사진

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Choi, Jang Hyun (최장현)

Department
School of Life Sciences(생명과학부)
Website
https://ldmunist.wixsite.com/choilab
Lab
Lab of Diabetes and Metabolism Lab. (당뇨 및 대사질환 연구실)
Research Keywords
당뇨, 대사질환, 유전자조절, Diabetes, Metabolic Disorders, Gene Regulation, PPARg
Research Interests
Obesity is a major risk factor for metabolic diseases such as type 2 diabetes, dyslipidemia, cardiovascular disease and cancers. The number of patients with metabolic diseases rapidly increasing and is reaching the levels of infectious diseases.Our lab is interested in understanding the molecular pathways that link adipose tissue biology to this staggering array of pathologies such as diabetes and metabolic diseases. These studies can be the scientific basis for developing novel anti-diabetic agents.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2020-06Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasisChoi, Sun Sil; Lee, Sang Kwon; Kim, Joong Kwan, et alARTICLE105 Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
2020-03Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK ActivationLee, Jae Min; Choi, Sun Sil; Park, Mi Hyeon, et alARTICLE128 Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
2020-02PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273Khim, Keon Woo; Choi, Sun Sil; Jang, Hyun-Jun, et alARTICLE154 PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273
2020-01Glucosylceramide synthase regulates adipo-osteogenic differentiation through synergistic activation of PPARγ with GlcCerJang, Hyun-Jun; Lim, Seyoung; Kim, Jung-Min, et alARTICLE216 Glucosylceramide synthase regulates adipo-osteogenic differentiation through synergistic activation of PPARγ with GlcCer
2019-10Phospholipase C-β1 potentiates glucose-stimulated insulin secretionHwang, Hyeon-Jeong; Yang, Yong Ryoul; Kim, Hye Yun, et alARTICLE276 Phospholipase C-β1 potentiates glucose-stimulated insulin secretion
2019-09Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylationKim, Hyunsoo; Jo, Ala; Choi, Sun-sil, et alARTICLE265 Rational design and synthesis of reversible covalent PPARγ antagonistic ligands inhibiting Ser273 phosphorylation
2019-03Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppressionHua, Tuyen N.M.; Kim, Min-Kyu; Vo, Vu T.A., et alARTICLE186 Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression
2019-01COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver diseaseLee, Changu; Kim, Min; Lee, Jun Ho, et alARTICLE515 COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease
2018-10The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gammaLee, Jae Min; Choi, Sun Sil; Lee, Yo Han, et alARTICLE485 The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasomemediated degradation of PPAR gamma
2018-09RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2Shin, Yoonjae; Kim, Yong Woo; Kim, Hyemin, et alARTICLE377 RASAL3 preferentially stimulates GTP hydrolysis of the Rho family small GTPase Rac2
2018-06Flightless-I Controls Fat Storage in DrosophilaPark, Jung-Eun; Lee, Eun Ji; Kim, Jung Kwan, et alARTICLE443 Flightless-I Controls Fat Storage in Drosophila
2018-05Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channelsHwang, Hyeon-Jeong; Park, Kyoung-Su; Choi, Jang Hyun, et alARTICLE525 Zafirlukast promotes insulin secretion by increasing calcium influx through L-type calcium channels
2018-01Noncanonical agonist PPAR gamma ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapyKhandekar, Melin J.; Banks, Alexander S.; Laznik-Bogoslavski, Dina, et alARTICLE429 Noncanonical agonist PPAR gamma ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy
2017-10Forebrain-specific ablation of phospholipase C gamma 1 causes manic-like behaviorYang, YR; Jung, JH; Kim, SJ, et alARTICLE738 Forebrain-specific ablation of phospholipase C gamma 1 causes manic-like behavior
2016-08Mechanistic Elucidation Guided by Covalent Inhibitors for the Development of Anti-diabetic PPARγ LigandsBae, Hwan; Jang, Jun Young; Choi, Sun-Sil, et alARTICLE961 Mechanistic Elucidation Guided by Covalent Inhibitors for the Development of Anti-diabetic PPARγ Ligands
2016-04PPAR gamma Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose TissueChoi, Sun-sil; Kim, Eun-Sun; Jung, Ji-Eun, et alARTICLE1223 PPAR gamma Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue
2015-12Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivityChoi, Sunsil; Jung, Ji-Eun; Yang, Yong Ryoul, et alARTICLE908 Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity
2015-12Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice.Yang, Yong Ryoul; Jang, Hyun-Jun; Choi, Sun-Sil, et alARTICLE829 Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga +/- mice.
2015-05Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signalingYang, Yong Ryoul; Kim, Dae Hyun; Seo, Young-Kyo, et alARTICLE1022 Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling
2015-03Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRαChoi, Jin Sil; Choi, Sun-Sil; Kim, Eun Sun, et alARTICLE1028 Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα

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