dc.citation.conferencePlace |
KO |
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dc.citation.title |
127th General Meeting of the Korean Chemical Society |
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dc.contributor.author |
Choi, Huyoen |
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dc.contributor.author |
Ryu, Ja-Hyoung |
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dc.date.accessioned |
2024-01-31T22:06:36Z |
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dc.date.available |
2024-01-31T22:06:36Z |
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dc.date.created |
2021-07-09 |
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dc.date.issued |
2021-04-23 |
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dc.description.abstract |
Mitochondria are essential intracellular organelles involved in many cellular processes, especially adenosine triphosphate (ATP) production. Since cancer cells require high ATP levels for proliferation, ATP elimination can be a unique target for cancer growth inhibition. We describe a newly developed mitochondria-targeting nucleopeptide (MNP) that sequesters ATP by self-assembling with ATP inside mitochondria. MNP interacts with ATP strongly through electrostatic and hydrogen bonding interactions. MNP exhibits higher binding affinity for ATP (−637.5 kJ/mol) than for adenosine diphosphate (ADP) (−578.2 kJ/mol). To improve anticancer efficacy, the small-sized MNP/ADP complex formed large assemblies with ATP inside cancer cell mitochondria. ATP sequestration and formation of large assemblies of the MNP/ADP–ATP complex inside mitochondria caused physical stress by large structures and metabolic disorders in cancer cells, leading to apoptosis. This work illustrates a facile approach to developing cancer therapeutics that relies on molecular assemblies. |
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dc.identifier.bibliographicCitation |
127th General Meeting of the Korean Chemical Society |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/77488 |
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dc.identifier.url |
http://new.kcsnet.or.kr/?mid=abstract_view&uid=56726&page=1&qpage=&word=SequesteringATPinsideMitochondriabyNucleopeptideAssemblyInducesCancerCellApoptosis&wordfield=subject&main_number=127 |
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dc.publisher |
Korean Chemical Society |
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dc.title |
Sequestering ATP inside Mitochondria by Nucleopeptide Assembly Induces Cancer Cell Apoptosis |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2021-04-21 |
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