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Kang, Hyun-Wook
3D Biofabrication Lab.
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DC Field Value Language
dc.citation.number 2 -
dc.citation.startPage 025020 -
dc.citation.title BIOFABRICATION -
dc.citation.volume 16 - Kim, Min Kyeong - Park, Jubin - Tak, Sungho - Paek, Kyurim - Bang, Geul - Woo, Sang-Mi - Ravichandran, Naresh Kumar - Hong, Won Gi - Kang, Hyun-Wook - Kim, Hyang - Bae, Ji Yong - Kim, Jeong Ah - 2024-04-03T14:35:09Z - 2024-04-03T14:35:09Z - 2024-04-03 - 2024-04 -
dc.description.abstract Hydrogels are widely used as scaffold materials for constructing in vitro three-dimensional microphysiological systems. However, their high sensitivity to various external cues hinders the development of hydrogel-laden, microscale, and high-throughput chips. Here, we have developed a long-term storable gel-laden chip composite built in a multi-well plate, which enables in situ cell encapsulation and facilitates high-throughput analysis. Through optimized chemical crosslinking and freeze-drying method (C/FD), we have achieved a high-quality of gel-laden chip composite with excellent transparency, uniform porosity, and appropriate swelling and mechanical characteristics. Besides collagen, decellularized extracellular matrix with tissue-specific biochemical compound has been applied as chip composite. As a ready-to-use platform, in situ cell encapsulation within the gel has been achieved through capillary force generated during gel reswelling. The liver-mimetic chip composite, comprising HepG2 cells or primary hepatocytes, has demonstrated favorable hepatic functionality and high sensitivity in drug testing. The developed fabrication process with improved stability of gels and storability allows chip composites to be stored at a wide range of temperatures for up to 28 d without any deformation, demonstrating off-the-shelf products. Consequently, this provides an exceptionally simple and long-term storable platform that can be utilized for an efficient tissue-specific modeling and various biomedical applications. -
dc.identifier.bibliographicCitation BIOFABRICATION, v.16, no.2, pp.025020 -
dc.identifier.doi 10.1088/1758-5090/ad28ef -
dc.identifier.issn 1758-5082 -
dc.identifier.scopusid 2-s2.0-85185861012 -
dc.identifier.uri -
dc.identifier.wosid 001183314400001 -
dc.language 영어 -
dc.publisher IOP Publishing -
dc.title A long-term storable gel-laden chip composite built in a multi-well plate enabling in situ cell encapsulation for high-throughput liver model -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Engineering, Biomedical;Materials Science, Biomaterials -
dc.relation.journalResearchArea Engineering;Materials Science -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor freeze-dried hydrogel -
dc.subject.keywordAuthor decellularized extracellular matrix -
dc.subject.keywordAuthor high-throughput analysis -
dc.subject.keywordAuthor liver model -
dc.subject.keywordAuthor drug assay -
dc.subject.keywordPlus ON-A-CHIP -
dc.subject.keywordPlus HEPATOCYTE CULTURE -
dc.subject.keywordPlus SCAFFOLDS -
dc.subject.keywordPlus COLLAGEN -
dc.subject.keywordPlus TEMPERATURE -
dc.subject.keywordPlus FABRICATION -


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