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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS


Gene Flow between the Korean Peninsula and Its Neighboring Countries

DC Field Value Language Jung, Jongsun ko Kang, Hoyoung ko Cho, Yoon Shin ko Oh, Ji Hee ko Ryu, Min Hyung ko Chung, Hye Won ko Seo, Jeong-Sun ko Lee, Jong-Eun ko Oh, Bermseok ko Bhak, Jong Hwa ko Kim, Hyung-Lae ko 2014-12-26T00:13:51Z - 2014-12-24 ko 2010-07 -
dc.identifier.citation PLOS ONE, v.5, no.7, pp. - ko
dc.identifier.issn 1932-6203 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract SNP markers provide the primary data for population structure analysis. In this study, we employed whole-genome autosomal SNPs as a marker set (54,836 SNP markers) and tested their possible effects on genetic ancestry using 320 subjects covering 24 regional groups including Northern (=16) and Southern (=3) Asians, Amerindians (=1), and four HapMap populations (YRI, CEU, JPT, and CHB). Additionally, we evaluated the effectiveness and robustness of 50K autosomal SNPs with various clustering methods, along with their dependencies on recombination hotspots (RH), linkage disequilibrium (LD), missing calls and regional specific markers. The RH- and LD-free multi-dimensional scaling (MDS) method showed a broad picture of human migration from Africa to North-East Asia on our genome map, supporting results from previous haploid DNA studies. Of the Asian groups, the East Asian group showed greater differentiation than the Northern and Southern Asian groups with respect to Fst statistics. By extension, the analysis of monomorphic markers implied that nine out of ten historical regions in South Korea, and Tokyo in Japan, showed signs of genetic drift caused by the later settlement of East Asia (South Korea, Japan and China), while Gyeongju in South East Korea showed signs of the earliest settlement in East Asia. In the genome map, the gene flow to the Korean Peninsula from its neighboring countries indicated that some genetic signals from Northern populations such as the Siberians and Mongolians still remain in the South East and West regions, while few signals remain from the early Southern lineages ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.subject DNA ko
dc.subject INDIVIDUALS ko
dc.subject GENOME ko
dc.subject ASIA ko
dc.title Gene Flow between the Korean Peninsula and Its Neighboring Countries ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-77955612081 ko
dc.identifier.wosid 000280520200020 ko
dc.type.rims ART ko
dc.description.wostc 7 *
dc.description.scopustc 8 * 2015-05-06 * 2014-12-24 *
dc.identifier.doi 10.1371/journal.pone.0011855 ko
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