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dc.citation.endPage 409 -
dc.citation.number 6 -
dc.citation.startPage 395 -
dc.citation.volume 32 - Won, Woojin - Kim, Daeun - Shin, Eunjin - Lee, C. Justin - 2024-02-15T17:05:09Z - 2024-02-15T17:05:09Z - 2024-02-15 - 2023-12 -
dc.description.abstract The μ-opioid receptor (MOR) is a class of opioid receptors characterized by a high affinity for β-endorphin and morphine. MOR is a G protein-coupled receptor (GPCR) that plays a role in reward and analgesic effects. While expression of MOR has been well established in neurons and microglia, astrocytic MOR expression has been less clear. Recently, we have reported that MOR is expressed in hippocampal astrocytes, and its activation has a critical role in the establishment of conditioned place preference. Despite this critical role, the expression and function of astrocytic MOR from other brain regions are still unknown. Here, we report that MOR is significantly expressed in astrocytes and GABAergic neurons from various brain regions including the hippocampus, nucleus accumbens, periaqueductal gray, amygdala, and arcuate nucleus. Using the MOR-mCherry reporter mice and Imaris analysis, we demonstrate that astrocytic MOR expression exceeded 60% in all tested regions. Also, we observed similar MOR expression of GABAergic neurons as shown in the previous distribution studies and it is noteworthy that MOR expression is particularly in parvalbumin (PV)-positive neurons. Furthermore, consistent with the normal MOR function observed in the MOR-mCherry mouse, our study also demonstrates intact MOR functionality in astrocytes through iGluSnFr-mediated glutamate imaging. Finally, we show the sex-difference in the expression pattern of MOR in PV-positive neurons, but not in the GABAergic neurons and astrocytes. Taken together, our findings highlight a substantial astrocytic MOR presence across various brain regions. © Experimental Neurobiology 2023. -
dc.identifier.bibliographicCitation EXPERIMENTAL NEUROBIOLOGY, v.32, no.6, pp.395 - 409 -
dc.identifier.doi 10.5607/EN23039 -
dc.identifier.issn 1226-2560 -
dc.identifier.scopusid 2-s2.0-85183549220 -
dc.identifier.uri -
dc.identifier.wosid 001167715100003 -
dc.language 영어 -
dc.publisher 한국뇌신경과학회 -
dc.title Mapping Astrocytic and Neuronal μ-opioid Receptor Expression in Various Brain Regions Using MOR-mCherry Reporter Mouse -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Medicine, Research & Experimental;Neurosciences -
dc.relation.journalResearchArea Research & Experimental Medicine;Neurosciences & Neurology -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.description.journalRegisteredClass kci -
dc.subject.keywordAuthor Astrocytes -
dc.subject.keywordAuthor Mapping -
dc.subject.keywordAuthor Mu-opioid receptor -
dc.subject.keywordAuthor Sex-difference -
dc.subject.keywordPlus BASOLATERAL AMYGDALA -
dc.subject.keywordPlus GLUTAMATE RELEASE -
dc.subject.keywordPlus SEX-DIFFERENCES -


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