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DC Field | Value | Language |
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dc.citation.conferencePlace | KO | - |
dc.citation.conferencePlace | Online | - |
dc.citation.title | The 23rd Annual Meeting of the Korean Society for Brain and Neural Sciences | - |
dc.contributor.author | Lee, Byeong Eun | - |
dc.contributor.author | Kim, Hye Yun | - |
dc.contributor.author | Kim, Hyun-Jin | - |
dc.contributor.author | Jeong, Hyeongsun | - |
dc.contributor.author | Kim, Byung-Gyu | - |
dc.contributor.author | Lee, Ha-Eun | - |
dc.contributor.author | Lee, Jieun | - |
dc.contributor.author | Kim, Han Byeol | - |
dc.contributor.author | Lee, Seung Eun | - |
dc.contributor.author | Yang, Yong Ryoul | - |
dc.contributor.author | Yi, Eugene C. | - |
dc.contributor.author | Hanover, John A. | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Kwon, Taejoon | - |
dc.contributor.author | Kim, Jae-Ick | - |
dc.date.accessioned | 2024-01-31T22:35:51Z | - |
dc.date.available | 2024-01-31T22:35:51Z | - |
dc.date.created | 2020-12-18 | - |
dc.date.issued | 2020-11-17 | - |
dc.description.abstract | Dopamine system in the midbrain is important for volitional movement, action selection, and reward-related learning. Even though dopamine system mediates versatile functions, it contains only a small set of neurons in the midbrain. Moreover, these dopamine neurons are highly susceptible to Parkinson’s disease (PD) and degenerate during disease progression. Here, we reveal that O-GlcNAcylation, an important post-translational modification in cells, is essential for survival and function of dopamine neurons. Modulation of O-GlcNAc level critically regulates dopamine neurons at molecular, synaptic, cellular, and behavioral levels. Notably, up-regulation of O-GlcNAcylation in dopamine neurons alleviates neurodegeneration, synaptic impairments, and motor deficits in an animal model of PD. These findings suggest the importance of O-GlcNAcylation in the dopamine system and may provide new therapeutic approach to protect dopamine neurons against PD pathology. | - |
dc.identifier.bibliographicCitation | The 23rd Annual Meeting of the Korean Society for Brain and Neural Sciences | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/77868 | - |
dc.language | 영어 | - |
dc.publisher | The Korean Society for Brain and Neural Sciences | - |
dc.title | The critical role of O-GlcNAcylation in dopamine neuron function, survival, and degeneration in health and Parkinson’s disease | - |
dc.type | Conference Paper | - |
dc.date.conferenceDate | 2020-11-16 | - |
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