사진

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Park, Cheol-Min (박철민)

Department
Department of Chemistry(화학과)
Website
https://sites.google.com/site/cmparklab/home
Lab
Synthetic and Medicinal Chemistry Lab. (유기합성 및 의약화학 연구실)
Research Keywords
유기합성, 유기화학, 의약화학, 촉매, Organic synthesis, medicinal chemistry, Catalysis
Research Interests
Organic molecules are found as key players in many fields from materials to medicine. Our research focuses on the development of new synthetic methods that facilitate the design and synthesis of bioactive compounds and chemical tools for pharmacological studies.
The access to compounds with unique and diverse structures enables us to explore their potential as novel therapeutic leads, chemical switches and probes. In this regard, organic synthesis forms the foundation of our approach. Heterocyclic compounds represent an important class of compounds that are found in numerous bioactive natural products, drugs, and molecular probes. We have been engaged in the field of heterocycle synthesis by developing new synthetic methods based on metal catalysis. Also, we are actively engaged in developing strategies and methods to generate novel structures and to evaluate their pharmacological intervention including cancer.
Another approach we are undertaking involves rational drug design where the discovery process begins with a hypothesis that the modulation of a target may have therapeutic value. To this end, extensive use of modern discovery tools such as parallel synthesis, computer-aided drug design, x-ray crystallography, and NMR allows us to rapidly identify potential lead compounds and further optimization.
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2012Rhodium(III)-Catalyzed Intramolecular Annulation through C?H Activation: Total Synthesis of (+/-)-Antofine, (+/-)-Septicine, (+/-)-Tylophorine, and RosettacinXu, Xianxiu; Liu, Yu; Park, Cheol-MinARTICLE681 Rhodium(III)-Catalyzed Intramolecular Annulation through C?H Activation: Total Synthesis of (+/-)-Antofine, (+/-)-Septicine, (+/-)-Tylophorine, and Rosettacin
2011-07Divergent reactivity of alpha-oximino carbenoids: facile access to 2-isoxazolines and 2H-azirinesQi, Xinxin; Jiang, Yaojia; Park, Cheol-MinARTICLE539 Divergent reactivity of alpha-oximino carbenoids: facile access to 2-isoxazolines and 2H-azirines
2011Stereoselective Synthesis of Highly Substituted Enamides by an Oxidative Heck ReactionLiu, Yu; Li, Dan; Park, Cheol-MinARTICLE704 Stereoselective Synthesis of Highly Substituted Enamides by an Oxidative Heck Reaction
2010-12N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitorsBruncko, Milan; Tahir, Stephen K.; Song, Xiaohong, et alARTICLE588 N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors
2010-11Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMRPetros, Andrew M.; Huth, Jeffrey R.; Oost, Thorsten, et alARTICLE571 Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR
2010-10Stereoselective Synthesis of alpha-Diazo Oxime Ethers and Their Application in the Synthesis of Highly Substituted Pyrroles through a [3+2] CycloadditionLourdusamy, Emmanuvel; Yao, Lin; Park, Cheol-MinARTICLE578 Stereoselective Synthesis of alpha-Diazo Oxime Ethers and Their Application in the Synthesis of Highly Substituted Pyrroles through a [3+2] Cycloaddition
2008-11Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 ProteinsPark, Cheol-Min; Bruncko, Milan; Adickes, Jessica, et alARTICLE645 Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins
2007-02Studies leading to potent, dual inhibitors of bcl-2 and Bcl-xLBruncko, Milan; Oost, Thorsten K.; Belli, Barbara A., et alARTICLE484 Studies leading to potent, dual inhibitors of bcl-2 and Bcl-xL
2006-12Design, synthesis, and computational studies of inhibitors of Bcl-X-LPark, Cheol-Min; Oie, Tetsuro; Petros, Andrew M., et alARTICLE464 Design, synthesis, and computational studies of inhibitors of Bcl-X-L
2006-01Concise synthesis of 3,7-dioxa-9-aza-bicyclo[3,3,1]-nonanePark, Cheol-MinARTICLE616 Concise synthesis of 3,7-dioxa-9-aza-bicyclo[3,3,1]-nonane
2005-02Non-peptidic small molecule inhibitors of XIAPPark, Cheol-Min; Sun, CH; Olejniczak, ET, et alARTICLE716 Non-peptidic small molecule inhibitors of XIAP
2005Inhibitors of anti-apoptotic proteins for cancer therapyElmore, SW; Oost, TK; Park, Cheol-MinARTICLE717 Inhibitors of anti-apoptotic proteins for cancer therapy
1999-06Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymesWender, PA; Lippa, B; Park, Cheol-Min, et alARTICLE502 Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes
1998-06The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1Wender, PA; DeBrabander, J; Harran, PG, et alARTICLE529 The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1
1998-05Synthesis of the first members of a new class of biologically active bryostatin analoguesWender, PA; De Brabander, J; Harran, PG, et alARTICLE540 Synthesis of the first members of a new class of biologically active bryostatin analogues
1998-03The chemistry-medicine continuum: Synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leadsWender, PA; Martin-Cantalejo, Y; Carpenter, AJ, et alARTICLE528 The chemistry-medicine continuum: Synthetic, computer, spectroscopic and biological studies on new chemotherapeutic leads
1995-08TOTAL SYNTHESIS OF DACTOMELYNESLEE, E; Park, Cheol-Min; YUN, JSARTICLE475 TOTAL SYNTHESIS OF DACTOMELYNES
1994-02C-FURANOSIDE SYNTHESIS VIA RADICAL CYCLIZATION OF BETA-ALKOXYACRYLATESLEE, E; Park, Cheol-MinARTICLE546 C-FURANOSIDE SYNTHESIS VIA RADICAL CYCLIZATION OF BETA-ALKOXYACRYLATES
1993-07BETA-ALKOXYACRYLATES IN RADICAL CYCLIZATIONS - REMARKABLY EFFICIENT OXACYCLE SYNTHESISLEE, E; TAE, JS; LEE, C, et alARTICLE586 BETA-ALKOXYACRYLATES IN RADICAL CYCLIZATIONS - REMARKABLY EFFICIENT OXACYCLE SYNTHESIS
1990SYNTHESIS OF ALPHA-METHYLENE-DELTA-VALEROLACTONES AND ALPHA-METHYLENECYCLOHEXANONES VIA RADICAL CYCLIZATION OF PROPIOLATES AND ACETYLENIC KETONESLEE, E; HUR, CU; Park, Cheol-MinARTICLE637 SYNTHESIS OF ALPHA-METHYLENE-DELTA-VALEROLACTONES AND ALPHA-METHYLENECYCLOHEXANONES VIA RADICAL CYCLIZATION OF PROPIOLATES AND ACETYLENIC KETONES

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