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Choi, Jang Hyun (최장현)

Department: Department of Biological Sciences(생명과학과)

Website: https://ldmunist.wixsite.com/choilab

Lab: Lab of Diabetes and Metabolism Lab. (당뇨 및 대사질환 연구실)

Research Keywords: 당뇨, 대사질환, 유전자조절, Diabetes, Metabolic Disorders, Gene Regulation, PPARg

Research Interests: Obesity is a major risk factor for metabolic diseases such as type 2 diabetes, dyslipidemia, cardiovascular disease and cancers. The number of patients with metabolic diseases rapidly increasing and is reaching the levels of infectious diseases.Our lab is interested in understanding the molecular pathways that link adipose tissue biology to this staggering array of pathologies such as diabetes and metabolic diseases. These studies can be the scientific basis for developing novel anti-diabetic agents.

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Issue Date	Title	Author(s)	Type	View	Altmetrics
2023-09	Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors	Wie, Minwoo; Khim, Keon Woo; Groehler Iv, Arnold S, et al	ARTICLE	397	Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors
2023-08	Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase	Kang, Yujin; Han, Ye Gi; Khim, Keon Woo, et al	ARTICLE	826	Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase
2023-08	Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy	Jang, Hyun-Jun; Lee, Yo Han; Tam, Dao, et al	ARTICLE	1077	Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy
2022-03	Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9	Kwon, Taejoon; Ra, Jae Sun; Lee, Soyoung, et al	ARTICLE	1017	Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9
2021-12	Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA	Lee, Yo Han; Jang, Hyun-Jun; Kim, Sounkou, et al	ARTICLE	670	Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA
2021-10	Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic beta-cells and improves insulin sensitivity in diabetic mice	Hyun, Jimin; Park, Mi Hyeon; Lee, Yo Han, et al	ARTICLE	689	Vernicia fordii (Hemsl.) Airy Shaw extract stimulates insulin secretion in pancreatic beta-cells and improves insulin sensitivity in diabetic mice
2021-10	Thrap3 promotes R-loop resolution via interaction with methylated DDX5	Kang, Hyun Je; Eom, Hye-jin; Kim, Hongtae, et al	ARTICLE	1098	Thrap3 promotes R-loop resolution via interaction with methylated DDX5
2021-06	NSMF promotes the replication stress-induced DNA damage response for genome maintenance	Ju, Min Kyung; Shin, Kyeong Jin; Lee, Joo Rak, et al	ARTICLE	797	NSMF promotes the replication stress-induced DNA damage response for genome maintenance
2020-09	Phospholipase Cγ의 생리적 기능과 질병과 연관된 돌연변이	장현준; 최장현; 장종수	ARTICLE	375	Phospholipase Cγ의 생리적 기능과 질병과 연관된 돌연변이
2020-06	Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis	Choi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et al	ARTICLE	953	Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-03	Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation	Lee, Jae Min; Choi, Sun Sil; Park, Mi Hyeon, et al	ARTICLE	792	Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
2020-02	PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273	Khim, Keon Woo; Choi, Sun Sil; Jang, Hyun-Jun, et al	ARTICLE	831	PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273
2020-01	Glucosylceramide synthase regulates adipo‐osteogenic differentiation through synergistic activation of PPARγ with GlcCer	Jang, Hyun-Jun; Lim, Seyoung; Kim, Jung-Min, et al	ARTICLE	1012	Glucosylceramide synthase regulates adipo‐osteogenic differentiation through synergistic activation of PPARγ with GlcCer
2019-10	Phospholipase C-β1 potentiates glucose-stimulated insulin secretion	Hwang, Hyeon-Jeong; Yang, Yong Ryoul; Kim, Hye Yun, et al	ARTICLE	936	Phospholipase C-β1 potentiates glucose-stimulated insulin secretion
2019-09	Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylation	Kim, Hyunsoo; Jo, Ala; Choi, Sun-sil, et al	ARTICLE	747	Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylation
2019-03	Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression	Hua, Tuyen N.M.; Kim, Min-Kyu; Vo, Vu T.A., et al	ARTICLE	747	Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression
2019-01	COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease	Lee, Changu; Kim, Min; Lee, Jun Ho, et al	ARTICLE	1242	COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease
2018-10	The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gamma	Lee, Jae Min; Choi, Sun Sil; Lee, Yo Han, et al	ARTICLE	1128	The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gamma
2018-09	RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2	Shin, Yoonjae; Kim, Yong Woo; Kim, Hyemin, et al	ARTICLE	1053	RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2
2018-06	Flightless-I Controls Fat Storage in Drosophila	Park, Jung-Eun; Lee, Eun Ji; Kim, Jung Kwan, et al	ARTICLE	1097	Flightless-I Controls Fat Storage in Drosophila

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