There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.startPage | 2311071 | - |
dc.citation.title | SMALL | - |
dc.contributor.author | Hu, Cong | - |
dc.contributor.author | Chen, Qi | - |
dc.contributor.author | Wu, Tianyang | - |
dc.contributor.author | Du, Xinxing | - |
dc.contributor.author | Dong, Yanhao | - |
dc.contributor.author | Peng, Zehong | - |
dc.contributor.author | Xue, Wei | - |
dc.contributor.author | Sunkara, Vijaya | - |
dc.contributor.author | Cho, Yoon-Kyoung | - |
dc.contributor.author | Dong, Liang | - |
dc.date.accessioned | 2024-05-09T10:35:08Z | - |
dc.date.available | 2024-05-09T10:35:08Z | - |
dc.date.created | 2024-05-07 | - |
dc.date.issued | 2024-04 | - |
dc.description.abstract | Prostate cancer (PCa) has become a public health concern in elderly men due to an ever-increasing number of estimated cases. Unfortunately, the available treatments are unsatisfactory because of a lack of a durable response, especially in advanced disease states. Extracellular vesicles (EVs) are lipid-bilayer encircled nanoscale vesicles that carry numerous biomolecules (e.g., nucleic acids, proteins, and lipids), mediating the transfer of information. The past decade has witnessed a wide range of EV applications in both diagnostics and therapeutics. First, EV-based non-invasive liquid biopsies provide biomarkers in various clinical scenarios to guide treatment; EVs can facilitate the grading and staging of patients for appropriate treatment selection. Second, EVs play a pivotal role in pathophysiological processes via intercellular communication. Targeting key molecules involved in EV-mediated tumor progression (e.g., proliferation, angiogenesis, metastasis, immune escape, and drug resistance) is a potential approach for curbing PCa. Third, EVs are promising drug carriers. Naive EVs from various sources and engineered EV-based drug delivery systems have paved the way for the development of new treatment modalities. This review discusses the recent advancements in the application of EV therapies and highlights EV-based functional materials as novel interventions for PCa. This review summarizes the pivotal role of extracellular vesicles (EVs) in the treatment of prostate cancer (PCa) comprehensively, including but not limited to promising marker and robust modulator to guide treatment tailoring for PCa, potential target for therapeutic modalities, and promising therapeutic vehicle. It elaborates the opportunities and challenges of EVs in PCa treatment, bringing new insights for researchers. image | - |
dc.identifier.bibliographicCitation | SMALL, pp.2311071 | - |
dc.identifier.doi | 10.1002/smll.202311071 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.scopusid | 2-s2.0-85190656826 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/82340 | - |
dc.identifier.wosid | 001205120900001 | - |
dc.language | 영어 | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | The Role of Extracellular Vesicles in the Treatment of Prostate Cancer | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter | - |
dc.relation.journalResearchArea | Chemistry; Science & Technology - Other Topics; Materials Science; Physics | - |
dc.type.docType | Review; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | functional materials | - |
dc.subject.keywordAuthor | nanomolecule | - |
dc.subject.keywordAuthor | prostate cancer | - |
dc.subject.keywordAuthor | therapeutic targets | - |
dc.subject.keywordAuthor | extracellular vesicles | - |
dc.subject.keywordAuthor | treatment | - |
dc.subject.keywordPlus | EXPRESSION ASSAY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NICHE FORMATION | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TUMOR-IMMUNE MICROENVIRONMENT | - |
dc.subject.keywordPlus | LIQUID BIOPSY | - |
dc.subject.keywordPlus | ENGINEERED EXOSOMES | - |
dc.subject.keywordPlus | ANTITUMOR IMMUNITY | - |
dc.subject.keywordPlus | ANDROGEN RECEPTOR | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.