E.; Chawla, Ashu, et alARTICLE1348 Acute loss of TET function results in aggressive myeloid cancer in mice
2015-11Functions of TET Proteins in Hematopoietic TransformationHan, Jae-A; An, Jungeun; Ko, MyunggonARTICLE1289 Functions of TET Proteins in Hematopoietic Transformation

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