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DC Field | Value | Language |
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dc.citation.endPage | 291 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 284 | - |
dc.citation.title | METALLOMICS | - |
dc.citation.volume | 3 | - |
dc.contributor.author | Choi, Jung-Suk | - |
dc.contributor.author | Braymer, Joseph J. | - |
dc.contributor.author | Park, Se Kyung | - |
dc.contributor.author | Mustafa, Shaik | - |
dc.contributor.author | Chae, Junghyun | - |
dc.contributor.author | Lim, Mi Hee | - |
dc.date.accessioned | 2023-12-22T06:37:59Z | - |
dc.date.available | 2023-12-22T06:37:59Z | - |
dc.date.created | 2014-11-11 | - |
dc.date.issued | 2011 | - |
dc.description.abstract | Metal ions associated with amyloid-β (Aβ) species have been suggested to be involved in neurodegeneration leading to the progression of Alzheimer's disease (AD). The role of metal-involved Aβ species in AD neuropathogenesis, however, is not fully elucidated. In order to advance this understanding and contribute to the therapeutic development for AD, the rational structure-based design of small molecules that specifically target metal ions surrounded by Aβ species has recently received increased attention. To date, only a few compounds have been fashioned for this purpose. Herein, we report the design strategy, synthesis, characterization, and reactivity of new bifunctional IMPY derivatives K1 and K2. Using UV-vis and high-resolution two-dimensional (2D) NMR spectroscopy, the bifunctionality of K1 and K2 (metal chelation and Aβ interaction) was confirmed. These bifunctional IMPY derivatives showed preferential reactivity toward metal-induced Aβ aggregation over metal-free conditions in both in vitro inhibition and disaggregation experiments. Taken together, this study provides another example of a bifunctional small molecule framework that can target metal ions associated with Aβ species. | - |
dc.identifier.bibliographicCitation | METALLOMICS, v.3, no.3, pp.284 - 291 | - |
dc.identifier.doi | 10.1039/c0mt00077a | - |
dc.identifier.issn | 1756-5901 | - |
dc.identifier.scopusid | 2-s2.0-79952522223 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/8621 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79952522223 | - |
dc.identifier.wosid | 000288126200009 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Synthesis and characterization of IMPY derivatives that regulate metal-induced amyloid-beta aggregation | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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