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DC Field | Value | Language |
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dc.citation.title | MOLECULAR PHARMACEUTICS | - |
dc.contributor.author | Ok, Hae Won | - |
dc.contributor.author | Jin, Seongeon | - |
dc.contributor.author | Park, Gaeun | - |
dc.contributor.author | Jana, Batakrishna | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2024-08-19T10:05:08Z | - |
dc.date.available | 2024-08-19T10:05:08Z | - |
dc.date.created | 2024-08-13 | - |
dc.date.issued | 2024-07 | - |
dc.description.abstract | Recent emphasis on the design of drug delivery systems typically involves the effective transport of a pharmaceutical substance to the disease site with the desired therapeutic efficacy and minimal cytotoxicity. Organelle-targeted peptides have become an integral part of designing an important class of prodrug/prodrug assemblies for new supramolecular therapeutics owing to their favorable biocompatibility, synthetic ease, tunability of their aggregation behavior, and desired functionalization for site-specificity. However, it is still limited due to the low selectivity. We designed a folic acid-functionalized beta-cyclodextrin (FA-CD) as a delivery platform for specific and selective delivery of organelle-targeted (such as microtubule, lysosome, and mitochondria) peptide chemotherapeutics to the folate receptor (FR) overexpressing cancer cell lines. Low toxicity was found for the FA-CD and organelle-targeted peptide inclusion complex in FR-negative normal cells, but superior inhibition of tumor growth with no in vivo toxicity was found for the inclusion complex in the xenograft tumor model. | - |
dc.identifier.bibliographicCitation | MOLECULAR PHARMACEUTICS | - |
dc.identifier.doi | 10.1021/acs.molpharmaceut.4c00400 | - |
dc.identifier.issn | 1543-8384 | - |
dc.identifier.scopusid | 2-s2.0-85199790585 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/83519 | - |
dc.identifier.wosid | 001280420100001 | - |
dc.language | 영어 | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Folic Acid-Functionalized β-Cyclodextrin for Delivery of Organelle-Targeted Peptide Chemotherapeutics in Cancer | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental; Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Research & Experimental Medicine; Pharmacology & Pharmacy | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | peptide amphiphiles | - |
dc.subject.keywordAuthor | self-assembly | - |
dc.subject.keywordAuthor | organelle targeting | - |
dc.subject.keywordAuthor | cancertherapy | - |
dc.subject.keywordAuthor | host-guest interaction | - |
dc.subject.keywordPlus | STAR POLYMER | - |
dc.subject.keywordPlus | PRODRUGS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DESIGN | - |
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