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Choi, Jang Hyun (최장현)

Department: School of Life Sciences(생명과학부)

Website: https://ldmunist.wixsite.com/choilab

Lab: Lab of Diabetes and Metabolism Lab. (당뇨 및 대사질환 연구실)

Research Keywords: 당뇨, 대사질환, 유전자조절, Diabetes, Metabolic Disorders, Gene Regulation, PPARg

Research Interests: Obesity is a major risk factor for metabolic diseases such as type 2 diabetes, dyslipidemia, cardiovascular disease and cancers. The number of patients with metabolic diseases rapidly increasing and is reaching the levels of infectious diseases.Our lab is interested in understanding the molecular pathways that link adipose tissue biology to this staggering array of pathologies such as diabetes and metabolic diseases. These studies can be the scientific basis for developing novel anti-diabetic agents.

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Issue Date	Title	Author(s)	Type	View	Altmetrics
2020-06	Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis	Choi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et al	ARTICLE	105	Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-03	Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation	Lee, Jae Min; Choi, Sun Sil; Park, Mi Hyeon, et al	ARTICLE	128	Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
2020-02	PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273	Khim, Keon Woo; Choi, Sun Sil; Jang, Hyun-Jun, et al	ARTICLE	154	PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273
2020-01	Glucosylceramide synthase regulates adipo-osteogenic differentiation through synergistic activation of PPARγ with GlcCer	Jang, Hyun-Jun; Lim, Seyoung; Kim, Jung-Min, et al	ARTICLE	216	Glucosylceramide synthase regulates adipo-osteogenic differentiation through synergistic activation of PPARγ with GlcCer
2019-10	Phospholipase C-β1 potentiates glucose-stimulated insulin secretion	Hwang, Hyeon-Jeong; Yang, Yong Ryoul; Kim, Hye Yun, et al	ARTICLE	276	Phospholipase C-β1 potentiates glucose-stimulated insulin secretion
2019-09	Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylation	Kim, Hyunsoo; Jo, Ala; Choi, Sun-sil, et al	ARTICLE	265	Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylation
2019-03	Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression	Hua, Tuyen N.M.; Kim, Min-Kyu; Vo, Vu T.A., et al	ARTICLE	186	Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression
2019-01	COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease	Lee, Changu; Kim, Min; Lee, Jun Ho, et al	ARTICLE	515	COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease
2018-10	The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gamma	Lee, Jae Min; Choi, Sun Sil; Lee, Yo Han, et al	ARTICLE	485	The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gamma
2018-09	RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2	Shin, Yoonjae; Kim, Yong Woo; Kim, Hyemin, et al	ARTICLE	377	RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2
2018-06	Flightless-I Controls Fat Storage in Drosophila	Park, Jung-Eun; Lee, Eun Ji; Kim, Jung Kwan, et al	ARTICLE	443	Flightless-I Controls Fat Storage in Drosophila
2018-05	Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channels	Hwang, Hyeon-Jeong; Park, Kyoung-Su; Choi, Jang Hyun, et al	ARTICLE	525	Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channels
2018-01	Noncanonical agonist PPAR gamma ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy	Khandekar, Melin J.; Banks, Alexander S.; Laznik-Bogoslavski, Dina, et al	ARTICLE	429	Noncanonical agonist PPAR gamma ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy
2017-10	Forebrain-specific ablation of phospholipase C gamma 1 causes manic-like behavior	Yang, YR; Jung, JH; Kim, SJ, et al	ARTICLE	738	Forebrain-specific ablation of phospholipase C gamma 1 causes manic-like behavior
2016-08	Mechanistic Elucidation Guided by Covalent Inhibitors for the Development of Anti-diabetic PPARγ Ligands	Bae, Hwan; Jang, Jun Young; Choi, Sun-Sil, et al	ARTICLE	961	Mechanistic Elucidation Guided by Covalent Inhibitors for the Development of Anti-diabetic PPARγ Ligands
2016-04	PPAR gamma Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue	Choi, Sun-sil; Kim, Eun-Sun; Jung, Ji-Eun, et al	ARTICLE	1223	PPAR gamma Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue
2015-12	Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity	Choi, Sunsil; Jung, Ji-Eun; Yang, Yong Ryoul, et al	ARTICLE	908	Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity
2015-12	Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice.	Yang, Yong Ryoul; Jang, Hyun-Jun; Choi, Sun-Sil, et al	ARTICLE	829	Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice.
2015-05	Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling	Yang, Yong Ryoul; Kim, Dae Hyun; Seo, Young-Kyo, et al	ARTICLE	1022	Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling
2015-03	Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα	Choi, Jin Sil; Choi, Sun-Sil; Kim, Eun Sun, et al	ARTICLE	1028	Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα

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