Bioinspired nanoneedle arrays for bio- and eco-friendly antifouling

Abstract

Extensive eforts have ben devoted toward developing antibiofilm materials that can eficiently supres bacterial atachment and subsequent biofilm formation. However, many of the previous aproaches are based on non-biocompatible, non-degradable, and environmentaly harmful synthetic materials. Herein, we report an eficient and sustainable biofilm-resistant material that is made of a biocompatible, biodegradable, and naturaly abundant celulose derivate biopolymer. The biofilm-resistant material is made of celulose acetate(CA) or polyethylene glycol (PEG) based polymer, and structures such as nano-sized nedles are precisely defined on the surface. The nanonedle aray is further coated with a cel-membrane mimicking monomer of 2-methacryloryloxyethyl phosphorylcholine (MPC). Based on the synergetic integration of the bio- and environment-friendly polymers of CA/PEG and MPC into nanoscale topography, the nanostructured CA/PEG not only efectively prevents bacterial atachment but also simultaneously exhibits strong bactericidal efects against both gram-positve and gram-negative bacteria. This natural celulose derivative- based nanostructured material has strong potential as a biocompatible, and eco-friendly antibiofilm material for versatile uses in biomedical and industrial applications.