Full metadata record
DC Field | Value | Language |
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dc.citation.startPage | 0008 | - |
dc.citation.title | BIOMATERIALS RESEARCH | - |
dc.citation.volume | 28 | - |
dc.contributor.author | Seo, Hee Seung | - |
dc.contributor.author | Han, Jun-Hyeok | - |
dc.contributor.author | Lim, Jaesung | - |
dc.contributor.author | Bae, Ga-Hyun | - |
dc.contributor.author | Byun, Min Ji | - |
dc.contributor.author | Wang, Chi-Pin James | - |
dc.contributor.author | Han, Jieun | - |
dc.contributor.author | Park, Juwon | - |
dc.contributor.author | Park, Hee Ho | - |
dc.contributor.author | Shin, Mikyung | - |
dc.contributor.author | Park, Tae-Eun | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Kim, Se-Na | - |
dc.contributor.author | Park, Wooram | - |
dc.contributor.author | Park, Chun Gwon | - |
dc.date.accessioned | 2024-03-27T16:05:09Z | - |
dc.date.available | 2024-03-27T16:05:09Z | - |
dc.date.created | 2024-03-27 | - |
dc.date.issued | 2024-03 | - |
dc.description.abstract | Background: Cancer recurrence and metastasis are major contributors to treatment failure following tumor resection surgery. We developed a novel implantable drug delivery system utilizing glycol chitosan to address these issues. Glycol chitosan is a natural adjuvant, inducing dendritic cell activation to promote T helper 1 cell immune responses, macrophage activation, and cytokine production. Effective antigen production by dendritic cells initiates T-cell-mediated immune responses, aiding tumor growth control. Methods: In this study, we fabricated multifunctional methacrylated glycol chitosan (MGC) hydrogels with extended release of DNA/doxorubicin (DOX) complex for cancer immunotherapy. We constructed the resection model of breast cancer to verify the anticancer effects of MGC hydrogel with DNA/DOX complex. Results: This study demonstrated the potential of MGC hydrogel with extended release of DNA/DOX complex for local and efficient cancer therapy. The MGC hydrogel was implanted directly into the surgical site after tumor resection, activating tumor-related immune cells both locally and over a prolonged period of time through immune-reactive molecules. Conclusions: The MGC hydrogel effectively suppressed tumor recurrence and metastasis while enhancing immunotherapeutic efficacy and minimizing side effects. This biomaterial-based drug delivery system, combined with cancer immunotherapy, can substantial improve treatment outcomes and patient prognosis. | - |
dc.identifier.bibliographicCitation | BIOMATERIALS RESEARCH, v.28, pp.0008 | - |
dc.identifier.issn | 1226-4601 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/81872 | - |
dc.language | 영어 | - |
dc.publisher | The Korean Society for Biomaterials | BioMed Central | - |
dc.title | Enhanced Postsurgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | kci | - |
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