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Choi, Jang Hyun (최장현)

Department
Department of Biological Sciences(생명과학과)
Website
https://ldmunist.wixsite.com/choilab
Lab
Lab of Diabetes and Metabolism Lab. (당뇨 및 대사질환 연구실)
Research Keywords
당뇨, 대사질환, 유전자조절, Diabetes, Metabolic Disorders, Gene Regulation, PPARg
Research Interests
Obesity is a major risk factor for metabolic diseases such as type 2 diabetes, dyslipidemia, cardiovascular disease and cancers. The number of patients with metabolic diseases rapidly increasing and is reaching the levels of infectious diseases.Our lab is interested in understanding the molecular pathways that link adipose tissue biology to this staggering array of pathologies such as diabetes and metabolic diseases. These studies can be the scientific basis for developing novel anti-diabetic agents.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2015-03Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRαChoi, Jin Sil; Choi, Sun-Sil; Kim, Eun Sun, et alARTICLE1135 Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα
2014-11Thrap3 docks on phosphoserine 273 of PPAR gamma and controls diabetic gene programmingChoi, Jang Hyun; Choi, Sun-Sil; Kim, Eun Sun, et alARTICLE905 Thrap3 docks on phosphoserine 273 of PPAR gamma and controls diabetic gene programming
2014-11Revisiting PPAR gamma as a target for the treatment of metabolic disordersChoi, Jang Hyun; Park, Jiyoung; Choi, Sun-SilARTICLE1058 Revisiting PPAR gamma as a target for the treatment of metabolic disorders
2014-09A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivityChoi, Sun-Sil; Kim, Eun Sun; Koh, Minseob, et alARTICLE958 A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity
2014-07OGA heterozygosity suppresses intestinal tumorigenesis in Apc min/+ miceYang, Yongryoul; Jang H.J.; Yoon, Sunyoung, et alARTICLE1085 OGA heterozygosity suppresses intestinal tumorigenesis in Apc min/+ mice
2014-05Phenotypic screening to identify small-molecule enhancers for glucose uptake: Target identification and rational optimization of their efficacyKoh, Minseob; Park, Jongmin; Koo, Ja Young, et alARTICLE850 Phenotypic screening to identify small-molecule enhancers for glucose uptake: Target identification and rational optimization of their efficacy
2013-04C1-Ten Is a Protein Tyrosine Phosphatase of Insulin Receptor Substrate 1 (IRS-1), Regulating IRS-1 Stability and Muscle AtrophyKoh, Ara; Lee, Mi Nam; Yang, Yong Ryoul, et alARTICLE947 C1-Ten Is a Protein Tyrosine Phosphatase of Insulin Receptor Substrate 1 (IRS-1), Regulating IRS-1 Stability and Muscle Atrophy
2013-01Phospholipase C-gamma 1 involved in brain disordersJang, Hyun-Jun; Yang, Yong Ryoul; Kim, Jung Kuk, et alARTICLE859 Phospholipase C-gamma 1 involved in brain disorders
2012-11B-cell translocation gene-2 increases hepatic gluconeogenesis via induction of CREBHwang, Seung-Lark; Kwon, Okyun; Lee, Soo Jin, et alARTICLE1113 B-cell translocation gene-2 increases hepatic gluconeogenesis via induction of CREB
2012-08Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exerciseMoon, Hyo Youl; Kim, Se Hyun; Yang, Yong Ryoul, et alARTICLE868 Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise
2012-07Beige adipocytes are a distinct type of thermogenic fat cell in mouse and humanWu, Jun; Bostrom, Pontus; Sparks, Lauren M., et alARTICLE1013 Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
2012-06PDZ Domain-containing 1 (PDZK1) Protein Regulates Phospholipase C-beta 3 (PLC-beta 3)-specific Activation of Somatostatin by Forming a Ternary Complex with PLC-beta 3 and Somatostatin ReceptorsKim, Jung Kuk; Kwon, Ohman; Kim, Jinho, et alARTICLE997 PDZ Domain-containing 1 (PDZK1) Protein Regulates Phospholipase C-beta 3 (PLC-beta 3)-specific Activation of Somatostatin by Forming a Ternary Complex with PLC-beta 3 and Somatostatin Receptors
2012-06O-GlcNAcase is essential for embryonic development and maintenance of genomic stabilityYang, Yong Ryoul; Song, Minseok; Lee, Ho, et alARTICLE752 O-GlcNAcase is essential for embryonic development and maintenance of genomic stability
2012-02Fibroblast Growth Factor-21 Regulates PPAR gamma Activity and the Antidiabetic Actions of ThiazolidinedionesDutchak, Paul A.; Katafuchi, Takeshi; Bookout, Angie L., et alARTICLE691 Fibroblast Growth Factor-21 Regulates PPAR gamma Activity and the Antidiabetic Actions of Thiazolidinediones
2012-01Diverse cellular and physiological roles of phospholipase C-γ1Yang, Yong Ryoul; Choi, Jang Hyun; Chang, Jong-Soo, et alARTICLE836 Diverse cellular and physiological roles of phospholipase C-γ1
2012-01Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated ReceptorsMalapaka, Raghu R. V.; Khoo, SokKean; Zhang, Jifeng, et alARTICLE697 Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors
2012-01A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesisBostroem, Pontus; Wu, Jun; Jedrychowski, Mark P., et alARTICLE844 A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
2011-12N-Acetylfarnesylcysteine Is a Novel Class of Peroxisome Proliferator-activated Receptor gamma Ligand with Partial and Full Agonist Activity in Vitro and in VivoBhalla, Kavita; Hwang, Bor Jang; Choi, Jang Hyun, et alARTICLE688 N-Acetylfarnesylcysteine Is a Novel Class of Peroxisome Proliferator-activated Receptor gamma Ligand with Partial and Full Agonist Activity in Vitro and in Vivo
2011-09Antidiabetic actions of a non-agonist PPAR gamma ligand blocking Cdk5-mediated phosphorylationChoi, Jang Hyun; Banks, Alexander S.; Kamenecka, Theodore M., et alARTICLE692 Antidiabetic actions of a non-agonist PPAR gamma ligand blocking Cdk5-mediated phosphorylation
2011-06Separation of the gluconeogenic and mitochondrial functions of PGC-1 alpha through S6 kinaseLustig, Yaniv; Ruas, Jorge L.; Estall, Jennifer L., et alARTICLE681 Separation of the gluconeogenic and mitochondrial functions of PGC-1 alpha through S6 kinase

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