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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS

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Untangling Amyloid-beta, Tau, and Metals in Alzheimer's Disease

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dc.contributor.author Lee, Sanghyun ko
dc.contributor.author Liu, Yuzhong ko
dc.contributor.author Liu, Y. ko
dc.contributor.author Lim, Mi Hee ko
dc.date.available 2014-11-12T00:43:14Z -
dc.date.created 2014-11-11 ko
dc.date.issued 2013-05 -
dc.identifier.citation ACS CHEMICAL BIOLOGY, v.8, no.5, pp.856 - 865 ko
dc.identifier.issn 1554-8929 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/8611 -
dc.identifier.uri http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84878034899 ko
dc.description.abstract Protein misfolding and metal ion dyshomeostasis are believed to underlie numerous neurodegenerative diseases, including Alzheimer's disease (AD). The pathological hallmark of AD is accumulation of misfolded amyloid-β (Aβ) peptides and hyperphosphorylated tau (ptau) proteins in the brain. Since AD etiology remains unclear, several hypotheses have emerged to elucidate its pathological pathways. The amyloid cascade hypothesis, a leading hypothesis for AD development, advocates Aβ as the principal culprit. Additionally, evidence suggests that tau may contribute to AD pathology. Aβ and tau have also been shown to impact each other's pathology either directly or indirectly. Furthermore, metal ion dyshomeostasis is associated with these misfolded proteins. Metal interactions with Aβ and tau/ptau also influence their aggregation properties and neurotoxicity. Herein, we present current understanding on the roles of Aβ, tau, and metal ions, placing equal emphasis on each of these proposed features, as well as their inter-relationships in AD pathogenesis. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher AMER CHEMICAL SOC ko
dc.subject A-BETA ko
dc.subject NEUROFIBRILLARY TANGLES ko
dc.subject OXIDATIVE STRESS ko
dc.subject IN-VITRO ko
dc.subject NEURODEGENERATIVE DISORDERS ko
dc.subject STRUCTURAL-CHARACTERIZATION ko
dc.subject PROTEIN OLIGOMERIZATION ko
dc.subject TRANSGENIC MICE ko
dc.subject MOUSE MODEL ko
dc.subject PHF-TAU ko
dc.title Untangling Amyloid-beta, Tau, and Metals in Alzheimer's Disease ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84878034899 ko
dc.identifier.wosid 000319720700001 ko
dc.type.rims ART ko
dc.description.wostc 34 *
dc.description.scopustc 19 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-11-11 *
dc.identifier.doi 10.1021/cb400080f ko
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