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Lim, Mi Hee
MetalloNeuroChemistry Lab (MNCL)
Research Interests
  • Neurodegenerative disease, small molecule design, network between metal, proteins, and ROS


Recent development of bifunctional small molecules to study metal-amyloid-β species in Alzheimer's disease

DC Field Value Language Joseph J. Braymer, ko Detoma, A.S. ko Choi, J.-S. ko Ko, K.S.a ko Lim, Mi Hee ko 2014-11-12T00:41:38Z - 2014-11-11 ko 2011 ko
dc.identifier.citation International Journal of Alzheimer's Disease, v.2011, no., pp.623051 - ko
dc.identifier.issn 2090-8024 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative disease related to the deposition of aggregated amyloid-β (Aβ) peptides in the brain. It has been proposed that metal ion dyshomeostasis and miscompartmentalization contribute to AD progression, especially as metal ions (e.g., Cu(II) and Zn(II)) found in Aβ plaques of the diseased brain can bind to Aβ and be linked to aggregation and neurotoxicity. The role of metal ions in AD pathogenesis, however, is uncertain. To accelerate understanding in this area and contribute to therapeutic development, recent efforts to devise suitable chemical reagents that can target metal ions associated with Aβ have been made using rational structure-based design that combines two functions (metal chelation and Aβ interaction) in the same molecule. This paper presents bifunctional compounds developed by two different design strategies (linkage or incorporation) and discusses progress in their applications as chemical tools and/or potential therapeutics. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher Hindawi Publishing Corporation ko
dc.title Recent development of bifunctional small molecules to study metal-amyloid-β species in Alzheimer's disease ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-79251569872 ko
dc.type.rims ART ko
dc.description.scopustc 9 * 2014-11-11 *
dc.identifier.doi 10.4061/2011/623051 ko
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