사진

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Kwon, Hyug Moo (권혁무)

Department
Department of Biological Sciences(생명과학과)
Website
http://ikd.unist.ac.kr/
Lab
Immunometabolism and Cancer Lab. (면역대사와 암 실험실)
Research Keywords
만성염증질환, 뇌질환, 신장질환, 비만, 암, 유전체 불안정성, 대사 증후군, Chronic inflammatory diseases, Brain disorder, Kidney disorder, Obesity, Cancer, TonEBP, Genomic instability, Metabolic syndrome
Research Interests
Emerging data revealed the critical role of the TonEBP (NFAT5), initially identified as a central DNA binding transcription factors, in inflammatory diseases including rheumatoid arthritis, atherosclerosis, and chronic kidney disease. We suggested that TonEBP is a critical factor in diet-induced obesity, cancer, brain disorders and autoimmune disease. Our research group investigates cellular and molecular pathway of TonEBP action in a variety of inflammatory diseases and develops anti-inflammatory agents targeting TonEBP.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2021-08PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damageYe, Byeong Jin; Kang, Hyun Je; Lee-Kwon, Whaseon, et alARTICLE214 PARP1-mediated PARylation of TonEBP prevents R-loop-associated DNA damage
2021-01TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolutionKang, Hyun Je; Cheon, Na Young; Park, Hyun, et alARTICLE221 TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution
2020-12Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-kappa B and AP-1Jeong, Gyu Won; Lee, Hwan Hee; Lee-Kwon, Whaseon, et alARTICLE191 Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-kappa B and AP-1
2020-09TonEBP Promotes beta-Cell Survival under ER Stress by Enhancing AutophagyKang, Hyun Je; Yoo, Eun Jin; Lee, Hwan Hee, et alARTICLE193 TonEBP Promotes beta-Cell Survival under ER Stress by Enhancing Autophagy
2020-08Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistanceLee, Jun Ho; Suh, Jae Hee; Kang, Hyun Je, et alARTICLE169 Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistance
2020-06TonEBP in dendritic cells mediates pro-inflammatory maturation and Th1/Th17 responsesYe, Byeong Jin; Lee, Hwan Hee; Yoo, Eun Jin, et alARTICLE234 TonEBP in dendritic cells mediates pro-inflammatory maturation and Th1/Th17 responses
2020-06The evolving role of TonEBP as an immunometabolic stress proteinChoi, Soo Youn; Lee-Kwon, Whaseon; Kwon, Hyug MooARTICLE135 The evolving role of TonEBP as an immunometabolic stress protein
2019-10Tonicity-responsive enhancer binding protein (TonEBP) regulates TNF-alpha-induced hypothalamic inflammationKim, Han Rae; Kim, Dong Hee; Kim, Kwang Kon, et alARTICLE260 Tonicity-responsive enhancer binding protein (TonEBP) regulates TNF-alpha-induced hypothalamic inflammation
2019-10Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney InjuryYoo, Eun Jin; Lim, Sun Woo; Kang, Hyun Je, et alARTICLE345 Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury
2019-09TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1Kang, Hyun Je; Park, Hyun; Yoo, Eun Jin, et alARTICLE341 TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1
2019-08TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beigingLee, Hwan Hee; An, Seung Min; Ye, Byeong Jin, et alARTICLE397 TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging
2019-04TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its PromoterYoo, Eun Jin; Lee, Hwan Hee; Ye, Byeong Jin, et alARTICLE290 TonEBP Suppresses the HO-1 Gene by Blocking Recruitment of Nrf2 to Its Promoter
2019-02Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasisLee, Jun Ho; Suh, Jae Hee; Choi, Soo Youn, et alARTICLE589 Tonicity-responsive enhancer-binding protein promotes hepatocellular carcinogenesis, recurrence and metastasis
2019-01COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver diseaseLee, Changu; Kim, Min; Lee, Jun Ho, et alARTICLE707 COL6A3-derived endotrophin links reciprocal interactions among hepatic cells in the pathology of chronic liver disease
2018-07Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2Lee, Saseong; Kong, Jin-Sun; You, Sungyong, et alARTICLE331 Transcription Factor NFAT5 Promotes Migration and Invasion of Rheumatoid Synoviocytes via Coagulation Factor III and CCL2
2018-03Optical properties of acute kidney injury measured by quantitative phase imagingBan, Sungbea; Min, Eunjung; Baek, Songyee, et alARTICLE606 Optical properties of acute kidney injury measured by quantitative phase imaging
2018-02Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal InjuryChoi, Soo Youn; Lim, Sun Woo; Salimi, Shabnam, et alARTICLE770 Tonicity-Responsive Enhancer-Binding Protein Mediates Hyperglycemia-Induced Inflammation and Vascular and Renal Injury
2017-08TonEBP/NFAT5 haploinsufficiency attenuates hippocampal inflammation in high-fat diet/streptozotocin-induced diabetic miceLee, Jong Youl; Jeong, Eun Ae; Kim, Kyung Eun, et alARTICLE658 TonEBP/NFAT5 haploinsufficiency attenuates hippocampal inflammation in high-fat diet/streptozotocin-induced diabetic mice
2017-05Roles of fluid shear stress and retinoic acid in the differentiation of primary cultured human podocytesYang, Seung Hee; Choi, Jin Woo; Huh, Dongeun, et alARTICLE528 Roles of fluid shear stress and retinoic acid in the differentiation of primary cultured human podocytes
2017-04Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding InhibitorsHan, Eun-Jin; Kim, Hyun Young; Lee, Naeun, et alARTICLE814 Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors

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