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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

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Small Molecule Modulators of Copper-Induced A beta Aggregation

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dc.contributor.author Hindo, Sarmad S. ko
dc.contributor.author Mancino, Allana M. ko
dc.contributor.author Braymer, Joseph J. ko
dc.contributor.author Liu, Yihong ko
dc.contributor.author Vivekanandan, Subramanian ko
dc.contributor.author Ramamoorthy, Ayyalusamy ko
dc.contributor.author Lim, Mi Hee ko
dc.date.available 2014-11-12T00:43:31Z -
dc.date.created 2014-11-11 ko
dc.date.issued 2009-11 -
dc.identifier.citation JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.131, no.46, pp.16663 - 16665 ko
dc.identifier.issn 0002-7863 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/8622 -
dc.identifier.uri http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70450202390 ko
dc.description.abstract (Chemical Equation Presented) Our design of bifunctional metal chelators as chemical probes and potential therapeutics for Alzheimer's disease (AD) is based on the incorporation of a metal binding moiety into structural frameworks of Aβ aggregate-imaging agents. Using this strategy, two compounds 2-[4-(dimethylamino)phenyl]imidazo[1,2-a]pyridine-8-ol (1) and N 1,N1-dimethyl-N4-(pyridin-2-ylmethylene) benzene-1,4-diamine (2) were prepared and characterized. The bifunctionality for metal chelation and Aβ interaction of 1 and 2 was verified by spectroscopic methods. Furthermore, the reactivity of 1 and 2 with Cu II-associated Aβ aggregates was investigated. The modulation of CuII-triggered Aβ aggregation by 1 and 2 was found to be more effective than that by the known metal chelating agents CQ, EDTA, and phen. These studies suggest a new class of multifunctional molecules for the development of chemical tools to unravel metal-associated events in AD and potential therapeutic agents for metal-ion chelation therapy. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher AMER CHEMICAL SOC ko
dc.subject Alzheimer's disease ko
dc.subject Bifunctional ko
dc.subject Chelating agent ko
dc.subject Chemical equations ko
dc.subject Chemical probes ko
dc.subject Chemical tools ko
dc.subject Imaging agent ko
dc.subject Metal binding ko
dc.subject Metal chelation ko
dc.subject Metal chelator ko
dc.subject Metal-ion chelation ko
dc.subject Multi-functional molecules ko
dc.subject Small molecules ko
dc.subject Spectroscopic method ko
dc.subject Structural frameworks ko
dc.subject Therapeutic agents ko
dc.title Small Molecule Modulators of Copper-Induced A beta Aggregation ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-70450202390 ko
dc.identifier.wosid 000272185400030 ko
dc.type.rims ART ko
dc.description.wostc 91 *
dc.description.scopustc 90 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-11-11 *
dc.identifier.doi 10.1021/ja907045h ko
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