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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C


2,2 ',4,6,6 '-pentachlorobiphenyl induces apoptosis in human monocytic cells

DC Field Value Language Shin, KJ ko Bae, SS ko Hwang, YA ko Seo, Jeong Kon ko Ryu, SH ko Suh, Pann-Ghill ko 2014-11-21T00:12:01Z - 2014-11-19 ko 2000-11 ko
dc.identifier.citation TOXICOLOGY AND APPLIED PHARMACOLOGY, v.169, no.1, pp.1 - 7 ko
dc.identifier.issn 0041-008X ko
dc.identifier.uri -
dc.description.abstract Polychlorinated biphenyls (PCBs) are a group of persistent and widely dispersed environmental pollutants, some of which may be immunotoxic. In the present study, we investigated the effect of PCBs on immune system by assessing apoptotic cell death in human monocytic U937 cells. Among the various congeners tested, 2,2',4,6,6'-pentachlorobiphenyl (PeCB), a highly ortho-substituted congener, specifically induced DNA fragmentation, a hallmark of apoptosis, while the other examined di-, tri-, tetra-, and pentachlorobiphenyls did not. To further study the 2,2',4,6,6'-PeCB-induced cell death, various features of apoptosis were examined. 2,2',4,6,6'-PeCB caused a decrease in cell viability and induced cellular morphologic features characteristic of apoptosis such as chromatin aggregation and apoptotic bodies. In addition, caspase-3, an executioner of apoptosis, was activated and its substrate, poly(ADP-ribose) polymerase (PARP), was cleaved during 2,2',4,6,6'-PeCB-induced apoptosis. In contrast, 3,3',4,4',5-PeCB, a congener of coplanar structure, as well as 2,3,7,8-TCDD did not induce apoptosis in these human monocytic cells, although they potently induced CYP 1A1 in human hepatoma Hep G2 cells. Taken together, the data indicate that 2,2',4,6,6'-PeCB induces apoptosis in human monocytic cells through a mechanism that is independent of the arylhydrocarbon receptor. This suggests a possibly separate mechanism by which PCBs cause immunosuppression. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.title 2,2 ',4,6,6 '-pentachlorobiphenyl induces apoptosis in human monocytic cells ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0034669046 ko
dc.identifier.wosid 000165627600001 ko
dc.type.rims ART ko
dc.description.wostc 35 *
dc.description.scopustc 35 * 2015-05-06 * 2014-11-19 *
dc.identifier.doi 10.1006/taap.2000.9034 ko
dc.identifier.url ko
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