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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

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Characterization of pyridinylimine and pyridinylmethylamine derivatives and their corresponding metal complexese

Cited 8 times inthomson ciCited 6 times inthomson ci
Title
Characterization of pyridinylimine and pyridinylmethylamine derivatives and their corresponding metal complexese
Author
Braymer, Joseph J.Merrill, Nathan M.Lim, Mi Hee
Keywords
Bioinorganic chemistry; Metal complexes of pyridinylimine and pyridinylmethylamine derivatives; Spectroscopic studies; X-ray crystal structure determination
Issue Date
2012-01
Publisher
ELSEVIER SCIENCE SA
Citation
INORGANICA CHIMICA ACTA, v.380, no., pp.261 - 268
Abstract
Bidentate pyridinylimine (L1-a and L1-b) and pyridinylmethylamine (L2-a and L2-b) derivatives have recently received attention due to their potential use as chemical reagants that can target metal-associated amyloid-β (Aβ) species and modulate metal-induced Aβ aggregation and neurotoxicity in vitro and in living cells. Herein, we report the characterization of these bidentate ligands and their corresponding metal complexes by X-ray crystallography and spectroscopic methods, including UV-Vis spectroscopy (UV-Vis), nuclear magnetic resonance spectroscopy (NMR), and Fourier transform infrared spectroscopy (FT-IR). Our studies presented how the different structural moieties of ligand frameworks (L1-a, L1-b, L2-a, and L2-b), in addition to effects of metal binding, contribute to variations in structure and chemical environments of the ligands and their corresponding metal complexes.
URI
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DOI
10.1016/j.ica.2011.08.056
ISSN
0020-1693
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PHY_Journal Papers
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