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Choi, Jang Hyun (최장현)

Department: Department of Biological Sciences(생명과학과)

Website: https://ldmunist.wixsite.com/choilab

Lab: Lab of Diabetes and Metabolism Lab. (당뇨 및 대사질환 연구실)

Research Keywords: 당뇨, 대사질환, 유전자조절, Diabetes, Metabolic Disorders, Gene Regulation, PPARg

Research Interests: Obesity is a major risk factor for metabolic diseases such as type 2 diabetes, dyslipidemia, cardiovascular disease and cancers. The number of patients with metabolic diseases rapidly increasing and is reaching the levels of infectious diseases.Our lab is interested in understanding the molecular pathways that link adipose tissue biology to this staggering array of pathologies such as diabetes and metabolic diseases. These studies can be the scientific basis for developing novel anti-diabetic agents.

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Issue Date	Title	Author(s)	Type	View	Altmetrics
2012-06	O-GlcNAcase is essential for embryonic development and maintenance of genomic stability	Yang, Yong Ryoul; Song, Minseok; Lee, Ho, et al	ARTICLE	1294	O-GlcNAcase is essential for embryonic development and maintenance of genomic stability
2012-02	Fibroblast Growth Factor-21 Regulates PPAR gamma Activity and the Antidiabetic Actions of Thiazolidinediones	Dutchak, Paul A.; Katafuchi, Takeshi; Bookout, Angie L., et al	ARTICLE	1123	Fibroblast Growth Factor-21 Regulates PPAR gamma Activity and the Antidiabetic Actions of Thiazolidinediones
2012-01	Diverse cellular and physiological roles of phospholipase C-γ1	Yang, Yong Ryoul; Choi, Jang Hyun; Chang, Jong-Soo, et al	ARTICLE	1298	Diverse cellular and physiological roles of phospholipase C-γ1
2012-01	Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors	Malapaka, Raghu R. V.; Khoo, SokKean; Zhang, Jifeng, et al	ARTICLE	1057	Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors
2012-01	A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis	Bostroem, Pontus; Wu, Jun; Jedrychowski, Mark P., et al	ARTICLE	1296	A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
2011-12	N-Acetylfarnesylcysteine Is a Novel Class of Peroxisome Proliferator-activated Receptor gamma Ligand with Partial and Full Agonist Activity in Vitro and in Vivo	Bhalla, Kavita; Hwang, Bor Jang; Choi, Jang Hyun, et al	ARTICLE	1068	N-Acetylfarnesylcysteine Is a Novel Class of Peroxisome Proliferator-activated Receptor gamma Ligand with Partial and Full Agonist Activity in Vitro and in Vivo
2011-09	Antidiabetic actions of a non-agonist PPAR gamma ligand blocking Cdk5-mediated phosphorylation	Choi, Jang Hyun; Banks, Alexander S.; Kamenecka, Theodore M., et al	ARTICLE	1188	Antidiabetic actions of a non-agonist PPAR gamma ligand blocking Cdk5-mediated phosphorylation
2011-06	Separation of the gluconeogenic and mitochondrial functions of PGC-1 alpha through S6 kinase	Lustig, Yaniv; Ruas, Jorge L.; Estall, Jennifer L., et al	ARTICLE	1024	Separation of the gluconeogenic and mitochondrial functions of PGC-1 alpha through S6 kinase
2011-02	The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1 alpha/ATF6 alpha Complex	Wu, Jun; Ruas, Jorge L.; Estall, Jennifer L., et al	ARTICLE	1085	The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1 alpha/ATF6 alpha Complex
2010-07	Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5	Choi, Jang Hyun; Banks, Alexander S.; Estall, Jennifer L., et al	ARTICLE	1215	Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5
2008-09	Potential Inhibition of PDK1/Akt Signaling by Phenothiazines Suppresses Cancer Cell Proliferation and Survival	Choi, Jang Hyun; Yang, Yong Ryoul; Lee, Seul Ki, et al	ARTICLE	1124	Potential Inhibition of PDK1/Akt Signaling by Phenothiazines Suppresses Cancer Cell Proliferation and Survival
2008-01	Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis	Mian, Md. Firoz; Kang, Changkeun; Lee, Seunghwan, et al	ARTICLE	1265	Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis
2008-01	Phospholipase C-epsilon augments epidermal growth factor-dependent cell growth by inhibiting epidermal growth factor receptor down-regulation	Yun, Sanguk; Hong, Won-Pyo; Choi, Jang Hyun, et al	ARTICLE	1074	Phospholipase C-epsilon augments epidermal growth factor-dependent cell growth by inhibiting epidermal growth factor receptor down-regulation
2007-11	HVEM signaling in monocytes is mediated by intracellular calcium mobilization	Heo, Sook-Kyoung; Yoon, Min-A; Lee, Sang-Chul, et al	ARTICLE	1013
2007-08	Phospholipase C-gamma 1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activation	Choi, Jang Hyun; Yang, Yong-Ryoul; Lee, Seul Ki, et al	ARTICLE	1101	Phospholipase C-gamma 1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activation
2007-04	In vitro assay of neurofilament light chain self-assembly using truncated mutants	Kim, Sung-Kuk; Cho, Sang-Min; Lee, In-Bum, et al	ARTICLE	1102	In vitro assay of neurofilament light chain self-assembly using truncated mutants
2007	On/Off-regulation of phospholipase C-gamma 1-mediated signal transduction	Choi, Jang Hyun; Ryu, Sung Ho; Suh, Pann-Ghill	ARTICLE	1135	On/Off-regulation of phospholipase C-gamma 1-mediated signal transduction
2006-12	Phospholipase C gamma 1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B	Choi, Jang Hyun; Kim, Hyeon Soo; Kim, Sun-Hee, et al	ARTICLE	1266	Phospholipase C gamma 1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B
2006-10	Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid	Kim, Hyeon Soo; Song, Minseok; Yumkham, Sanatombi, et al	ARTICLE	1130	Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid
2006-09	Serotonin stimulates GnRH secretion through the c-Src-PLC gamma 1 pathway in GT1-7 hypothalamic cells	Kim, Hyeon Soo; Yumkham, Sanatombi; Choi, Jang Hyun, et al	ARTICLE	1015	Serotonin stimulates GnRH secretion through the c-Src-PLC gamma 1 pathway in GT1-7 hypothalamic cells

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