dc.citation.conferencePlace |
US |
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dc.citation.startPage |
525 |
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dc.citation.title |
42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence |
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dc.contributor.author |
Park S. |
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dc.contributor.author |
Choi B. |
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dc.contributor.author |
Bae Y. |
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dc.contributor.author |
Kang S. |
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dc.date.accessioned |
2024-02-01T00:37:24Z |
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dc.date.available |
2024-02-01T00:37:24Z |
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dc.date.created |
2020-02-20 |
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dc.date.issued |
2019-04-03 |
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dc.description.abstract |
Statement of Purpose: Recombinant immunotoxins (RITs) have been extensively utilized in the field of targeted cancer therapy. RITs are composed of toxins derived from natural bacterial strains and antibodies for target specific toxin delivery, causing fatal effects on the cancer cells. However, low intracellular penetration and endosomal escape efficiency of toxin part has limited the application of the RITs. The diphtheria toxins are produced by bacteria, Corynebacterium diphtheriae, and belong to AB toxin families which consist of catalytic (A) domain, binding (B) domain, and translocation (T) domain. Once the B domain binds to the specific target receptors, it facilitates the receptor-mediated endocytosis. At the endosome, T domain delivers A domain to cytosol, resulting in cell apoptosis (Figure 1). |
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dc.identifier.bibliographicCitation |
42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, pp.525 |
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dc.identifier.issn |
1526-7547 |
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dc.identifier.scopusid |
2-s2.0-85065418807 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/80053 |
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dc.language |
영어 |
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dc.publisher |
Society for Biomaterials |
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dc.title |
Target-switchable modular bacterial toxin delivery system |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2019-04-03 |
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