Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 3630 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 3618 | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 51 | - |
dc.contributor.author | Gao, Ye | - |
dc.contributor.author | Bang, Ina | - |
dc.contributor.author | Seif, Yara | - |
dc.contributor.author | Kim, Donghyuk | - |
dc.contributor.author | Palsson, Bernhard O. | - |
dc.date.accessioned | 2024-02-15T17:35:13Z | - |
dc.date.available | 2024-02-15T17:35:13Z | - |
dc.date.created | 2024-02-15 | - |
dc.date.issued | 2023-05 | - |
dc.description.abstract | While global transcription factors (TFs) have been studied extensively in Escherichia coli model strains, conservation and diversity in TF regulation between strains is still unknown. Here we use a combination of ChIP-exo-to define ferric uptake regulator (Fur) binding sites-and differential gene expression-to define the Fur regulon in nine E. coli strains. We then define a pan-regulon consisting of 469 target genes that includes all Fur target genes in all nine strains. The pan-regulon is then divided into the core regulon (target genes found in all the strains, n = 36), the accessory regulon (target found in two to eight strains, n = 158) and the unique regulon (target genes found in one strain, n = 275). Thus, there is a small set of Fur regulated genes common to all nine strains, but a large number of regulatory targets unique to a particular strain. Many of the unique regulatory targets are genes unique to that strain. This first-established pan-regulon reveals a common core of conserved regulatory targets and significant diversity in transcriptional regulation amongst E. coli strains, reflecting diverse niche specification and strain history. | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.51, no.8, pp.3618 - 3630 | - |
dc.identifier.doi | 10.1093/nar/gkad253 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.scopusid | 2-s2.0-85159551257 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/81405 | - |
dc.identifier.wosid | 000963506200001 | - |
dc.language | 영어 | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | The Escherichia coli Fur pan-regulon has few conserved but many unique regulatory targets | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | UNCHARACTERIZED TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | GENOME-SCALE | - |
dc.subject.keywordPlus | IRON | - |
dc.subject.keywordPlus | RECONSTRUCTION | - |
dc.subject.keywordPlus | DATABASE | - |
dc.subject.keywordPlus | STRAIN | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | ROLES | - |
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