dc.citation.conferencePlace |
KO |
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dc.citation.title |
The 2021 Annual Fall Meeting of Polymer Society of Korea |
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dc.contributor.author |
Kim, Dohyun |
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dc.contributor.author |
Kim, Sangpil |
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dc.contributor.author |
Choi, Huyeon |
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dc.contributor.author |
Park, Gaeun |
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dc.contributor.author |
Ryu, Ja-Hyoung |
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dc.date.accessioned |
2024-01-31T21:10:52Z |
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dc.date.available |
2024-01-31T21:10:52Z |
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dc.date.created |
2021-11-12 |
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dc.date.issued |
2021-10-22 |
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dc.description.abstract |
In a conventional approach for cancer therapy, overcoming off-targeting effect has been a key issue to solve. Here, we hypothesize that enzyme-targeting system can be a novel approach to increase the selectivity toward cancer cells. We describe an amphiphilic tetrapeptide, Pep-AT, which can target cancer cells based on high affinity with cancer-overexpressing carbonic anhydrase IX (CAIX) enzyme. A local concentration of Pep-AT around cancer cells increases due to the far-from-equilibrium of Pep-AT toward CAIX over time, as followed by forming nanofiber structure on plasma membrane. The nanofiber can be internalized into lysosome through CAIX-mediated endocytosis, as thereby disrupting lysosomal membrane integrity. Therefore, Pep-AT can selectively induce cell death for HeLa (CAIX-positive cell line), detouring around NIH/3T3 (CAIX-negative cell line). |
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dc.identifier.bibliographicCitation |
The 2021 Annual Fall Meeting of Polymer Society of Korea |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/76820 |
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dc.identifier.url |
http://www.polymer.or.kr/english2/sub1/PaperDetail.php?pid=36296 |
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dc.publisher |
The polymer society of Korea |
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dc.title |
Overcoming low selectivity with CAIX-targeting Amphiphilic Peptide inducing cell death |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2021-10-20 |
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