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Kang, Sebyung (강세병)

Department
Department of Biological Sciences(생명과학과)
Website
https://sites.google.com/site/proteinnanobio
Lab
Protein Nanobio Lab. (단백질 나노바이오 연구실)
Research Keywords
바이오 센서, 바이오 이미징, 나노바이오기술, 단백질 공학, 단백질 나노입자, 세포질내 단백질 전달, Nanobiotechnology, Protein Engineering, Protein Nanoparticle-based Drug Delivery, Biosensors, Bioimaging
Research Interests
Our researches focus on utilizing protein based nanobio-templates for  biomedical and biomaterial applications. To achieve these goals, we are using various types of nanobio-templates, such as viral capsids, small protein cages, and functional proteins, and biophysical and biochemical methods to elucidate their functions.
1. Protein Cage EngineeringProtein cage architecture has three modifiable surfaces; exterior, interior and subunit-subunit interfaces. These surfaces can be modified both genetically and chemically on demand. We can engineer these three surfaces for the purposes listed below by design.
 2. Targeted Delivery of Therapeutic or Diagnostic ReagentsNanobio-templates can be utilized as multivalent and targeted delivery vehicles through genetic and chemical modifications. Well defined 3-D structure and multiple addressible sites are beneficial for multi-functional nanoplatforms.
3. Protein engineering: Biosensings & Imaging Binding specificity and high affinity to any given target molecule are essential features for in vitro and/or in vivo diagnostics and for many other biotechnological and biomedical applications. Protein engineering allows constructing multifunctional biosensing & imaging components. 
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Issue DateTitleAuthor(s)TypeViewAltmetrics
2021-04Accessibility-dependent topology studies of membrane proteins using a SpyTag/SpyCatcher protein-ligation systemBae, Yoonji; Lee, Sang Kwon; Chae, Young Chan, et alARTICLE19 Accessibility-dependent topology studies of membrane proteins using a SpyTag/SpyCatcher protein-ligation system
2020-10HRP-conjugated plug-and-playable IgG-binding nanobodies as secondary antibody mimics in immunoassaysBae, Yoonji; Jang, Dong Gil; Eom, Soomin, et alARTICLE162 HRP-conjugated plug-and-playable IgG-binding nanobodies as secondary antibody mimics in immunoassays
2020-09Selective and Effective Cancer Treatments using Target‐Switchable Intracellular Bacterial Toxin Delivery SystemsPark, Seong Guk; Choi, Bongseo; Bae, Yoonji, et alARTICLE132 Selective and Effective Cancer Treatments using Target‐Switchable Intracellular Bacterial Toxin Delivery Systems
2020-04Development of Recombinant Immunoglobulin G-Binding Luciferase-Based Signal Amplifiers in ImmunoassaysEom, Soomin; Bae, Yoonji; Kim, Sunghwan, et alARTICLE178 Development of Recombinant Immunoglobulin G-Binding Luciferase-Based Signal Amplifiers in Immunoassays
2019-11Development of target-tunable P22 VLP-based delivery nanoplatforms using bacterial superglueKim, Hansol; Choi, Hyukjun; Bae, Yoonji, et alARTICLE227 Development of target-tunable P22 VLP-based delivery nanoplatforms using bacterial superglue
2018-11Protein Cage Nanoparticles as Delivery NanoplatformsChoi, Bongseo; Kim, Hansol; Choi, Hyukjun, et alARTICLE341 Protein Cage Nanoparticles as Delivery Nanoplatforms
2018-10Cloaking nanoparticles with protein corona shield for targeted drug deliveryOh, Jun Yong; Kim, Hansol; Palanikumar, L, et alARTICLE572 Cloaking nanoparticles with protein corona shield for targeted drug delivery
2018-08Fabrication of Nanoreaction Clusters with Dual‐Functionalized Protein Cage Nanobuilding BlocksChoi, Hyukjun; Choi, Bongseo; Kim, Gwang Joong, et alARTICLE522 Fabrication of Nanoreaction Clusters with Dual‐Functionalized Protein Cage Nanobuilding Blocks
2018-07Engineering Tunable Dual Functional Protein Cage Nanoparticles Using Bacterial SuperglueBae, Yoonji; Kim, Gwang Joong; Kim, Hansol, et alARTICLE408 Engineering Tunable Dual Functional Protein Cage Nanoparticles Using Bacterial Superglue
2017-09Nickel-Catalyzed Azide-Alkyne Cycloaddition to Access 1,5-Disubstituted 1,2,3-Triazoles in Air and WaterKim, Woo Gyum; Kang, Mi Eun; Lee, Jae Bin, et alARTICLE1104 Nickel-Catalyzed Azide-Alkyne Cycloaddition to Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water
2016-12Plug-and-playable fluorescent cell imaging modular toolkits using the bacterial superglue, SpyTag/SpyCatcherMoon, Hyojin; Bae, Yoonji; Kim, Hansol, et alARTICLE579 Plug-and-playable fluorescent cell imaging modular toolkits using the bacterial superglue, SpyTag/SpyCatcher
2016-09Covalent Conjugation of Small-Molecule Adjuvants to Nanoparticles Induces Robust Cytotoxic T Cell Responses via DC ActivationKim, Woo Gyum; Choi, Bongseo; Yang, Hyun-Ji, et alARTICLE732 Covalent Conjugation of Small-Molecule Adjuvants to Nanoparticles Induces Robust Cytotoxic T Cell Responses via DC Activation
2016-08Effective Delivery of Antigen-Encapsulin Nanoparticle Fusions to Dendritic Cells Leads to Antigen-Specific Cytotoxic T Cell Activation and Tumor RejectionChoi, Bongseo; Moon, Hyojin; Hong, Jung Joon, et alARTICLE564 Effective Delivery of Antigen-Encapsulin Nanoparticle Fusions to Dendritic Cells Leads to Antigen-Specific Cytotoxic T Cell Activation and Tumor Rejection
2016-04A Recombinant Secondary Antibody Mimic as a Target-specific Signal Amplifier and an Antibody Immobilizer in ImmunoassaysMin, Junseon; Song, Eun Kyung; Kim, Hansol, et alARTICLE770 A Recombinant Secondary Antibody Mimic as a Target-specific Signal Amplifier and an Antibody Immobilizer in Immunoassays
2016-02Development of an antibody-binding modular nanoplatform for antibody-guided targeted cell imaging and deliveryKim, Hansol; Kang, Young Ji; Min, Junseon, et alARTICLE599 Development of an antibody-binding modular nanoplatform for antibody-guided targeted cell imaging and delivery
2015-10Lumazine Synthase Protein Nanoparticle-Gd(III)-DOTA Conjugate as a T1 contrast agent for high-field MRISong, YoungKyu; Kang, Young Ji; Jung, Hoesu, et alARTICLE924 Lumazine Synthase Protein Nanoparticle-Gd(III)-DOTA Conjugate as a T1 contrast agent for high-field MRI
2015-07An enhanced ascorbate peroxidase 2/antibody-binding domain fusion protein (APEX2-ABD) as a recombinant target-specific signal amplifierLee, Jisu; Song, Eun Kyung; Bae, Yoonji, et alARTICLE979 An enhanced ascorbate peroxidase 2/antibody-binding domain fusion protein (APEX2-ABD) as a recombinant target-specific signal amplifier
2015-05Surface plasmon resonance: a versatile technique for biosensor applicationsNguyen, Hoang Hiep; Park, Jeho; Kang, Sebyung, et alARTICLE800 Surface plasmon resonance: a versatile technique for biosensor applications
2015-03Mesoporous monoliths of inverse bicontinuous cubic phases of block copolymer bilayersPark, Chiyoung; La, Yunju; An, Tae Hyun, et alARTICLE1213 Mesoporous monoliths of inverse bicontinuous cubic phases of block copolymer bilayers
2014-11Genetically engineering encapsulin protein cage nanoparticle as a SCC-7 cell targeting optical nanoprobeMoon, Hyojin; Lee, Jisu; Kim, Hansol, et alARTICLE582 Genetically engineering encapsulin protein cage nanoparticle as a SCC-7 cell targeting optical nanoprobe

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