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Bhak, Jong
KOrean GenomIcs Center(KOGIC)
Research Interests
  • Geromics, genomics, bioinformatics, protein Engineering, OMICS

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The Genetic Basis of White Tigers

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Title
The Genetic Basis of White Tigers
Author
Xu, XiaoDong, Gui-XinHu, Xue-SongMiao, LinZhang, Xue-LiZhang, De-LuYang, Han-DongZhang, Tian-YouZou, Zheng-TingZhang, Ting-TingZhuang, YanBhak, Jong HwaCho, Yun SungDai, Wen-TaoJiang, Tai-JiaoXie, CanLi, RuiqiangLuo, Shu-Jin
Keywords
OCULOCUTANEOUS ALBINISM TYPE-4; MATP GENE; MUTATIONS; PIGMENTATION; POPULATION; POLYMORPHISMS; TRAFFICKING; TRANSPORTER; JAPANESE; FELIDAE
Issue Date
2013-06
Publisher
CELL PRESS
Citation
CURRENT BIOLOGY, v.23, no.11, pp.1031 - 1035
Abstract
The white tiger, an elusive Bengal tiger (Panthera tigris tigris) variant with white fur and dark stripes, has fascinated humans for centuries ever since its discovery in the jungles of India [1]. Many white tigers in captivity are inbred in order to maintain this autosomal recessive trait [2-5] and consequently suffer some health problems, leading to the controversial speculation that the white tiger mutation is perhaps a genetic defect [6]. However, the genetic basis of this phenotype remains unknown. Here, we conducted genome-wide association mapping with restriction-site-associated DNA sequencing (RAD-seq) in a pedigree of 16 captive tigers segregating at the putative white locus, followed by whole-genome sequencing (WGS) of the three parents. Validation in 130 unrelated tigers identified the causative mutation to be an amino acid change (A477V) in the transporter protein SLC45A2. Three-dimensional homology modeling suggests that the substitution may partially block the transporter channel cavity and thus affect melanogenesis. We demonstrate the feasibility of combining RAD-seq and WGS to rapidly map exotic variants in nonmodel organisms. Our results identify the basis of the longstanding white tiger mystery as the same gene underlying color variation in human, horse, and chicken and highlight its significance as part of the species' natural polymorphism that is viable in the wild.
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DOI
10.1016/j.cub.2013.04.054
ISSN
0960-9822
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BME_Journal Papers
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