Full metadata record
DC Field | Value | Language |
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dc.citation.number | 2 | - |
dc.citation.startPage | 100029 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 47 | - |
dc.contributor.author | Lee, Hojun | - |
dc.contributor.author | Yoon, Haejin | - |
dc.date.accessioned | 2024-07-26T10:35:18Z | - |
dc.date.available | 2024-07-26T10:35:18Z | - |
dc.date.created | 2024-07-23 | - |
dc.date.issued | 2024-02 | - |
dc.description.abstract | Mitochondria are pivotal for energy regulation and are linked to cancer. Mitochondrial sirtuins, (Sirtuin) SIRT3, SIRT4, and SIRT5, play crucial roles in cancer metabolism. This review explores their impact on cellular processes, with a focus on the NAD+ interplay and the modulation of their enzymatic activities. The varied roles of SIRT3, SIRT4, and SIRT5 in metabolic adaptation and cancer are outlined, emphasizing their tumor suppressor or oncogenic nature. We propose new insights into sirtuin biology, and cancer therapeutics, suggesting an integrated proteomics and metabolomics approach for a comprehensive understanding of mitochondrial sirtuins in cancer. (c) 2024 The Authors. Published by Elsevier Inc. on behalf of Korean Society for Molecular and Cellular Biology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.47, no.2, pp.100029 | - |
dc.identifier.doi | 10.1016/j.mocell.2024.100029 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.scopusid | 2-s2.0-85186353258 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/83319 | - |
dc.identifier.wosid | 001261989800001 | - |
dc.language | 영어 | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Mitochondrial sirtuins: Energy dynamics and cancer metabolism | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Cancer metabolism | - |
dc.subject.keywordAuthor | Mitochondrial sirtuins | - |
dc.subject.keywordAuthor | Mitochondria metabolism | - |
dc.subject.keywordAuthor | NAD plus | - |
dc.subject.keywordAuthor | SIRT3 | - |
dc.subject.keywordPlus | INHIBITS PROSTATE-CANCER | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CALORIE RESTRICTION | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | SIR2 HOMOLOG | - |
dc.subject.keywordPlus | DEACETYLASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
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