There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 60784 | - |
dc.citation.number | 105 | - |
dc.citation.startPage | 60776 | - |
dc.citation.title | RSC ADVANCES | - |
dc.citation.volume | 4 | - |
dc.contributor.author | Dinda, Joydev | - |
dc.contributor.author | Nandy, Abhishek | - |
dc.contributor.author | Rana, Bidyut Kumar | - |
dc.contributor.author | Bertolasi, Valerio | - |
dc.contributor.author | Saha, Krishna Das | - |
dc.contributor.author | Bielawski, Christopher W. | - |
dc.date.accessioned | 2023-12-22T02:07:07Z | - |
dc.date.available | 2023-12-22T02:07:07Z | - |
dc.date.created | 2014-12-09 | - |
dc.date.issued | 2014-11 | - |
dc.description.abstract | Starting from the proligand 1-methyl-2-pyridin-2-yl-2H-imidazo[1,5-a]pyridin-4-ylium chloride (1 HCl), three novel complexes [Ag(1)Cl] (2), [Au(1)Cl] (3) and [Au(1)Cl3] (4) were synthesized and characterized using various spectroscopic techniques. In addition, the structure of 2 was elucidated using single crystal X-ray diffraction analysis, which revealed that the carbene nucleus and the chloride ion bound to the silver(I) were nearly linear (165.37(9)°). The gold(I)-NHC complex 3 was synthesized via transmetallation from the aforementioned silver complex 2. Similarly, treatment of 3 with Au(SMe2)Cl afforded 4, ostensibly via a disproportionation process. The cytotoxicities of complexes 2, 3, and 4 were examined against HepG2 (human hepatocellular carcinoma), HCT 116 (human colorectal carcinoma), A549 (human lung adenocarcinoma), and MCF-7 (human breast adenocarcinoma) cells. Au(I)-NHC complex 3 exhibited a cytotoxicity that was similar to that of cisplatin towards all the four cancer cell lines tested; by comparison, Ag(I) NHC complex 2 and Au(III) NHC complex 4 appeared relatively less potent. Complex 3 was found to induce apoptosis in HepG2 cells. | - |
dc.identifier.bibliographicCitation | RSC ADVANCES, v.4, no.105, pp.60776 - 60784 | - |
dc.identifier.doi | 10.1039/c4ra09591j | - |
dc.identifier.issn | 2046-2069 | - |
dc.identifier.scopusid | 2-s2.0-84912103783 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/9401 | - |
dc.identifier.url | https://pubs.rsc.org/en/Content/ArticleLanding/2014/RA/C4RA09591J#!divAbstract | - |
dc.identifier.wosid | 000345655600043 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Cytotoxicity of silver(I), gold(I) and gold(III) complexes of a pyridine wingtip substituted annelated N-heterocyclic carbene | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.