사진

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Park, Chan Young (박찬영)

Department
Department of Biological Sciences(생명과학과)
Website
http://www.chanyounglab.com
Lab
Calcium Dynamics Lab. (칼슘다이나믹스 연구실)
Research Keywords
Medical Science, autoimmune diseases, immune system activation, calcium signaling, translational medicine
Research Interests
The goal of our research is to understand how calcium signaling is important and diverse. Numerous vital physiological processes such as cell division, proliferation, apoptosis, gene transcription, and immune cell activation are regulated by calcium channels. Consequently, calcium channels are important for many pathological processes and diseases including autism, immune deficiency syndrome, and cardiovascular diseases. We are interested in the dynamic calcium signaling events mediated by voltage-gated calcium channels (VGCCs) and store-operated calcium channels (SOCs).Another goal is to provide effective solutions designed to boost your ability, to ensure you achieve your dreams of success, and to help you be a nice lab citizen.​
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2020-06Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasisChoi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et alARTICLE168 Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-01IDstim helps STIM1 keep inactive via intramolecular binding to the coiled-coil domain in a resting stateLee, Sang Kwon; Lee, Min-hsun; Jeong, Su Ji, et alARTICLE158 IDstim helps STIM1 keep inactive via intramolecular binding to the coiled-coil domain in a resting state
2020-01Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store DepletionQin, Xianan; Liu, Lei; Lee, Sang Kwon, et alARTICLE150 Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion
2019-07Orai1 inhibitor STIM2β regulates myogenesis by controlling SOCE dependent transcriptional factorsKim, Kyu Min; Rana, Anshul; Park, Chan YoungARTICLE258 Orai1 inhibitor STIM2β regulates myogenesis by controlling SOCE dependent transcriptional factors
2018-10ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis.Song, Eun Kyung; Jeon, Jimin; Jang, Dong Gil, et alARTICLE471 ITGBL1 modulates integrin activity to promote cartilage formation and protect against arthritis.
2018-05Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegansKim, Kyu Min; Wijerathne, Tharaka; Hur, Jin-Hoe, et alARTICLE574 Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans
2017-08Molecular interactions of autophagy with the immune system and cancerJin, Yunho; Hong, Yunkyung; Park, Chan Young, et alARTICLE565 Molecular interactions of autophagy with the immune system and cancer
2016-07A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair DeficienciesZhang, Yongliang; Fox, Jennifer T.; Park, Young-Un, et alARTICLE826 A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies
2016-02Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline grapheneLee, Hyunah; Nam, Donggyu; Choi, Jae Kyung, et alARTICLE1166 Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene
2015-06Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channelsPark, Chan Young; Dolmetsch, Ricardo E.; Lewis, Richard S., et alARTICLE834 Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels
2014-10Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarraysSadaghiani, Amir Masoud Sadaghiani; Lee, Sang Min; Odegaard, Justin I., et alARTICLE872 Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays
2014-06REGNET: Mining context-specific human transcription networks using composite genomic informationChi, Sang-Mun; Seo, Young Kyo; Park, Young-Kyu, et alARTICLE1001 REGNET: Mining context-specific human transcription networks using composite genomic information
2012-11Constitutive expression of mammalian nitric oxide synthase in tobacco plants triggers disease resistance to pathogensPark, Chan Young; Chun, Hyun Jin; Park, Hyeong Cheol, et alARTICLE925 Constitutive expression of mammalian nitric oxide synthase in tobacco plants triggers disease resistance to pathogens
2010-11AtCML8, a calmodulin-like protein, differentially activating CaM-dependent enzymes in Arabidopsis thalianaPark, Hyeong Cheol; Park, Chan Young; Koo, Sung Cheol, et alARTICLE730 AtCML8, a calmodulin-like protein, differentially activating CaM-dependent enzymes in Arabidopsis thaliana
2010-10The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channelsPark, Chan Young; Shcheglovitov, Aleksandr; Dolmetsch, RicardoARTICLE896 The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels
2009-10Gabapentin Receptor alpha 2 delta-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS SynaptogenesisEroglu, Cagla; Allen, Nicola J.; Susman, Michael W., et alARTICLE772 Gabapentin Receptor alpha 2 delta-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
2009-09STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channelsMullins, Franklin M.; Park, Chan Young; Dolmetsch, Ricardo E., et alARTICLE723 STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels
2009-03STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1Park, Chan Young; Hoover, Paul J.; Mullins, Franklin M., et alARTICLE822 STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1
2006-10The double life of a transcription factor takes it outside the nucleusPark, Chan Young; Dolmetsch, RichardARTICLE650 The double life of a transcription factor takes it outside the nucleus
2005-07Arabidopsis ubiquitin-specific protease 6 (AtUBP6) interacts with calmodulinMoon, BC; Choi, MS; Kang, YH, et alARTICLE775 Arabidopsis ubiquitin-specific protease 6 (AtUBP6) interacts with calmodulin

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