Electrocorticography Microdisplay for High Precision Intraoperative Brain Mapping

Abstract

A flexible, thin-film brain interface device was developed to facilitate real-time recording and visualization of brain activity directly from the brain's surface. The device integrates thousands of GaN micro-LED pixels seamlessly into the backside of the brain sensory grid. An intracranial electroencephalogram (iEEG) microdisplay was developed to enable real-time visualization of neuronal activity directly on the brain's surface during surgery. This device integrates GaN LEDs with brain sensory grids (electrocorticography, ECoG) to provide high-resolution spatial mapping of cortical functions and pathological activities. Preclinical studies in rats and pigs demonstrated the device’s capability to identify cortical boundaries and track epileptiform activities with dual-color displays. This advancement holds potential for enhancing intraoperative brain mapping and neurosurgical outcomes.