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차채녕

Cha, Chaenyung
Integrative Biomaterials Engineering Lab.
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dc.citation.startPage 101055 -
dc.citation.title MATERIALS TODAY BIO -
dc.citation.volume 26 -
dc.contributor.author Lee, Dongjin -
dc.contributor.author Kim, Seok Min -
dc.contributor.author Kim, Dahong -
dc.contributor.author Baek, Seung Yeop -
dc.contributor.author Yeo, Seon Ju -
dc.contributor.author Lee, Jae Jong -
dc.contributor.author Cha, Chaenyung -
dc.contributor.author Park, Su A. -
dc.contributor.author Kim, Tae-Don -
dc.date.accessioned 2024-06-14T14:35:11Z -
dc.date.available 2024-06-14T14:35:11Z -
dc.date.created 2024-06-04 -
dc.date.issued 2024-06 -
dc.description.abstract Recently, interest in cancer immunotherapy has increased over traditional anti-cancer therapies such as chemotherapy or targeted therapy. Natural killer (NK) cells are part of the immune cell family and essential to tumor immunotherapy as they detect and kill cancer cells. However, the disadvantage of NK cells is that cell culture is difficult. In this study, porous microgels have been fabricated using microfluidic channels to effectively culture NK cells. Microgel fabrication using microfluidics can be mass-produced in a short time and can be made in a uniform size. Microgels consist of photo cross-linkable polymers such as methacrylic gelatin (GelMa) and can be regulated via controlled GelMa concentrations. NK92 cell-laden three-dimensional (3D) microgels increase mRNA expression levels, NK92 cell proliferation, cytokine release, and anti-tumor efficacy, compared with twodimensional (2D) cultures. In addition, the study confirms that 3D-cultured NK92 cells enhance anti-tumor effects compared with enhancement by 2D-cultured NK92 cells in the K562 leukemia mouse model. Microgels containing healthy NK cells are designed to completely degrade after 5 days allowing NK cells to be released to achieve cell-to-cell interaction with cancer cells. Overall, this microgel system provides a new cell culture platform for the effective culturing of NK cells and a new strategy for developing immune cell therapy. -
dc.identifier.bibliographicCitation MATERIALS TODAY BIO, v.26, pp.101055 -
dc.identifier.doi 10.1016/j.mtbio.2024.101055 -
dc.identifier.issn 2590-0064 -
dc.identifier.scopusid 2-s2.0-85190775888 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/82993 -
dc.identifier.wosid 001233463000001 -
dc.language 영어 -
dc.publisher ELSEVIER -
dc.title Microfluidics-assisted fabrication of natural killer cell-laden microgel enhances the therapeutic efficacy for tumor immunotherapy -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Engineering, Biomedical; Materials Science, Biomaterials -
dc.relation.journalResearchArea Engineering; Materials Science -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor Microgel mechanics -
dc.subject.keywordAuthor Microgel degradation -
dc.subject.keywordAuthor Cancer immunotherapy -
dc.subject.keywordAuthor Double flow -focusing microfluidics -
dc.subject.keywordAuthor NK92 cell encapsulation -
dc.subject.keywordPlus GELATIN -
dc.subject.keywordPlus HYDROGEL -
dc.subject.keywordPlus CULTURE -
dc.subject.keywordPlus NK -
dc.subject.keywordPlus MICROSPHERES -
dc.subject.keywordPlus ACTIVATION -
dc.subject.keywordPlus MECHANISMS -

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