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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 855 | - |
dc.citation.startPage | 843 | - |
dc.citation.title | JOURNAL OF GENERAL VIROLOGY | - |
dc.citation.volume | 85 | - |
dc.contributor.author | Lim, Chunghun | - |
dc.contributor.author | Seo, Taegun | - |
dc.contributor.author | Jung, Jun | - |
dc.contributor.author | Choe, Joonho | - |
dc.date.accessioned | 2023-12-22T11:06:39Z | - |
dc.date.available | 2023-12-22T11:06:39Z | - |
dc.date.created | 2015-01-05 | - |
dc.date.issued | 2004-04 | - |
dc.description.abstract | Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) plays a pivotal role in the maintenance of the virus genome in latently infected cells. LANA1 links virus genomes to host chromosomes via a C-terminal DNA-binding domain which interacts with the sequences located in terminal repeats (TRs) of the virus genome and via an N-terminal chromosome-binding sequence which associates with the host chromosomes, respectively. Recent data suggest that LANA1 also actively participates in the replication of KSHV TR-containing plasmid in the transient DNA replication assay. In this report, it was found that C33A and COS-1, but not NIH/3T3, cell lines are permissive for the transient replication of KSHV TR-containing plasmid. Using several LANA1-deletion mutants, the minimum domain of LANA1 required for replication activity was also determined. In addition, the N terminus of LANA1 inhibited the transient replication systems of KSHV and Epstein-Barr virus (EBV) in transiently transfected 293 and 293T cells, but the C terminus of LANA1 specifically inhibited the transient replication system of KSHV in other cell lines. Consistent with previous reports, these data further emphasize the functional importance of the N terminus of LANA1 on replication from the KSHV latent origin of DNA replication. | - |
dc.identifier.bibliographicCitation | JOURNAL OF GENERAL VIROLOGY, v.85, pp.843 - 855 | - |
dc.identifier.doi | 10.1099/vir.0.19510-0 | - |
dc.identifier.issn | 0022-1317 | - |
dc.identifier.scopusid | 2-s2.0-1842843635 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/9837 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=1842843635 | - |
dc.identifier.wosid | 000220628700009 | - |
dc.language | 영어 | - |
dc.publisher | SOC GENERAL MICROBIOLOGY | - |
dc.title | Identification of a virus trans-acting regulatory element on the latent DNA replication of Kaposi's sarcoma-associated herpesvirus | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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