사진

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Choi, Jang Hyun (최장현)

Department
Department of Biological Sciences(생명과학과)
Website
https://ldmunist.wixsite.com/choilab
Lab
Lab of Diabetes and Metabolism Lab. (당뇨 및 대사질환 연구실)
Research Keywords
당뇨, 대사질환, 유전자조절, Diabetes, Metabolic Disorders, Gene Regulation, PPARg
Research Interests
Obesity is a major risk factor for metabolic diseases such as type 2 diabetes, dyslipidemia, cardiovascular disease and cancers. The number of patients with metabolic diseases rapidly increasing and is reaching the levels of infectious diseases.Our lab is interested in understanding the molecular pathways that link adipose tissue biology to this staggering array of pathologies such as diabetes and metabolic diseases. These studies can be the scientific basis for developing novel anti-diabetic agents.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2022-03Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9Kwon, Taejoon; Ra, Jae Sun; Lee, Soyoung, et alARTICLE341 Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9
2021-12Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARALee, Yo Han; Jang, Hyun-Jun; Kim, Sounkou, et alARTICLE161 Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA
2021-10Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic beta-cells and improves insulin sensitivity in diabetic miceHyun, Jimin; Park, Mi Hyeon; Lee, Yo Han, et alARTICLE269 Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic beta-cells and improves insulin sensitivity in diabetic mice
2021-10Thrap3 promotes R-loop resolution via interaction with methylated DDX5Kang, Hyun Je; Eom, Hye-jin; Kim, Hongtae, et alARTICLE470 Thrap3 promotes R-loop resolution via interaction with methylated DDX5
2021-06NSMF promotes the replication stress-induced DNA damage response for genome maintenanceJu, Min Kyung; Shin, Kyeong Jin; Lee, Joo Rak, et alARTICLE387 NSMF promotes the replication stress-induced DNA damage response for genome maintenance
2020-09Phospholipase Cγ의 생리적 기능과 질병과 연관된 돌연변이장현준; 최장현; 장종수ARTICLE99 Phospholipase Cγ의 생리적 기능과 질병과 연관된 돌연변이
2020-06Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasisChoi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et alARTICLE525 Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-03Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK ActivationLee, Jae Min; Choi, Sun Sil; Park, Mi Hyeon, et alARTICLE435 Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
2020-02PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273Khim, Keon Woo; Choi, Sun Sil; Jang, Hyun-Jun, et alARTICLE452 PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273
2020-01Glucosylceramide synthase regulates adipo‐osteogenic differentiation through synergistic activation of PPARγ with GlcCerJang, Hyun-Jun; Lim, Seyoung; Kim, Jung-Min, et alARTICLE573 Glucosylceramide synthase regulates adipo‐osteogenic differentiation through synergistic activation of PPARγ with GlcCer
2019-10Phospholipase C-β1 potentiates glucose-stimulated insulin secretionHwang, Hyeon-Jeong; Yang, Yong Ryoul; Kim, Hye Yun, et alARTICLE607 Phospholipase C-β1 potentiates glucose-stimulated insulin secretion
2019-09Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylationKim, Hyunsoo; Jo, Ala; Choi, Sun-sil, et alARTICLE466 Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylation
2019-03Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppressionHua, Tuyen N.M.; Kim, Min-Kyu; Vo, Vu T.A., et alARTICLE404 Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression
2019-01COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver diseaseLee, Changu; Kim, Min; Lee, Jun Ho, et alARTICLE885 COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease
2018-10The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gammaLee, Jae Min; Choi, Sun Sil; Lee, Yo Han, et alARTICLE759 The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gamma
2018-09RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2Shin, Yoonjae; Kim, Yong Woo; Kim, Hyemin, et alARTICLE654 RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2
2018-06Flightless-I Controls Fat Storage in DrosophilaPark, Jung-Eun; Lee, Eun Ji; Kim, Jung Kwan, et alARTICLE719 Flightless-I Controls Fat Storage in Drosophila
2018-05Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channelsHwang, Hyeon-Jeong; Park, Kyoung-Su; Choi, Jang Hyun, et alARTICLE852 Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channels
2018-01Noncanonical agonist PPAR gamma ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapyKhandekar, Melin J.; Banks, Alexander S.; Laznik-Bogoslavski, Dina, et alARTICLE705 Noncanonical agonist PPAR gamma ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy
2017-10Forebrain-specific ablation of phospholipase C gamma 1 causes manic-like behaviorYang, YR; Jung, JH; Kim, SJ, et alARTICLE1065 Forebrain-specific ablation of phospholipase C gamma 1 causes manic-like behavior

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