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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Targeted label-free quantitative analysis of secretory proteins from adipocytes in response to oxidative stress

DC Field Value Language
dc.contributor.author Choi, S. ko
dc.contributor.author Kim, J. ko
dc.contributor.author Yea, K. ko
dc.contributor.author Suh, Pann-Ghill ko
dc.contributor.author Kim, J. ko
dc.contributor.author Ryu, S.H. ko
dc.date.available 2014-11-21T00:06:01Z -
dc.date.created 2014-11-19 ko
dc.date.issued 2010-06 ko
dc.identifier.citation ANALYTICAL BIOCHEMISTRY, v.401, no.2, pp.196 - 202 ko
dc.identifier.issn 0003-2697 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/9003 -
dc.description.abstract Adipocytes are well known to release regulation factors associated with metabolic disorders. In particular, increased oxidative stress in adipocytes contributes to dysregulation of adipokine production. In this study, we applied relative quantitative proteomic analysis based on label-free multiple reaction monitoring (MRM) to discover biological changes of adipokines under oxidative stress. Among a total of 194 identified proteins, 8 proteins were selected and quantified between control and hydrogen peroxide (H2O2)-treated groups by label-free MRM quantification. The secretion levels of matrix metalloproteinase-2 (MMP-2), stromal cell-derived factor-1 (SDF-1, CXCL12), resistin, and complement factor D (CFD, adipsin) decreased, whereas the secretion levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) and aldolase A increased. Here we suggest that our study with label-free quantitative analysis will contribute to the efficient quantitative analysis of targeted proteins in complex mixtures and specifically to a better understanding of changes of adipokines under oxidative stress. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher ACADEMIC PRESS INC ELSEVIER SCIENCE ko
dc.title Targeted label-free quantitative analysis of secretory proteins from adipocytes in response to oxidative stress ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-77952851155 ko
dc.identifier.wosid 000277397400004 ko
dc.type.rims ART ko
dc.description.wostc 10 *
dc.description.scopustc 11 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-11-19 *
dc.identifier.doi 10.1016/j.ab.2010.03.006 ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77952851155 ko
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