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DC Field | Value | Language |
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dc.citation.endPage | 1366 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1351 | - |
dc.citation.title | LAB ON A CHIP | - |
dc.citation.volume | 24 | - |
dc.contributor.author | Yoon, Heejeong | - |
dc.contributor.author | Sabaté del Río, Jonathan | - |
dc.contributor.author | Cho, Seung Woo | - |
dc.contributor.author | Park, Tae-Eun | - |
dc.date.accessioned | 2024-02-14T13:35:10Z | - |
dc.date.available | 2024-02-14T13:35:10Z | - |
dc.date.created | 2024-02-13 | - |
dc.date.issued | 2024-03 | - |
dc.description.abstract | Tumor metastasis involves complex processes that traditional 2D cultures and animal models struggle to fully replicate. Metastatic tumors undergo a multitude of transformations, including genetic diversification, adaptation to diverse microenvironments, and modified drug responses, contributing significantly to cancer-related mortality. Micro-physiological systems (MPS) technology emerges as a promising approach to emulate the metastatic process by integrating critical biochemical, biomechanical, and geometrical cues at a microscale. These systems are particularly advantageous simulating metastasis organotropism, the phenomenon where tumors exhibit a preference for metastasizing to particular organs. Organotropism is influenced by various factors, such as tumor cell characteristics, unique organ microenvironments, and organ-specific vascular conditions, all of which can be effectively examined using MPS. This review surveys the recent developments in MPS research from the past five years, with a specific focus on their applications in replicating tumor metastasis and organotropism. Furthermore, we discuss the current limitations in MPS-based studies of organotropism and propose strategies for more accurately replicating and analyzing the intricate aspects of organ-specific metastasis, which is pivotal in the development of targeted therapeutic approaches against metastatic cancers. © 2024 The Royal Society of Chemistry. | - |
dc.identifier.bibliographicCitation | LAB ON A CHIP, v.24, no.5, pp.1351 - 1366 | - |
dc.identifier.doi | 10.1039/d3lc01033c | - |
dc.identifier.issn | 1473-0197 | - |
dc.identifier.scopusid | 2-s2.0-85183939497 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/81355 | - |
dc.identifier.wosid | 001155343600001 | - |
dc.language | 영어 | - |
dc.publisher | Royal Society of Chemistry | - |
dc.title | Recent advances in micro-physiological systems for investigating tumor metastasis and organotropism | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods;Chemistry, Multidisciplinary;Chemistry, Analytical;Nanoscience & Nanotechnology;Instruments & Instrumentation | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology;Chemistry;Science & Technology - Other Topics;Instruments & Instrumentation | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | MICROFLUIDIC CHIP | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | LIVER | - |
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