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Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery


Integrative deign of a poly(ethylene glycol)-poly(propylene glycol)-alginate hydrogel to control three dimensional biomineralization

DC Field Value Language Cha, Chaenyung ko Kim, Eun-Seok ko Kim, Il Won ko Kong, Hyunjoon ko 2014-10-29T00:20:26Z - 2014-10-27 ko 2011-04 -
dc.identifier.citation BIOMATERIALS, v.32, no.11, pp.2695 - 2703 ko
dc.identifier.issn 0142-9612 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract A mineralized polymeric matrix has been extensively studied to understand biomineralization processes and to further regulate phenotypic functions of various cells involved in osteogenesis and physiological homeostasis. It has been often proposed that several matrix variables including charge density, hydrophobicity, and pore size play vital roles in modulating composition and morphology of minerals formed within a three dimensional (3D) matrix. However, the aspects have not yet been systematically examined because a tool enabling the independent control of the matrix variables is lacking. This study presents an advanced integrative strategy to control morphology and composition of biominerals with matrix properties, by using a hydrogel formulated to independently control charge density, hydrophobicity, and porosity. The hydrogel consists of poly(ethylene glycol) monomethacrylate (PEGmM), poly(propylene glycol) monomethacrylate (PPGmM), and methacrylic alginate (MA), so the charge density and hydrophobicity of the hydrogel can be separately controlled with mass fractions of MA and PPGmM. Also, hydrogels which present only nano-sized pores, termed nanoporous hydrogels, are lyophilized and rehydrated to prepare the hydrogels containing micro-sized pores, termed microporous hydrogels. We find that increasing the mass fractions of MA and PPGmM of the microporous hydrogel promotes the growth of apatite layers because of the increases in the charge density, hydrophobicity and pore size. In contrast, increasing mass fractions of MA and PPGmM of the nanoporous hydrogel enhances the formation of calcium carbonate minerals. The dependency of the mineralization on hydrogel variables is related to the change in supersaturation of mineral ions. Overall, the results of this study will be highly useful to better understand the interplay of matrix variables in biomineralization and to design a wide array of mineralized matrix potentially used in cell therapies and tissue engineering. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher ELSEVIER SCI LTD ko
dc.subject Biomineralization ko
dc.subject Charge density ko
dc.subject Hydrogel ko
dc.subject Hydrophobicity ko
dc.subject Pore size ko
dc.title Integrative deign of a poly(ethylene glycol)-poly(propylene glycol)-alginate hydrogel to control three dimensional biomineralization ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-79951578146 ko
dc.identifier.wosid 000288465800002 ko
dc.type.rims ART ko
dc.description.wostc 17 *
dc.description.scopustc 13 * 2015-05-06 * 2014-10-27 *
dc.identifier.doi 10.1016/j.biomaterials.2010.12.038 ko
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