Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 202 | - |
dc.citation.startPage | 185 | - |
dc.citation.title | BIOACTIVE MATERIALS | - |
dc.citation.volume | 36 | - |
dc.contributor.author | Byun, Hayeon | - |
dc.contributor.author | Han, Yujin | - |
dc.contributor.author | Kim, Eunhyung | - |
dc.contributor.author | Jun, Indong | - |
dc.contributor.author | Lee, Jinkyu | - |
dc.contributor.author | Jeong, Hyewoo | - |
dc.contributor.author | Huh, Seung Jae | - |
dc.contributor.author | Joo, Jinmyoung | - |
dc.contributor.author | Shin, Su Ryon | - |
dc.contributor.author | Shin, Heungsoo | - |
dc.date.accessioned | 2024-03-25T14:05:11Z | - |
dc.date.available | 2024-03-25T14:05:11Z | - |
dc.date.created | 2024-03-25 | - |
dc.date.issued | 2024-06 | - |
dc.description.abstract | Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose a multi-functional composite hydrogel engineered to overcome such conditions through recruitment and activation of macrophages with adapted degradation of the hydrogel. The composite hydrogel (G-TSrP) is created by combining gelatin methacryloyl (GelMA) and nanoparticles (TSrP) composed of tannic acid (TA) and Sr2+. These nanoparticles are prepared using a one-step mineralization process assisted by metal-phenolic network formation. G-TSrP exhibits the ability to eliminate reactive oxygen species and direct polarization of macrophages toward M2 phenotype. It has been observed that the liberation of TA and Sr2+from G-TSrP actively facilitate the recruitment and up-regulation of the expression of extracellular matrix remodeling genes of macrophages, and thereby, coordinate in vivo adapted degradation of the G-TSrP. Most significantly, G-TSrP accelerates angiogenesis despite the TA’s inhibitory properties, which are counteracted by the released Sr2+. Moreover, G-TSrP enhances wound closure under inflammation and promotes normal tissue formation with strong vessel growth. Genetic analysis confirms macrophage-mediated wound healing by the composite hydrogel. Collectively, these findings pave the way for the development of biomaterials that promote wound healing by creating regenerative environment. | - |
dc.identifier.bibliographicCitation | BIOACTIVE MATERIALS, v.36, pp.185 - 202 | - |
dc.identifier.doi | 10.1016/j.bioactmat.2024.02.029 | - |
dc.identifier.issn | 2452-199X | - |
dc.identifier.scopusid | 2-s2.0-85186646721 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/81798 | - |
dc.identifier.wosid | 001189065700001 | - |
dc.language | 영어 | - |
dc.publisher | KEAI PUBLISHING LTD | - |
dc.title | Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical;Materials Science, Biomaterials | - |
dc.relation.journalResearchArea | Engineering;Materials Science | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Composite hydrogels | - |
dc.subject.keywordAuthor | Immunomodulation | - |
dc.subject.keywordAuthor | Multi-functional nanoparticles | - |
dc.subject.keywordAuthor | Neovascularization | - |
dc.subject.keywordAuthor | Wound healing | - |
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