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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C


Purification and Characterization of a New Galactoside Specific Lectin from Trichosanthes Kirlowii Root

DC Field Value Language Yun, Doo Hee ko Park, Eun Ju ko Park, Jong Ok ko Lee, Young Han ko Seo, Jeong Kon ko Ryu, Sung Ho ko Suh, Pann-Ghill ko Kim, Hee Sook ko 2014-11-21T00:07:37Z - 2014-11-20 ko 1995-01 ko
dc.identifier.citation BMB REPORTS, v.28, no.1, pp.6 - 11 ko
dc.identifier.issn 1976-6696 ko
dc.identifier.uri -
dc.description.abstract A new lectin, named Tf~A, was purified from Trichosanthes kirilowii root by acid-treated Sepharose 6B, Mono-Q, and TSK-gel 3000SW column sequential chromatography. The lectin appeared homogeneous by native gel electrophoresis at pH 4.3 and gave two protein bands of Mr=31 and 28 kDa by SDS-PAGE. The N-terminal amino acid sequences of the polypeptides of TRA have not been reported in amino acid sequences of the lectins. TRA lectin fomoed a precipitate with asialofetuin, neuraminidase-treated fetuin. A sugar inhibition assay indicated that N-acetyl-D-galactosamine, among the monosaccharides tested, was the most potent inhibitor of TRA-induced hemagglutination. Asialofetuin showed a 260-times stronger inhibitory activity than N-acetyl-D-galactosamine. TRA lectin also showed agglutination with normal leukocytes and lymphoma cells, but not with premature hemopoietic cells. These results suggest that TRA is a novel plant lectin. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.title Purification and Characterization of a New Galactoside Specific Lectin from Trichosanthes Kirlowii Root ko
dc.type ARTICLE ko
dc.type.rims ART ko
dc.identifier.url ko
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