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Choi, Jang Hyun (최장현)

Department
Department of Biological Sciences(생명과학과)
Website
https://ldmunist.wixsite.com/choilab
Lab
Lab of Diabetes and Metabolism Lab. (당뇨 및 대사질환 연구실)
Research Keywords
당뇨, 대사질환, 유전자조절, Diabetes, Metabolic Disorders, Gene Regulation, PPARg
Research Interests
Obesity is a major risk factor for metabolic diseases such as type 2 diabetes, dyslipidemia, cardiovascular disease and cancers. The number of patients with metabolic diseases rapidly increasing and is reaching the levels of infectious diseases.Our lab is interested in understanding the molecular pathways that link adipose tissue biology to this staggering array of pathologies such as diabetes and metabolic diseases. These studies can be the scientific basis for developing novel anti-diabetic agents.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2011-02The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1 alpha/ATF6 alpha ComplexWu, Jun; Ruas, Jorge L.; Estall, Jennifer L., et alARTICLE660 The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1 alpha/ATF6 alpha Complex
2010-07Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5Choi, Jang Hyun; Banks, Alexander S.; Estall, Jennifer L., et alARTICLE745 Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR gamma by Cdk5
2008-09Potential Inhibition of PDK1/Akt Signaling by Phenothiazines Suppresses Cancer Cell Proliferation and SurvivalChoi, Jang Hyun; Yang, Yong Ryoul; Lee, Seul Ki, et alARTICLE695 Potential Inhibition of PDK1/Akt Signaling by Phenothiazines Suppresses Cancer Cell Proliferation and Survival
2008-01Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosisMian, Md. Firoz; Kang, Changkeun; Lee, Seunghwan, et alARTICLE753 Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis
2008-01Phospholipase C-epsilon augments epidermal growth factor-dependent cell growth by inhibiting epidermal growth factor receptor down-regulationYun, Sanguk; Hong, Won-Pyo; Choi, Jang Hyun, et alARTICLE694 Phospholipase C-epsilon augments epidermal growth factor-dependent cell growth by inhibiting epidermal growth factor receptor down-regulation
2007-11HVEM signaling in monocytes is mediated by intracellular calcium mobilizationHeo, Sook-Kyoung; Yoon, Min-A; Lee, Sang-Chul, et alARTICLE686
2007-08Phospholipase C-gamma 1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activationChoi, Jang Hyun; Yang, Yong-Ryoul; Lee, Seul Ki, et alARTICLE728 Phospholipase C-gamma 1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activation
2007-04In vitro assay of neurofilament light chain self-assembly using truncated mutantsKim, Sung-Kuk; Cho, Sang-Min; Lee, In-Bum, et alARTICLE651 In vitro assay of neurofilament light chain self-assembly using truncated mutants
2007On/Off-regulation of phospholipase C-gamma 1-mediated signal transductionChoi, Jang Hyun; Ryu, Sung Ho; Suh, Pann-GhillARTICLE695 On/Off-regulation of phospholipase C-gamma 1-mediated signal transduction
2006-12Phospholipase C gamma 1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1BChoi, Jang Hyun; Kim, Hyeon Soo; Kim, Sun-Hee, et alARTICLE798 Phospholipase C gamma 1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B
2006-10Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acidKim, Hyeon Soo; Song, Minseok; Yumkham, Sanatombi, et alARTICLE730 Identification of a new functional target of haloperidol metabolite: implications for a receptor-independent role of 3-(4-fluorobenzoyl) propionic acid
2006-09Serotonin stimulates GnRH secretion through the c-Src-PLC gamma 1 pathway in GT1-7 hypothalamic cellsKim, Hyeon Soo; Yumkham, Sanatombi; Choi, Jang Hyun, et alARTICLE641 Serotonin stimulates GnRH secretion through the c-Src-PLC gamma 1 pathway in GT1-7 hypothalamic cells
2006-08Haloperidol induces calcium ion influx via L-type calcium channels in hippocampal HN33 cells and renders the neurons more susceptible to oxidative stressKim, Hyeon Soo; Yumkham, Sanatombi; Choi, Jang Hyun, et alARTICLE774
2006-06Pleckstrin homology domain of phospholipase C-gamma 1 directly binds to 68-kDa neurofilament light chainKim, Sung-Kuk; Choi, Jang Hyun; Suh, Pann-Ghill, et alARTICLE657
2006-06Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264.7 cells during costimulation with LPS and IFN gammaKim, HS; YumkhaM, S; Choi, Jang Hyun, et alARTICLE655 Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage Raw264.7 cells during costimulation with LPS and IFN gamma
2005-10Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma 1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma 1Choi, Jang Hyun; Hong, WP; Yun, S, et alARTICLE785 Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma 1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma 1
2005-02Pleckstrin homology domains of phospholipase C-gamma 1 directly interact with beta-tubulin for activation of phospholipase C-gamma 1 and reciprocal modulation of beta-tubulin function in microtubule assemblyChang, JS; Kim, SK; Kwon, TK, et alARTICLE693 Pleckstrin homology domains of phospholipase C-gamma 1 directly interact with beta-tubulin for activation of phospholipase C-gamma 1 and reciprocal modulation of beta-tubulin function in microtubule assembly
2004-08Phospholipase C-gamma 1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosisChoi, Jang Hyun; Park, JB; Bae, SS, et alARTICLE716 Phospholipase C-gamma 1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis
2004-08Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domainChoi, Jang Hyun; Hong, WP; Kim, MJ, et alARTICLE759 Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain
2003-04Cbl competitively inhibits epidermal growth factor-induced activation of phospholipase C-gamma 1Choi, Jang Hyun; Bae, SS; Park, JB, et alARTICLE650

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