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Kang, Sebyung (강세병)

Department
Department of Biological Sciences(생명과학과)
Website
https://sites.google.com/site/proteinnanobio
Lab
Protein Nanobio Lab. (단백질 나노바이오 연구실)
Research Keywords
바이오 센서, 바이오 이미징, 나노바이오기술, 단백질 공학, 단백질 나노입자, 세포질내 단백질 전달, Nanobiotechnology, Protein Engineering, Protein Nanoparticle-based Drug Delivery, Biosensors, Bioimaging
Research Interests
Our researches focus on utilizing protein based nanobio-templates for  biomedical and biomaterial applications. To achieve these goals, we are using various types of nanobio-templates, such as viral capsids, small protein cages, and functional proteins, and biophysical and biochemical methods to elucidate their functions.
1. Protein Cage EngineeringProtein cage architecture has three modifiable surfaces; exterior, interior and subunit-subunit interfaces. These surfaces can be modified both genetically and chemically on demand. We can engineer these three surfaces for the purposes listed below by design.
 2. Targeted Delivery of Therapeutic or Diagnostic ReagentsNanobio-templates can be utilized as multivalent and targeted delivery vehicles through genetic and chemical modifications. Well defined 3-D structure and multiple addressible sites are beneficial for multi-functional nanoplatforms.
3. Protein engineering: Biosensings & Imaging Binding specificity and high affinity to any given target molecule are essential features for in vitro and/or in vivo diagnostics and for many other biotechnological and biomedical applications. Protein engineering allows constructing multifunctional biosensing & imaging components. 
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2023-12Compact and modular bioprobe: Integrating SpyCatcher/SpyTag recombinant proteins with zwitterionic polymer-coated quantum dotsKim, Sunghwan; Bae, Yoonji; Park, Sung Han, et alARTICLE130 Compact and modular bioprobe: Integrating SpyCatcher/SpyTag recombinant proteins with zwitterionic polymer-coated quantum dots
2023-11Development of recombinant secondary antibody mimics (rSAMs) for immunoassays through genetic fusion of monomeric alkaline phosphatase with antibody bindersPark, Jiyeon; Bae, Yoonji; Eom, Soomin, et alARTICLE208 Development of recombinant secondary antibody mimics (rSAMs) for immunoassays through genetic fusion of monomeric alkaline phosphatase with antibody binders
2023-03Lactate oxidase/vSIRPα conjugates efficiently consume tumor-produced lactates and locally produce tumor-necrotic H2O2 to suppress tumor growthKang, Yujin; Yeo, Mirae; Choi, Hyukjun, et alARTICLE771 Lactate oxidase/vSIRPα conjugates efficiently consume tumor-produced lactates and locally produce tumor-necrotic H2O2 to suppress tumor growth
2023-01Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growthChoi, Hyukjun; Yeo, Mirae; Kang, Yujin, et alARTICLE924 Lactate oxidase/catalase-displaying nanoparticles efficiently consume lactate in the tumor microenvironment to effectively suppress tumor growth
2022-12Tunable Physicomechanical and Drug Release Properties of In Situ Forming Thermoresponsive Elastin-like Polypeptide HydrogelsLee, Kangseok; Noh, Yeongjin; Bae, Yoonji, et alARTICLE866 Tunable Physicomechanical and Drug Release Properties of In Situ Forming Thermoresponsive Elastin-like Polypeptide Hydrogels
2022-10Highly sensitive pregnancy test kit via oriented antibody conjugation on brush-type ligand-coated quantum beadsKim, Sunghwan; Ahn, Yujin; Bae, Yoonji, et alARTICLE838 Highly sensitive pregnancy test kit via oriented antibody conjugation on brush-type ligand-coated quantum beads
2022-09TRAIL & EGFR affibody dual-display on a protein nanoparticle synergistically suppresses tumor growthJun, Heejin; Jang, Eunjung; Kim, Hansol, et alARTICLE1050 TRAIL & EGFR affibody dual-display on a protein nanoparticle synergistically suppresses tumor growth
2022-08Directing ricin-based immunotoxins with targeting affibodies and KDEL signal peptide to cancer cells effectively induces apoptosis and tumor suppressionPark, Seong Guk; Kim, Heeyeon; Jun, Heejin, et alARTICLE670 Directing ricin-based immunotoxins with targeting affibodies and KDEL signal peptide to cancer cells effectively induces apoptosis and tumor suppression
2022-04Application of periostin peptide-decorated self-assembled protein cage nanoparticles for therapeutic angiogenesisKim, Ba Reun; Yoon, Jung Won; Choi, Hyukjun, et alARTICLE508 Application of periostin peptide-decorated self-assembled protein cage nanoparticles for therapeutic angiogenesis
2022-01Construction of SARS-CoV-2 virus-like particles in plantMoon, Ki-Beom; Jeon, Jae-Heung; Choi, Hyukjun, et alARTICLE620 Construction of SARS-CoV-2 virus-like particles in plant
2021-07Target-switchable Gd(III)-DOTA/protein cage nanoparticle conjugates with multiple targeting affibody molecules as target selective T1 contrast agents for high-field MRIKim, Hansol; Jin, Seokha; Choi, Hyukjun, et alARTICLE549 Target-switchable Gd(III)-DOTA/protein cage nanoparticle conjugates with multiple targeting affibody molecules as target selective T1 contrast agents for high-field MRI
2021-07Load and Display: Engineering Encapsulin as a Modular Nanoplatform for Protein-Cargo Encapsulation and Protein-Ligand Decoration Using Split Intein and SpyTag/SpyCatcherChoi, Hyukjun; Eom, Soomin; Kim, Han-ul, et alARTICLE445 Load and Display: Engineering Encapsulin as a Modular Nanoplatform for Protein-Cargo Encapsulation and Protein-Ligand Decoration Using Split Intein and SpyTag/SpyCatcher
2021-06Development of HER2-Targeting-Ligand-Modified Albumin Nanoparticles Based on the SpyTag/SpyCatcher System for Photothermal TherapyLee, Changkyu; Kang, SebyungARTICLE382 Development of HER2-Targeting-Ligand-Modified Albumin Nanoparticles Based on the SpyTag/SpyCatcher System for Photothermal Therapy
2021-04Accessibility-dependent topology studies of membrane proteins using a SpyTag/SpyCatcher protein-ligation systemBae, Yoonji; Lee, Sang Kwon; Chae, Young Chan, et alARTICLE479 Accessibility-dependent topology studies of membrane proteins using a SpyTag/SpyCatcher protein-ligation system
2020-10HRP-conjugated plug-and-playable IgG-binding nanobodies as secondary antibody mimics in immunoassaysBae, Yoonji; Jang, Dong Gil; Eom, Soomin, et alARTICLE740 HRP-conjugated plug-and-playable IgG-binding nanobodies as secondary antibody mimics in immunoassays
2020-09Selective and Effective Cancer Treatments using Target‐Switchable Intracellular Bacterial Toxin Delivery SystemsPark, Seong Guk; Choi, Bongseo; Bae, Yoonji, et alARTICLE644 Selective and Effective Cancer Treatments using Target‐Switchable Intracellular Bacterial Toxin Delivery Systems
2020-04Development of Recombinant Immunoglobulin G-Binding Luciferase-Based Signal Amplifiers in ImmunoassaysEom, Soomin; Bae, Yoonji; Kim, Sunghwan, et alARTICLE604 Development of Recombinant Immunoglobulin G-Binding Luciferase-Based Signal Amplifiers in Immunoassays
2019-11Development of target-tunable P22 VLP-based delivery nanoplatforms using bacterial superglueKim, Hansol; Choi, Hyukjun; Bae, Yoonji, et alARTICLE634 Development of target-tunable P22 VLP-based delivery nanoplatforms using bacterial superglue
2018-11Protein Cage Nanoparticles as Delivery NanoplatformsChoi, Bongseo; Kim, Hansol; Choi, Hyukjun, et alARTICLE726 Protein Cage Nanoparticles as Delivery Nanoplatforms
2018-10Cloaking nanoparticles with protein corona shield for targeted drug deliveryOh, Jun Yong; Kim, Hansol; Palanikumar, L, et alARTICLE1217 Cloaking nanoparticles with protein corona shield for targeted drug delivery

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