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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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Gene Flow between the Korean Peninsula and Its Neighboring Countries

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dc.contributor.author Jung, Jongsun ko
dc.contributor.author Kang, Hoyoung ko
dc.contributor.author Cho, Yoon Shin ko
dc.contributor.author Oh, Ji Hee ko
dc.contributor.author Ryu, Min Hyung ko
dc.contributor.author Chung, Hye Won ko
dc.contributor.author Seo, Jeong-Sun ko
dc.contributor.author Lee, Jong-Eun ko
dc.contributor.author Oh, Bermseok ko
dc.contributor.author Bhak, Jong Hwa ko
dc.contributor.author Kim, Hyung-Lae ko
dc.date.available 2014-12-26T00:13:51Z -
dc.date.created 2014-12-24 ko
dc.date.issued 2010-07 -
dc.identifier.citation PLOS ONE, v.5, no.7, pp. - ko
dc.identifier.issn 1932-6203 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/9655 -
dc.identifier.uri http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955612081 ko
dc.description.abstract SNP markers provide the primary data for population structure analysis. In this study, we employed whole-genome autosomal SNPs as a marker set (54,836 SNP markers) and tested their possible effects on genetic ancestry using 320 subjects covering 24 regional groups including Northern (=16) and Southern (=3) Asians, Amerindians (=1), and four HapMap populations (YRI, CEU, JPT, and CHB). Additionally, we evaluated the effectiveness and robustness of 50K autosomal SNPs with various clustering methods, along with their dependencies on recombination hotspots (RH), linkage disequilibrium (LD), missing calls and regional specific markers. The RH- and LD-free multi-dimensional scaling (MDS) method showed a broad picture of human migration from Africa to North-East Asia on our genome map, supporting results from previous haploid DNA studies. Of the Asian groups, the East Asian group showed greater differentiation than the Northern and Southern Asian groups with respect to Fst statistics. By extension, the analysis of monomorphic markers implied that nine out of ten historical regions in South Korea, and Tokyo in Japan, showed signs of genetic drift caused by the later settlement of East Asia (South Korea, Japan and China), while Gyeongju in South East Korea showed signs of the earliest settlement in East Asia. In the genome map, the gene flow to the Korean Peninsula from its neighboring countries indicated that some genetic signals from Northern populations such as the Siberians and Mongolians still remain in the South East and West regions, while few signals remain from the early Southern lineages ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher PUBLIC LIBRARY SCIENCE ko
dc.subject POPULATION-STRUCTURE ko
dc.subject DNA ko
dc.subject INDIVIDUALS ko
dc.subject GENOME ko
dc.subject ASIA ko
dc.title Gene Flow between the Korean Peninsula and Its Neighboring Countries ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-77955612081 ko
dc.identifier.wosid 000280520200020 ko
dc.type.rims ART ko
dc.description.wostc 7 *
dc.description.scopustc 8 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-12-24 *
dc.identifier.doi 10.1371/journal.pone.0011855 ko
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