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Kang, Byoung Heon (강병헌)

Department
Department of Biological Sciences(생명과학과)
Website
https://sites.google.com/site/mitomed/
Lab
Cancer Biology Lab. (암생물학 실험실)
Research Keywords
암생물학, 미토콘드리아 샤페론, 세포죽음, 대사, 암줄기세포, 항암치료제, Mitochondrial chaperones, cancer biology, cell death, metabolism, cancer stem cells, cancer therapeutics development
Research Interests
Mitochondria are critical cellular regulatory nodal points intersecting multiple regulatory pathways of cell death and metabolism. The mitochondrial chaperone TRAP1 has been reported to regulate mitochondrial cell death and metabolism. We are interested in elucidation of TRAP1 functions in cancer cell and cancer stem cells, and development of mitochondria-targeted or mitochondria-permeable TRAP1 inhibitors, SMTIN and panvotinib, respectively.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2021-12Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding SiteYoon, Nam Gu; Lee, Hakbong; Kim, So-Yeon, et alARTICLE130 Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site
2021-07Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog SelectivityYang, Sujae; Yoon, Nam Gu; Kim, Dongyoung, et alARTICLE119 Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity
2020-08Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft modelsKim, Darong; Kim, So-Yeon; Kim, Dongyoung, et alARTICLE211 Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models
2020-06Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasisChoi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et alARTICLE495 Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-03Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting DrugHu, Sung; Ferraro, Mariarosaria; Thomas, Ajesh P., et alARTICLE257 Dual Binding to Orthosteric and Allosteric Sites Enhances the Anticancer Activity of a TRAP1-Targeting Drug
2020-01Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1Jung, Sejin; Yoon, Nam Gu; Yang, Sujae, et alARTICLE282 Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1
2020-01Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1Park, Hye-Kyung; Yoon, Nam Gu; Lee, Ji-Eun, et alARTICLE441 Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
2019-10Mitochondrial Heat Shock Protein-Guided Photodynamic TherapyThomas, Ajesh P.; Lee, An-Jung; Palanikumar, L, et alARTICLE414 Mitochondrial Heat Shock Protein-Guided Photodynamic Therapy
2019-04Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cellsPark, Hye-Kyung; Hong, Jun-Hee; Oh, Young Taek, et alARTICLE559 Interplay between TRAP1 and sirtuin-3 modulates mitochondrial respiration and oxidative stress to maintain stemness of glioma stem cells
2018-04TRAP1 Inhibition Increases Glutamine Synthetase Activity in Glutamine Auxotrophic Non-small Cell Lung Cancer CellsVo, Vu T. A.; Choi, Jong-Whan; Phan, Ai N. H., et alARTICLE589 TRAP1 Inhibition Increases Glutamine Synthetase Activity in Glutamine Auxotrophic Non-small Cell Lung Cancer Cells
2017-09Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 InhibitorsPark, Hye-Kyung; Jeong, Hanbin; Ko, Eunhwa, et alARTICLE956 Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors
2017-08The novel resveratrol derivative 3,5-diethoxy-3', 4'-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitroPark, Jae-woo; Choi, Woo-gyun; Lee, Phil-jun, et alARTICLE730 The novel resveratrol derivative 3,5-diethoxy-3', 4'-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro
2015-04Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1Lee, Changwook; Park, Hye-Kyung; Jeong, Hanbin, et alARTICLE1258 Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1
2015-03장수풍뎅이 유충의 간보호 효능 및 항암활성Lee, Ji-Eun; Jo, Da-Eun; Lee, An-Jung, et alARTICLE2638 장수풍뎅이 유충의 간보호 효능 및 항암활성
2015-02Cytotoxic effects of Tenebrio molitor larval extracts against hepatocellular carcinomaLee, ji-Eun; Lee, An-Jung; Jo, Da-Eun, et alARTICLE1578 Cytotoxic effects of Tenebrio molitor larval extracts against hepatocellular carcinoma
2014-12Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitorsKang, Byoung Heon; Jeong, Hanbin; Lee, ChangwookARTICLE1179 Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors
2014-11Hepatoprotective and antineoplastic properties of Protaetia brevitarsis larvaeLee, Ji-Eun; Jo, Da-Eun; Lee, An-Jung, et alARTICLE855 Hepatoprotective and antineoplastic properties of Protaetia brevitarsis larvae
2014-07OGA heterozygosity suppresses intestinal tumorigenesis in Apc min/+ miceYang, Yongryoul; Jang H.J.; Yoon, Sunyoung, et alARTICLE1272 OGA heterozygosity suppresses intestinal tumorigenesis in Apc min/+ mice
2014-06Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cellsPark, Hye-Kyung; Lee, Ji-Eun; Lim, Jaehwa, et alARTICLE907 Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cells
2014-06Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of BimPark, Hye-Kyung; Lee, Ji-Eun; Lim, Jaehwa, et alARTICLE1033 Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim

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