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Kim, So Youn
Laboratory for Soft Materials Nanophysics
Research Interests
  • Colloids, particle dispersions, polymer nanocomposite, block copolymers

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Decoupled control of stiffness and permeability with a cell-encapsulating poly(ethylene glycol) dimethacrylate hydrogel

Cited 33 times inthomson ciCited 32 times inthomson ci
Title
Decoupled control of stiffness and permeability with a cell-encapsulating poly(ethylene glycol) dimethacrylate hydrogel
Author
Cha, ChaenyungKim, So YounCao, LanKong, Hyunjoon
Keywords
Cell encapsulation; Elastic modulus; Hydrogel; Methacrylic alginate; Poly(ethylene glycol); Swelling ratio
Issue Date
2010-06
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v.31, no.18, pp.4864 - 4871
Abstract
Hydrogels are increasingly used as a cell encapsulation and transplantation device. The successful use of a hydrogel greatly relies on an ability to control hydrogel stiffness which affects structural integrity and regulates cellular phenotypes. However, conventional strategies to increase the gel stiffness lead to decrease in the gel permeability and subsequently deteriorate the viability of cells encapsulated in a gel matrix. This study presents a strategy to decouple the inversed dependency of permeability on the stiffness of a hydrogel by chemically cross-linking methacrylic alginate with poly(ethylene glycol) dimethacrylate (PEGDA). As expected, gel stiffness represented by elastic modulus was tuned over one order of magnitude with the concentration of methacrylic alginate and the degree of substitution of methacrylic groups. In contrast, swelling ratio of the hydrogel indicative of gel permeability was minimally changed because of multiple hydrophilic groups of alginate, similar to function of proteoglycans in a natural extracellular matrix. Furthermore, viability of neural cells encapsulated in a hydrogel of PEGDA and methacrylic alginate rather increased with hydrogel stiffness. Overall, the results of this study demonstrate an advanced biomaterial design paradigm which allows one to culture cells in a 3D matrix of varying rigidity. This study will therefore greatly expedite the use of a hydrogel system in both fundamental studies and clinical settings of cell therapies.
URI
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DOI
10.1016/j.biomaterials.2010.02.059
ISSN
0142-9612
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MSE_Journal Papers
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