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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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Mapping Human Genetic Diversity in Asia

Cited 175 times inthomson ciCited 182 times inthomson ci
Title
Mapping Human Genetic Diversity in Asia
Author
Abdulla, Mahmood AmeenAhmed, IkhlakAssawamakin, AnunchaiBhak, Jong HwaBrahmachari, Samir K.Calacal, Gayvelline C.Chaurasia, AmitChen, Chien-HsiunChen, JiemingChen, Yuan-TsongChu, JiayouCutiongco-de la Paz, Eva Maria C.De Ungria, Maria Corazon A.Delfin, Frederick C.Edo, JuliFuchareon, SuthatGhang, HoGojobori, TakashiHan, JunsongHo, Sheng-FengHoh, Boon PengHuang, WeiInoko, HidetoshiJha, PankajJinam, Timothy A.Jin, LiJung, JongsunKangwanpong, DaoroongKampuansai, JatupolKennedy, Giulia C.Khurana, PreetiKim, Hyung-LaeKim, KwangjoongKim, SangsooKim, Woo-YeonKimm, KuchanKimura, RyosukeKoike, TomohiroKulawonganunchai, SupasakKumar, VikrantLai, Poh SanLee, Jong-YoungLee, SunghoonLiu, Edison T.Majumder, Partha P.Mandapati, Kiran KumarMarzuki, SangkotMitchell, WayneMukerji, MitaliNaritomi, KenjiNgamphiw, ChumpolNiikawa, NorioNishida, NaoOh, BermseokOh, SanghoOhashi, JunOka, AkiraOng, RickPadilla, Carmencita D.Palittapongarnpim, PrasitPerdigon, Henry B.Phipps, Maude ElviraPng, EileenSakaki, YoshiyukiSalvador, Jazelyn M.Sandraling, YulianaScaria, VinodSeielstad, MarkSidek, Mohd RosSinha, AmitSrikummool, MetaweeSudoyo, HerawatiSugano, SumioSuryadi, HelenaSuzuki, YoshiyukiTabbada, Kristina A.Tan, AdrianTokunaga, KatsushiTongsima, SissadesVillamor, Lilian P.Wang, EricWang, YingWang, HaifengWu, Jer-YuarnXiao, HuashengXu, ShuhuaYang, Jin OkShugart, Yin YaoYoo, Hyang-SookYuan, WentaoZhao, GuopingZilfalil, Bin Alwi
Keywords
POPULATION-STRUCTURE; WIDE ANALYSIS; ADMIXTURE; GEOGRAPHY; UYGHURS; HISTORY; EUROPE
Issue Date
2009-12
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Citation
SCIENCE, v.326, no.5959, pp.1541 - 1545
Abstract
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
URI
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DOI
10.1126/science.1177074
ISSN
0036-8075
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BME_Journal Papers
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