사진

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Kim, Hajin (김하진)

Department
Department of Biomedical Engineering(바이오메디컬공학과)
Website
http://single.unist.ac.kr/
Lab
Single Molecule Biophysics Lab. (단분자 생물물리학 연구실)
Research Keywords
Biophysics, biological Motors, Single Molecule Dynamics, fluorescence Spectroscopy, molecular motors, Genome Imaging, Chromatin Dynamics, Super-Resolution Microscopy, Single Molecule Mechanobiology
Research Interests
We look at “Life”, molecule by molecule. Single molecule approaches to biology and biophysics reveal unforeseen details about the building blocks of biology. From these, we can understand the role of fluctuations and the interplay of molecules, to open new insights into the functioning of the biomolecules. These insights can provide novel strategies toward biomedical problems as well as answers to scientific questions. We develop and combine cutting-edge single molecule and single cell techniques to solve important problems in biological science, including the organization and dynamics of chromosomes, biomolecular recognition/assembly, molecular machinery working on nucleic acids, and intrinsically disordered proteins. Our study requires cross-disciplinary efforts from biologists, physicists, chemists, and engineering scientists and we pursue collaborations with groups from diverse scientific disciplines. One of our major interests is to uncover the molecular level principles that govern the spatiotemporal organization of chromatin and its epigenetic control for regulating DNA repair and gene expression, eventually determining the fate of the cell.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2020-09Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophoreChaudhary, Narendra; Nho, Si-Hyeong; Cho, Hayoon, et alARTICLE30 Background-suppressed live visualization of genomic loci with an improved CRISPR system based on a split fluorophore
2020-08The dynamic landscape of transcription initiation in yeast mitochondriaSohn, Byeong-Kwon; Basu, Urmimala; Lee, Seung-Won, et alARTICLE55 The dynamic landscape of transcription initiation in yeast mitochondria
2020-03The C-terminal tail of the yeast mitochondrial transcription factor Mtf1 coordinates template strand alignment, DNA scrunching and timely transition into elongationBasu, Urmimala; Lee, Seung-Won; Deshpande, Aishwarya, et alARTICLE89 The C-terminal tail of the yeast mitochondrial transcription factor Mtf1 coordinates template strand alignment, DNA scrunching and timely transition into elongation
2020-01Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store DepletionQin, Xianan; Liu, Lei; Lee, Sang Kwon, et alARTICLE150 Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion
2019-10Molecular characteristics of reiterative DNA unwinding by the Caenorhabditis elegans RecQ helicaseChoi, Seoyun; Lee, Seung-Won; Kim, Hajin, et alARTICLE174 Molecular characteristics of reiterative DNA unwinding by the Caenorhabditis elegans RecQ helicase
2019-08Subtyping of influenza A H1N1 virus using a label-free electrochemical biosensor based on the DNA aptamer targeting the stem region of HA proteinBhardwaj, Jyoti; Chaudhary, Narendra; Kim, Hajin, et alARTICLE354 Subtyping of influenza A H1N1 virus using a label-free electrochemical biosensor based on the DNA aptamer targeting the stem region of HA protein
2019-06Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexesKang, Mi-Sun; Ryu, Eunjin; Lee, Seung-Won, et alARTICLE275 Regulation of PCNA cycling on replicating DNA by RFC and RFC-like complexes
2018-10Sequence-dependent DNA condensation as a driving force of DNA phase separationKang, Hyunju; Yoo, Jejoong; Sohn, Byeong-Kwon, et alARTICLE503 Sequence-dependent DNA condensation as a driving force of DNA phase separation
2017-09Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexesAbeysirigunawardena, Sanjaya C.; Kim, Hajin; Lai, Jonathan, et alARTICLE452 Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes
2016-10Integrative Approach toward Uncovering the Origin of Photoluminescence in Dual Heteroatom-Doped Carbon NanodotsChoi, Yuri; Kang, Byungkyun; Lee, Jooyong, et alARTICLE676 Integrative Approach toward Uncovering the Origin of Photoluminescence in Dual Heteroatom-Doped Carbon Nanodots
2016-03Direct evidence for sequence-dependent attraction between double-stranded DNA controlled by methylationYoo, Jejoong; Kim, Hajin; Aksimentiev, Aleksei, et alARTICLE647 Direct evidence for sequence-dependent attraction between double-stranded DNA controlled by methylation
2015-06A parameter estimation method for fluorescence lifetime data BioinformaticsSewell, Daniel; Kim, Hajin; Ha, Taek Jip, et alARTICLE550 A parameter estimation method for fluorescence lifetime data Bioinformatics
2014-12An improved surface passivation method for single-molecule studiesHua, Boyang; Han, Kyu Young; Zhou, Ruobo, et alARTICLE751 An improved surface passivation method for single-molecule studies
2014-02Protein-guided RNA dynamics during early ribosome assemblyKim, Hajin; Abeysirigunawarden, Sanjaya C.; Chen, Ke, et alARTICLE694 Protein-guided RNA dynamics during early ribosome assembly
2013-07Single-molecule FRET reveals the native-state dynamics of the IκBα ankyrin repeat domainLamboy, Jorge A.; Kim, Hajin; Dembinski, Holly, et alARTICLE646 Single-molecule FRET reveals the native-state dynamics of the IκBα ankyrin repeat domain
2013-01Single-molecule nanometry for biological physicsKim, Hajin; Ha, TaekjipARTICLE297 Single-molecule nanometry for biological physics
2012-06A rule of seven in Watson-Crick base-pairing of mismatched sequencesCisse, Ibrahim I.; Kim, Hajin; Ha, TaekjipARTICLE574 A rule of seven in Watson-Crick base-pairing of mismatched sequences
2012-06Assembly of the Five-Way Junction in the Ribosomal Small Subunit Using Hybrid MD-Go SimulationsChen, Ke; Eargle, John; Lai, Jonathan, et alARTICLE650 Assembly of the Five-Way Junction in the Ribosomal Small Subunit Using Hybrid MD-Go Simulations
2012-01Opening-closing dynamics of the mitochondrial transcription pre-initiation complexKim, Hajin; Tang, Guo-Qing; Patel, Smita S., et alARTICLE613 Opening-closing dynamics of the mitochondrial transcription pre-initiation complex
2011-06Visualization of the nanospring dynamics of the I kappa B alpha ankyrin repeat domain in real timeLamboy, Jorge A.; Kim, Hajin; Lee, Kyung Suk, et alARTICLE543 Visualization of the nanospring dynamics of the I kappa B alpha ankyrin repeat domain in real time

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